Congenital heart disease

This trial asks whether one way of setting a breathing machine is better than another for children born with a hole in the heart who are having surgery to close it. The hole lets extra blood flow to the lungs, which can make them stiff and harder to inflate. During surgery, a mac…

Autistic children drown at 160 times the rate of their peers, yet standard swim lessons often fail them. This study tests a new approach that adapts instruction based on a child's sensory profile—whether they seek, avoid, or have mixed reactions to sensory input. Researchers will…

This trial investigates whether cardiac resynchronization therapy (CRT) — a special type of pacing — can improve how far people can walk in six minutes. It includes adults with congenital heart disease where the right ventricle pumps blood to the body (systemic right ventricle). …

This trial tests whether a personalized physical activity plan can help children aged 5–18 with congenital heart disease increase their exercise capacity and daily activity levels. The plan is designed with input from parents, teachers, and a pediatric cardiologist to address saf…

This study tests whether a therapeutic education program helps teenagers and young adults with congenital heart disease transition from pediatric to adult medical care. Participants aged 13 to 25 will either receive the education program or standard follow-up. Researchers will me…

This study followed 500 people who received the Amplatzer PFO Occluder, a device that closes a small hole in the heart called PFO. Researchers tracked serious complications within 30 days and longer-term issues like stroke or blood clots over 3 years. The goal was to confirm the …

This study looked at the safety and how the body processes two doses of nirsevimab, a medicine to prevent RSV, given 5 to 6 months apart. It included 33 Japanese infants up to 12 months old with heart or lung disease, weak immune systems, Down syndrome, or who were born early. Re…

This study looked at whether giving thiamine (vitamin B1) for 28 days after a heart defect repair procedure helps children's hearts recover. The trial included 86 children aged 6 months to 18 years with certain heart defects. Researchers measured heart structure and function usin…

This study tested a special device (GORE® CARDIOFORM ASD Occluder) to close a common type of hole in the heart called an atrial septal defect (ASD). The goal was to see if the device could safely and effectively seal the hole using a tube inserted through a blood vessel, avoiding…

This study tested a new delivery system for implanting devices that close holes in the heart, such as PFO and ASD. It involved 254 patients and measured how well the system worked and how safe it was. The goal was to confirm that the system performs well in real-world use.

This study tested whether giving acetaminophen (a common pain and fever medicine) to extremely preterm babies within the first 12 hours after birth can help close a blood vessel in the heart that normally closes on its own. The trial involved 804 babies born between 23 and 28 wee…

This study tested a new device called Absnow that can close a common type of hole in the heart (atrial septal defect) and then dissolve over time. 165 patients, including children as young as 3, received the device. The goal was to see if it safely closes the hole without major p…

This study tested whether injecting a child's own heart stem cells during a planned surgery could help their heart work better. It involved 25 children with hypoplastic left heart syndrome, a condition where the left side of the heart is underdeveloped. The main goals were to see…

This study tested whether giving the steroid methylprednisolone before and during heart surgery could reduce dangerous inflammation in infants under one year old. Over 1,200 babies were randomly assigned to receive either the steroid or a placebo (salt water). Researchers tracked…

This study tested whether paracetamol works as well as ibuprofen for closing a common heart duct problem in premature infants. 133 babies born at or before 30 weeks were randomly given one of the two drugs. The goal was to see which drug closes the duct more effectively and safel…

This study looked at the SAPIEN XT heart valve, which is placed through a thin tube (catheter) to fix a failed valve in the heart's right ventricle. Researchers wanted to confirm it is safe and works well. They enrolled 57 people with a narrowed or leaky heart valve conduit. The …

This study tested whether giving vitamin E (alpha-tocopherol) during heart surgery could reduce heart muscle damage in children with Tetralogy of Fallot, a birth defect. 58 children aged 1-10 years received either vitamin E or a placebo at the start of surgery. The main goal was …

This study tested a new valve called the Pulsta® Transcatheter Pulmonary Valve in 15 people with congenital heart disease and a faulty pulmonary valve. The valve is implanted through a catheter, avoiding open-heart surgery. Researchers checked if the valve improved blood flow and…

This study is testing whether an artificial intelligence system can accurately identify congenital heart disease in children by analyzing heart sounds. It will involve thousands of children, with and without heart conditions, to compare the AI's performance against traditional me…

This trial tests whether a magnetic sensor placed on the skin can accurately measure blood pressure in the jugular vein and radial artery, compared to standard invasive methods using catheters. The study involves 10 adults with complex congenital heart disease or chronic right he…

This completed study looked at 313 children to see if blood tests and advanced heart scans could help detect congenital heart disease earlier and predict which children might need surgery. Researchers compared children with heart defects to healthy controls using blood biomarkers…

This large study in China compared how well primary care doctors detect congenital heart disease in children using a regular stethoscope versus an AI-assisted electronic stethoscope. Nearly 20,000 children aged 0-18 from schools and kindergartens were screened. The goal was to se…

This completed trial compared how well primary care doctors detect congenital heart disease in children using either their own listening skills or an AI-assisted stethoscope. The AI analyzes heart sounds in real time and gives an immediate result. The study enrolled 212 children …

This study tested a new contrast agent called NH002 in 36 adults with heart disease. The agent is used during heart ultrasound to make the heart's chambers and borders clearer. The main goal was to check safety by monitoring vital signs, heart activity, and allergic reactions aft…

Very premature infants born before 28 weeks often have a blood vessel near the heart, called the patent ductus arteriosus, that stays open when it should close. A large opening can strain the heart and may affect brain development. In this trial, researchers use an early echocard…

This study tested whether giving paracetamol (a common painkiller) early can prevent a heart opening called PDA from staying open in extremely premature infants (born before 30 weeks or under 1250 grams). 40 babies were randomly given either paracetamol or the standard drug indom…

Researchers are testing whether a hybrid cardiac rehabilitation programme can help adults recover after heart surgery. Participants start with two weeks of supervised exercise at the hospital, then continue training at home for six weeks using heart-rate monitors, a cloud care pl…

This trial tests HEARTPrep, a virtual counseling program designed to support mothers who are expecting a baby with congenital heart disease. The program aims to reduce depression, anxiety, and social isolation during pregnancy. Researchers will enroll 30 mothers and their partner…

This trial compares two simple educational tools—an animated video and a brochure—against routine care to see which best lowers anxiety and fear in children aged 7 to 10 who need an echocardiogram. All participants have a congenital heart condition and are scheduled for a follow-…

This study looks at whether using a video laryngoscope (a camera-equipped scope) helps doctors place a breathing tube through the nose more successfully on the first try compared to a standard direct laryngoscope in infants under 1 year with congenital heart disease. About 180 in…

This trial investigates whether using a bedside ultrasound machine can help doctors and nurses place feeding tubes more accurately in children aged 0 to 6 years who have congenital heart disease. The study will compare the accuracy of tube placement when ultrasound is used versus…

This study tested whether a nasal spray containing vasopressin, a natural hormone, can improve social functioning in children with autism. 157 children aged 6 to 17 took part. Researchers measured changes in social responsiveness and overall symptoms over 8 weeks.

This study tested whether using virtual reality glasses during physical therapy can reduce pain, improve blood oxygen levels, and help children walk farther after open heart surgery. Forty children aged 6 to 12 took part. One group used VR glasses during their cardiac rehab exerc…

This study looked at whether different types of exercise training can help adults with congenital heart disease exercise more easily. 47 participants were split into three groups: interval training, moderate continuous training, or usual care (no training). The main goal was to s…

This completed Phase 2 trial tested whether blood thinners (rivaroxaban) or antiplatelet drugs (aspirin, clopidogrel) work better than standard migraine medication (metoprolol) for people with both migraine and a small heart hole called PFO. 1,000 participants took one of the fou…

This study tested if online speech therapy could help babies with congenital heart disease who are fed only through a tube. Twenty babies aged 0 to 12 months received 10 days of online therapy from a speech therapist. The goal was to see if they could drink more milk by mouth and…

This study tested whether adapted judo training plus nutritional counseling could improve physical fitness, body composition, and stability in children and adolescents with autism spectrum disorder (ASD). One hundred participants aged 7–14, with and without ASD, took part in 10 m…

This study looked at 60 children aged 3-8 years who needed a procedure to close a hole in their heart. Researchers compared general anesthesia to a lighter sedation combined with numbing medicine at the catheter site. They measured heart rate and blood pressure to see which appro…

This study tested a special nerve block (serratus anterior plane block) to see if it could reduce pain and the need for strong painkillers like fentanyl in children after heart surgery. 48 children having heart surgery through a chest incision took part. The goal was to find a sa…

This study looked at 102 children who had surgery for a heart problem present at birth. After surgery, they were placed on their stomachs with their heads raised at different angles (10°, 30°, or 45°) to see which angle best helped their heart and lungs recover. The goal was to f…

This study tested if combining cartoon-watching with nurse interaction could ease pain in children after heart surgery. 70 kids aged 3-7 took part; half got standard pain care, and the other half also watched cartoons with a nurse. The goal was to see if this fun, non-drug approa…

This study tested a program called PRISM to help adults with congenital heart disease build resilience and manage stress. 78 adults with moderate or complex heart conditions took part. Researchers checked if the program was feasible and if it improved resilience scores compared t…

This study tested a virtual, group-based parenting program called 'Tuning in to Kids' for parents of children aged 3 to 6 with congenital heart disease. The goal was to see if the program was easy to use and helpful for parents. Thirty-nine parents took part in online surveys, we…

This study tested whether online group exercise training could help children aged 6-18 with pacemakers become more active and improve their strength and quality of life. 36 children were split into two groups: one did online exercise sessions three times a week for eight weeks, w…

Children with congenital heart disease often need a breathing machine after surgery, and the pressure it creates can affect blood flow to the brain. This study compares conventional ventilation with NAVA, a mode that works with the child's own breathing signals, in 30 children re…

This study looked for genetic causes of congenital heart disease (heart problems present at birth) in families from Uganda and Nigeria. Over 1,200 people took part, including affected children and their parents. Researchers used advanced DNA testing to find gene changes linked to…

This study tested a new parent questionnaire called ORALQUEST to assess feeding and eating disorders in children aged 9 months to 6 years. Researchers included 338 children with chronic conditions like heart defects or autism, as well as those with picky eating. The goal was to s…

This study is testing whether an artificial intelligence model can predict how the aorta might dilate (widen) in people with bicuspid aortic valve—a common heart valve condition that raises the risk of aortic aneurysm. Researchers will analyze CT scans from 1,000 patients who had…

This study looks at whether children born with heart defects who need surgery might also have delays in speech and thinking. Researchers will check the children's cognitive and language skills before their operation and again one and two years after. The goal is to see if speech …

This study looks at how leg muscle size and strength affect circulation in people born with a single-chamber heart, a condition where the heart can't pump blood to the lungs on its own. Researchers will measure muscle mass, oxygen use, and quality of life in 40 adults aged 16-50 …

This study looks at whether the 'circle method' — a way to measure the aortic valve — can help doctors choose the right size replacement valve for people with bicuspid aortic valves who are getting a TAVI procedure. Researchers will review past cases to see if patients whose valv…

This study tests a small, wearable ECG patch that uses artificial intelligence to monitor heart rhythms in patients recovering from cardiac surgery. Participants wear the patch for up to a week after leaving the intensive care unit. The goal is to see if the device can reliably t…

This trial tests two methods for taking children off mechanical ventilation after heart surgery: pressure support ventilation (PSV) and automatic tube compensation (ATC). The goal is to see which approach reduces the work of breathing and improves lung function. The study include…

This study looks at how blood flow to the fetal brain is affected in babies with congenital heart disease and whether it relates to their development after birth. Pregnant women with a fetus known or suspected to have a heart defect will have a fetal echocardiogram, then breathe …

This study tested whether a newer type of MRI called 4D flow can more accurately measure leakage in the pulmonary valve and heart chamber size in people born with tetralogy of Fallot who had corrective surgery. Researchers compared 4D flow MRI with standard 2D MRI in 21 patients …

This study tested whether giving personalized nutrition training to mothers of children with congenital heart disease helps their kids grow better after heart surgery. The training covered feeding from birth to age 3, including breastfeeding and starting solid foods. Researchers …

This study tested a mobile health program called Heart2Heart for teens aged 12-18 with congenital heart disease. The goal was to see if teens liked the program and found it easy to use. Seventeen teens completed surveys, used the app, and gave feedback in interviews.

This study follows 150 people with bicuspid aortic stenosis—a narrowed heart valve present from birth—who receive a transcatheter aortic valve replacement (TAVI) using the Evolut Pro or Evolut R XL device. Researchers will measure how well the valve works over time, including blo…

This study looked at 40 children with congenital heart disease who had heart surgery. During surgery, doctors used a special filtering technique called SBUF-SMUF to remove inflammatory substances from the blood. The goal was to see how this affected inflammation and recovery. The…

This study tested whether using a pulse oximeter (a small sensor on the foot or hand) to measure oxygen levels in all seemingly healthy newborns can help find hidden, life-threatening heart defects early. Over 44,000 babies took part. The goal was to see if this screening reduces…

This study looked at new ways to test blood clotting in 200 children with congenital heart disease undergoing surgery. The goal was to see if newer technologies like TEG, ROTEM, and T2MR could help doctors manage bleeding more precisely and reduce the need for blood transfusions.…

This study collected information from over 15,000 people hospitalized with cardiomyopathy, a heart muscle disease. Researchers looked at how much these hospital stays cost and what the money was spent on. The goal was to understand the real-world financial impact and help manage …

This study screened 233 children aged 6 to 66 months with congenital heart disease for neurodevelopmental disorders like delays in communication, movement, and problem-solving. Researchers used a parent questionnaire to identify children at risk. The goal is to better understand …

This study looked at 11 people with a repaired heart condition called tetralogy of Fallot who needed a new pulmonary valve. Researchers used MRI scans to measure heart muscle stiffness (fibrosis) and how well the heart pumped during rest and exercise. The goal was to see if these…

This study looked at how well a procedure called catheter ablation works for treating fast heart rhythms in people with congenital heart disease. Researchers treated 40 patients and followed them for one year to see if the abnormal heart rhythm came back. The goal was to understa…

This study measured levels of an inflammatory protein called HMGB1 in 74 children with congenital heart disease and pulmonary hypertension. Researchers compared these levels to those in children with heart disease alone and healthy controls. The goal was to see if inflammation pl…

This study tested whether a small, band-aid-like heart monitor (Zio patch) can be worn by children for up to 14 days. It involved 36 kids aged 1 to 17 years. The goal was to see if the patch sticks well and gives clear heart signals. The study did not test any treatment, only the…

This study tested how well an Apple Watch measures heart and fitness data compared to standard medical equipment. About 50 adults with heart conditions or athletes wore the watch during exercise. The goal was to see if smartwatches can reliably help monitor heart disease.

This study looked at whether a special MRI scan (4D Flow) can accurately measure blood flow to the lungs in people with both congenital heart disease and pulmonary hypertension. The standard test for this is a heart catheterization, which is invasive and uncomfortable. The study …

This study looked at whether giving extra oxygen to pregnant mothers carrying babies with congenital heart disease (CHD) could increase oxygen levels in the fetal brain. Researchers used ultrasound and MRI to measure changes in 53 fetuses with different types of CHD. The goal was…

This study tested whether using a contrast dye during 3D ultrasound can accurately measure the size and function of the right heart chamber in people who had surgery for congenital heart disease. 25 participants received an injection of Lumason (an ultrasound contrast agent) and …

This study looked at how different levels of ventilator pressure (PEEP) affect the heart's ability to pump blood in children under 5 with congenital heart disease who are on breathing machines. Researchers measured changes in cardiac output and right heart function in 58 children…

This study looked at 541 premature babies with a heart condition called patent ductus arteriosus (PDA). Half received ibuprofen to close the vessel, while the other half got only supportive care like fluids or diuretics. Researchers compared closure rates and complications to see…

This completed study tested whether giving families of children with long-term illnesses (like cancer, heart disease, or premature birth) a tablet computer with a special app helps them manage care at home. Researchers measured satisfaction, cost-effectiveness, and how well famil…

This study tested whether using cardiac MRI (a type of scan without radiation) can make heart exams safer and more accurate for children with heart failure, heart defects, or who have had a heart transplant. Researchers compared MRI results with standard biopsy and X-ray methods …

This completed study looked at how the immune system might affect the outlook for people with pulmonary arterial hypertension (PAH). Researchers took blood and skin samples from 629 participants with different types of PAH to search for specific antibodies. The goal was to better…

This study tested whether a 6-month, parent-led physical activity program at home helps young children (ages 3 months to 6 years) born with heart defects get the recommended 180 minutes of daily activity after heart surgery or catheterization. The study enrolled 43 children and f…

This study tested two ways to help 16-17 year olds with congenital heart disease learn to manage their health as they move from pediatric to adult care. One group used a smartphone app for 18 months; the other had a single teaching session with a nurse. Researchers measured chang…

This study looked at children aged 6 to 18 who had heart surgery before they were 3 months old. Researchers asked parents to fill out a questionnaire about their child's emotions, behavior, and social skills. The goal was to see if these children face any developmental challenges…

This study tested a new, portable ultrasound device that can take a picture of the heart in less than one minute. It was used on 22 infants under 1 year old with congenital heart disease. The goal was to see if the new device's images were as good as the standard ultrasound image…

This study surveyed 106 pediatric cardiologists to understand what they know, think, and do about cardiac rehabilitation for children with congenital heart disease. The goal was to find out why this helpful therapy is underused. Researchers used a questionnaire based on the World…

This study looked at 38 infants under 1 year old with congenital heart disease who needed heart surgery. The goal was to understand why some babies get brain injuries during surgery and to gather data for developing better monitoring tools. Researchers used MRI scans and blood sa…

This study tested a new imaging system called VERAFEYE in 18 people already scheduled for standard heart procedures like ablation or closure. Doctors used the device during the procedure and gave feedback via a questionnaire. The goal was to gather information to improve the syst…

This study collected blood and tissue samples from 91 adults with aortic valve disease to look for genetic differences that might explain why some develop aortic aneurysms. Researchers compared gene activity in people with bicuspid valves, tricuspid valves, and healthy controls. …

This study tested a noninvasive monitor that uses light to measure oxygen levels in the liver of children with heart conditions. Researchers wanted to see if this method could replace the usual needle-based blood draw. The study included 100 children undergoing heart catheterizat…

This study tested whether a special belt that creates images of the lungs (Electrical Impedance Tomography) can safely help doctors choose the best pressure settings on a breathing machine for infants under 3 years old. The study included 14 children with various serious conditio…

This study measured how often teenagers develop chronic kidney disease after having heart surgery as young children. Researchers collected blood and urine samples from 120 teens aged 10 to 15 during their regular heart check-ups. The goal was to find out how common kidney damage …

This study looked at whether orienteering (a navigation-based walk) is as good as regular walking for heart rehab. 40 people with stable heart disease took part. Researchers measured heart rate and enjoyment during both activities. The goal was to see if orienteering could be a f…

This study looked at whether viral infections and diabetes in pregnant women are linked to congenital heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather knowledge for future lar…

This study tested whether 3D-printed heart models or augmented reality (AR) help first-year medical students understand two rare heart defects better than traditional slide lectures. 26 students took a quiz before and after learning with one of the three methods. The goal was to …

This study looked at 60 children having heart surgery with a bypass machine. It compared two types of filters—hemofilters and hemodialyzers—to see which one better removes inflammatory substances called cytokines. The goal was to find out if the cheaper hemodialyzer could be a sa…

This completed study looked at 800 children who survived blood cancer to see if having a congenital heart defect raises their risk of death or other health problems later in life. Researchers also checked for shared genetic links between the two conditions. The goal is to better …

This study looked at brain scans of 195 young adults (ages 18-30) with moderate to severe congenital heart disease to find signs of brain injury. The goal was to see if these brain changes could help predict memory or thinking problems later in life. No new treatments were tested…

This study looked at whether near-infrared spectroscopy (NIRS), a non-invasive light-based monitor, can detect changes in a common heart condition in very premature babies. Researchers measured oxygen levels in the brain and kidneys of 26 babies born before 32 weeks and compared …

This study looked at 40 children with autism and 40 healthy children, ages 5 to 10, to see how posture, hand function, and sensory processing affect nutrition. Researchers measured head posture, balance, hand strength, and feeding behaviors. They found that children with autism h…