Congenital heart disease
MONDO:0005453A heart disease that is present at birth. Representative examples include atrial septal defect, ventricular septal defect, tetralogy of Fallot, and patent foramen ovale.
Also known as: heart malformation, congenital anomaly of heart, congenital heart defect, congenital heart defects, Abnormality, heart, abnormalities, heart, defect, congenital heart, defects, congenital heart
419 clinical trials for this condition and its sub-types, 269 tagged with Congenital heart disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Congenital heart disease
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Heart septal defect 3 trials · 94 incl. sub-types
3 sub-types
- Atrial septal defect 45 trials · 78 incl. sub-types Sub-types →
- Ventricular septal defect 24 trials · 26 incl. sub-types Sub-types →
- Familial atrioventricular septal defect 0 trials Sub-types →
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Tetralogy of fallot 34 trials
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Syndromic congenital heart disease 0 trials · 31 incl. sub-types
8 sub-types
- NOTCH1-related AOS spectrum disorder 0 trials · 16 incl. sub-types Sub-types →
- Hypoplastic left heart syndrome 10 trials Sub-types →
- Left ventricular noncompaction 3 trials · 4 incl. sub-types Sub-types →
- Dextrocardia 1 trial
- Char syndrome 0 trials
- Atrial septal defect, coronary sinus type 0 trials
- Congenital heart disease with heterotaxy syndrome 0 trials
- Scimitar syndrome 0 trials
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Patent ductus arteriosus 28 trials
4 sub-types
- Char syndrome 0 trials
- PDA1 0 trials
- Patent ductus arteriosus 2 0 trials
- Patent ductus arteriosus 3 0 trials
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Persistent truncus arteriosus 8 trials
2 sub-types
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Coronary artery congenital malformation 3 trials · 4 incl. sub-types
9 sub-types
- Aortopulmonary coronary arterial course 1 trial
- Stenosis or atrophy of the coronary ostium 1 trial
- Abnormal number of coronary ostia 0 trials
- Anomalous left coronary artery from the pulmonary artery 0 trials
- Congenital coronary artery aneurysm 0 trials
- Coronary arterial fistulas 0 trials
- Coronary artery intramyocardial course 0 trials
- Intramural coronary arterial course 0 trials
- Malposition of the coronary ostium 0 trials
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Congenital pulmonary veins anomaly 0 trials · 3 incl. sub-types
4 sub-types
- Congenital pulmonary venous return anomaly 0 trials · 3 incl. sub-types Sub-types →
- Alveolar capillary dysplasia with misalignment of pulmonary veins 0 trials
- Alveolar capillary dysplasia without misalignment of pulmonary veins 0 trials
- Congenital alveolar dysplasia 0 trials Sub-types →
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4 sub-types
- Congenital heart defects, multiple types, 6 0 trials
- Congenitally uncorrected transposition of the great arteries with cardiac malformation 0 trials
- Congenitally uncorrected transposition of the great arteries with coarctation 0 trials
- Isolated congenitally uncorrected transposition of the great arteries 0 trials
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Structural congenital heart disease, multiple types - GATA4 0 trials · 1 incl. sub-types
3 sub-types
- Atrial septal defect 2 1 trial
- Atrioventricular septal defect 4 0 trials
- Ventricular septal defect 1 0 trials
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1 sub-type
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GATA6-related congenital heart disease with or without pancreatic agenesis or neonatal diabetes 0 trials
2 sub-types
- Atrial septal defect 9 0 trials
- Atrioventricular septal defect 5 0 trials
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2 sub-types
- Char syndrome 0 trials
- Patent ductus arteriosus 2 0 trials
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Aortic valve atresia 0 trials
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8 sub-types
- MYH-6 related congenital heart defects 0 trials
- Congenital heart defects, multiple types, 2 0 trials
- Congenital heart defects, multiple types, 3 0 trials
- Congenital heart defects, multiple types, 4 0 trials
- Congenital heart defects, multiple types, 5 0 trials
- Congenital heart defects, multiple types, 6 0 trials
- Congenital heart defects, multiple types, 8, with or without heterotaxy 0 trials
- Congenital heart defects, multiple types, 9 0 trials
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Mehta lewis patton syndrome 0 trials
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Mitral atresia disorder 0 trials
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Tricuspid atresia 0 trials
Most studied deeper sub-types
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App-Based exercise program aims to strengthen hearts in congenital disease
Disease control Stopped earlyThis study tests a remote, app-enabled exercise program designed for people aged 10 to 50 with congenital heart disease. Participants use a smartphone app with exercise modules and wearable devices to track heart rate and progress. The goal is to see if this approach can safely i…
Sponsor: Duke University • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
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Heart drug study halted early: what we know
Disease control Stopped earlyThis study tested an experimental drug called CRD-4730 in people with a rare inherited heart rhythm disorder (CPVT) that can cause dangerous fast heartbeats. Seven adults received two different doses of the drug and a placebo to check safety and how the body processes it. The stu…
Phase 2 • Sponsor: Cardurion Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Abandoned study: can a common painkiller help close a tiny heart vessel in preemies?
Disease control Stopped earlyThis study tested whether adding acetaminophen to standard ibuprofen treatment could better close a blood vessel (ductus arteriosus) that stays open too long in very premature infants. The trial was planned for preterm babies born at or before 27 weeks and 6 days who needed breat…
Phase 2 • Sponsor: University of South Alabama • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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Which heart device lead lasts longest in kids? study aims to find out
Disease control Stopped earlyThis study looked at two types of implantable cardioverter defibrillator (ICD) leads in children and patients with congenital heart disease. The goal was to see which lead type lasts longer without breaking and is easier to remove if needed. The trial was terminated early, so res…
Sponsor: Charles Berul • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Heart hole closure for migraines? tiny study halted early
Symptom relief Stopped earlyThis study tested whether closing a small hole in the heart (called a PFO) with a device could reduce migraine headaches. It planned to compare the real procedure to a sham (fake) procedure in adults aged 18-55 with frequent migraines. However, the study was stopped early after e…
Sponsor: W.L.Gore & Associates • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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Can a brain zap and computer game sharpen aging minds?
Symptom relief Stopped earlyThis study tested whether combining a computer-based speed-of-processing training with a gentle electrical brain stimulation (alpha-tACS) could improve how quickly people with mild cognitive impairment process visual information. The trial planned to enroll 40 adults aged 65 and …
Sponsor: Portucalense University • Aim: Symptom relief
Last updated Jun 26, 2026 16:29 UTC
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New MRI technique could make heart procedures safer and faster
Knowledge-focused Stopped earlyThis study tests whether special low-energy MRI settings can make it safe to use guidewires during heart catheterization. Guidewires help position catheters but can heat up in standard MRI. Researchers will enroll 22 adults who need a right heart catheterization to see if this ap…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Jul 17, 2026 00:00 UTC
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Dopamine may unclog lymphatic system in rare heart complication
Knowledge-focused Stopped earlyThis study looks at whether dopamine can improve lymph flow in people who developed protein-losing enteropathy (PLE) after Fontan surgery for single-ventricle heart disease. PLE is a serious complication where proteins leak into the gut, possibly due to poor lymphatic function. R…
Sponsor: University of Michigan • Aim: Knowledge-focused
Last updated Jul 16, 2026 00:00 UTC
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Wireless heart monitor for infants tested, but study ends early
Knowledge-focused Stopped earlyThis study aimed to see if a wireless sensor could collect health information from babies with heart defects at home, replacing wired devices. Only 2 infants were enrolled before the study was stopped. The goal was to understand if the wireless device was easy to use and worked w…
Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC