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Can a smarter ventilator setting help kids breathe easier after heart surgery?

NCT ID NCT07066748

Knowledge-focused Sponsor: Alexandria University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial tests two methods for taking children off mechanical ventilation after heart surgery: pressure support ventilation (PSV) and automatic tube compensation (ATC). The goal is to see which approach reduces the work of breathing and improves lung function. The study includes children aged 2 to 10 who are ready to begin weaning. By comparing these techniques, researchers hope to find a safer, faster way to remove breathing support.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
two weaning methods: pressure support ventilation (PSV) and automatic tube compensation (ATC)
What this could lead to
If one method proves better, it could reduce time on ventilators and lower complication risks for children after heart surgery.
What could go wrong
This is a small, early-stage trial with only 34 children, so results may not apply broadly. Both methods are already in use, so major breakthroughs are unlikely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

34 people

The number who actually took part.

Started

Aug 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 10 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 2-10years. 2. Both sex. 3. after fulfilling weaning criteria 4. being pain free (observational pain/discomfort scale \< 4). the weaning criteria; which include: low mandatory ventilator rate \[6-8\] or less; fraction of inspired oxygen (FIO2) ≤ 40; level of positive end expiratory pressure (PEEP) \[3-5 cmH2O\] guided by pressure/volume loop; reversal of the cause of postoperative mechanical ventilation; oxygenation index (OI) (mean air way pressure × FIO2/PaO2) \< 5; dynamic compliance (Cdyn) \> 1 ml/ cmH2O/kg Exclusion Criteria: 1. Duration of mechanical ventilation is more than 48 hours 2. Patients on high inotropic support (unstable hemodynamics) 3. Patients with disturbed conscious level 4. Patients with palliative cardiac shunting procedures (e.g., BT shunt, Glenn shunt).

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Conditions

The condition(s) this trial relates to.

congenital heart disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pediatric cardiac surgery Weaning mechanical ventilation

Contacts and locations

Locations

  • Faculty of medicine ,Alexandria university

    Alexandria, Alexandria Governorate, 21521, Egypt

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Other studies related to the condition(s) this trial covers.