Can a common painkiller prevent a heart problem in preemies?
NCT ID NCT07067177
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether giving paracetamol (a common painkiller) early can prevent a heart opening called PDA from staying open in extremely premature infants (born before 30 weeks or under 1250 grams). 40 babies were randomly given either paracetamol or the standard drug indomethacin. The goal was to see which drug works better at closing the opening, with follow-up including heart scans and blood tests.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
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40 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Up to 6 hours
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * gestational ages of \<30 weeks or birth weight below 1250 gm * inborn babies * authorization to perform the study signed by one of the parents after receiving enough information about the condition Exclusion Criteria: * Outborn babies * The presence of a significant birth defect or a congenital anomaly * Clinical instability that can lead to rapid death
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Al Ahli Hospital
Hebron, Palestinian Territories
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Makassed
East Jerusalem, Palestinian Territories
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Palestine Medical Complex
Ramallah, Palestinian Territories
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Tiny heart, tiny device: new hope for premature babies
- Simple blood test may spot heart risk in preemies
- Could a steroid shot help tiny preemies survive shock?
- Could a common painkiller replace ibuprofen for preemie heart treatment?
- Drug cocktail may save tiniest Babies' hearts and lungs