Cognitive disorder

This trial tests a brain stimulation technique called sequential dual-site accelerated theta burst stimulation (SD-aTBS) in adults with schizophrenia who have cognitive impairment. The treatment targets two brain networks involved in thinking and memory. Researchers will compare …

This study tests whether a robotic surgical system can safely perform delicate microsurgery on deep lymph nodes in the neck of people with Alzheimer's disease. The idea is that improving lymph drainage from the brain might help clear harmful proteins linked to Alzheimer's. The tr…

This study compares two types of cognitive-based balance training for people with Parkinson's disease: one using virtual reality (VR) and the other combining balance exercises with mental tasks like counting. Thirty-four participants aged 40-80 will do 16 sessions over 8 weeks. R…

This study tests if special reflective roof coatings can lower indoor temperatures and improve health in Fiji. About 800 households will receive either a cool roof or usual care. Researchers will measure heart rate, blood sugar, depression, and other heat-related symptoms to see …

This study will test whether applying a special heat-reflecting coating to roofs can improve the health and well-being of 800 households in Colima, Mexico. The coating is designed to keep homes cooler indoors, which may help lower heart rate, improve blood sugar control, reduce d…

Researchers are checking whether an Indonesian version of the Oxford Cognitive Screen-Plus accurately measures thinking skills in people who have had a stroke. The study enrolls 75 adults who can read and speak Indonesian and are in the subacute or chronic phase after stroke. Par…

Researchers at the University of Wisconsin, Madison are testing a decision-support tool that helps primary care providers talk with patients about blood biomarker testing for Alzheimer's disease. The tool is a flowchart that gives clear information about the Phospho-Tau blood tes…

This study is testing a new cognitive assessment called the ExéSem battery, designed to help doctors tell the difference between language problems caused by memory loss versus those caused by thinking difficulties. Researchers will enroll 140 people, including those with Alzheime…

This study tests a new, non-invasive eye scan that uses artificial intelligence to look for changes linked to Alzheimer's disease. Researchers will compare the scan results with blood tests in 200 UAE adults who have mild memory problems. The goal is to see if this quick, painles…

This study tests a 12-week remote program for adults aged 60-75 at risk of cognitive decline. The program includes aerobic exercise, cognitive training, and education on healthy aging, all delivered through a website. Researchers will measure whether the program improves memory, …

This trial investigates whether a home-based self-management program called HOBSCOTCH can improve thinking, memory, and quality of life in young adults (ages 18–29) and youth (ages 13–17) with epilepsy. Participants attend nine weekly one-on-one coaching sessions by phone or comp…

This pilot study explores whether a personalized telerehabilitation program can help adults who notice cognitive slips in daily life. Participants include older adults and adults with Ehlers-Danlos Syndrome who report subjective cognitive complaints. Over six weeks, they receive …

This trial tests a mobile app called the Social Reminder System, designed to help people with memory concerns stay socially engaged. The app sends reminders on a home tablet when a trusted friend or family member is nearby, potentially encouraging more visits and interactions. Re…

This study tests whether taking creatine supplements before surgery can help protect thinking, memory, and attention in older adults. Creatine is widely used for muscle performance, but may also support brain health. Researchers will give creatine to 80 older adults scheduled for…

This study tests whether a 12-week program of adaptive computerized cognitive training—brain exercises that automatically adjust to each person's performance—can improve memory, attention, and other thinking skills in older adults with mild cognitive impairment. Participants, age…

This randomized trial tests whether adding animal-assisted therapy (AAT) — structured sessions with a trained dog and/or rabbits — to standard rehabilitation can improve motor abilities, independence, and quality of life in older adults with dementia who are hospitalized in a med…

This study tests whether a gentle, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can improve quality of life, reduce fatigue, and clear brain fog in people with long COVID. Twenty adults with persistent fatigue or cognitive problem…

This study will test whether eating 1.5 cups of mango every day for 12 weeks can improve immune function and thinking skills in healthy young adults aged 18 to 30. Researchers will measure changes in immune cells, inflammation, and cognitive test scores. The goal is to see if thi…

This study looks at whether moderate-intensity aerobic calisthenics, like the Jiamusi Happy Dance Steps, can improve thinking skills and walking speed in rural older adults with motoric cognitive risk syndrome (MCR), a condition that raises dementia risk. Over 12 weeks, 106 parti…

This study tests whether adding nitrous oxide (EMONO) to standard antidepressants can reduce depressive symptoms in nursing home residents aged 60 and older who have moderate to severe dementia. Participants receive either EMONO or medical air (placebo) via a face mask over sever…

This study tests whether a personalized virtual reality program that uses sights, sounds, smells, and tastes can reduce apathy in older adults with cognitive impairment living in nursing homes. Ten participants will attend weekly sessions for six weeks, reliving meaningful memori…

This study tests whether an AI-powered chatbot can help adults aged 65 and older start and stick with a personalized exercise program. Researchers will measure changes in cognitive function, like memory and attention, over 24 weeks. Ninety participants will either get the chatbot…

This early study tests whether a low-level magnetic therapy device, used at home, is safe and practical for people with cognitive issues from brain injury, Long COVID, or Alzheimer's. About 30 adults will use the device regularly and complete computer-based thinking tests. The go…

This study tests whether two food supplements—one made from olive leaf extract and another combining olive leaf with mullein extract—can help maintain memory and thinking skills in older adults with mild cognitive impairment. About 99 participants aged 60–85 will take either one …

This study tests whether minocycline, an antibiotic that reduces brain inflammation, can safely prevent or reverse memory and thinking problems in adults with sickle cell disease. About 30 participants will take either a low dose, high dose, or placebo for one year. Researchers w…

This study tests whether combining two types of non-invasive brain stimulation (tDCS and TMS) can improve memory, thinking, and movement in people who have had a stroke. Twenty-four participants will receive either real or fake (sham) stimulation daily for one week. Researchers w…

This study tests whether a gentle, non-invasive electrical brain stimulation (tACS) can improve working memory in people who have memory problems after a stroke. 24 participants will receive either real or fake stimulation for 40 minutes a day for 5 days, alongside cognitive ther…

This study tests whether a virtual cognitive behavioral therapy for insomnia (CBT-I) program, called REPAIR Sleep, can improve sleep and emotional well-being in people with dementia and their live-in caregivers. Over 5 weekly video sessions, participants learn techniques like set…

This study tests whether intensive music therapy can improve thinking skills like memory, attention, and decision-making in people recovering from a stroke. It will include 36 adults in Malaysia who had a stroke within the last 3 months and have mild to moderate cognitive problem…

This study tests whether a mobile app or virtual reality program that teaches mindfulness and breathing exercises can lower stress, burnout, and improve sleep and thinking in nurses who work rotating shifts. 300 nurses will be split into four groups: one gets health education onl…

This study will test whether doing Pilates exercises at home via video calls for 16 weeks can help people with multiple sclerosis (MS) walk farther and faster, improve balance, reduce fatigue and pain, and boost mood and thinking. About 50 adults with mild to moderate MS who can …

This study tests whether making weekly action plans for physical activity helps inactive older adults (60+) become more active and improve their memory and thinking. 148 participants will wear Fitbits for 9 months and complete brain games on their phones. Researchers compare thre…

This study tests whether two dietary supplements can help adults who are poor sleepers improve their sleep quality, thinking skills, and stress levels. Over 28 days, 68 participants will take either an active supplement or a placebo. Researchers will measure sleep efficiency, gut…

This study tests a personalized method using non-drug therapies (like music or activities) to reduce behavioral issues such as agitation and wandering in elderly people living in care homes. Researchers will compare this new approach to the usual care methods. The goal is to see …

This study looks at whether a 12-week strengthening exercise program can improve muscle strength, muscle mass, and cognitive function in people with compensated liver cirrhosis. Twenty participants will be randomly assigned to either face-to-face or home-based exercise sessions t…

This study tests whether a non-invasive brain stimulation technique called tDCS, combined with computer-based cognitive training, can improve memory, attention, and multitasking in veterans with mild traumatic brain injury and PTSD. Forty-six veterans will receive either real or …

This study will test whether different amounts of computerized brain training can improve thinking and memory in older adults with mild cognitive impairment. About 234 people aged 60 and older will be assigned to one of several training schedules over 12 weeks. Researchers will t…

This study aims to create a version of the Mini-Mental State Examination (MMSE) that works better for people in Reunion Island. The current French version has questions that don't fit local culture. Researchers will test 400 people aged 60-89, both healthy and those with Alzheime…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study looks at whether a specific type of stroke called branch atheromatous disease (BAD) is linked to cognitive decline. Researchers will follow 60 adults aged 18-80 who had this stroke, tracking their thinking and memory over a year. They will also examine if early neurolo…

This study investigates how a drug called Cobenfy KarXT, which affects the brain's cholinergic (acetylcholine) system, alters brain activity during memory and thinking tasks. About 30 people with essential tremor or epilepsy who are already scheduled for deep brain stimulation (D…

This study explores whether self-administered digital cognitive tests can accurately measure thinking skills like attention, memory, and processing speed in people with primary central nervous system lymphoma or low-grade gliomas. Participants will complete both digital tests (on…

This pilot study investigates whether exercising together or separately influences brain function, cognitive performance, mood, and parent-child connection in mother-child pairs. Mothers and their children (ages 4-12) will complete two fitness sessions—one together and one in sep…

This study will follow 500 people with severe aortic stenosis who need a heart valve replacement. Researchers want to see if a dedicated Heart Valve Unit—a team of heart specialists working together—can reduce confusion, delirium, and memory problems that sometimes happen after t…

This study looks at how the brain works when people make decisions. Researchers will work with 30 adult epilepsy patients who already have electrodes in their brains for medical reasons. While patients play a simple decision-making game, the team will track their brain activity, …

This study will test a digital platform called MEVA that measures cognitive wellness in healthy adults aged 55 to 75. Participants will complete activities and questionnaires to see how reliable and easy the platform is. The goal is to understand if the tool works well for older …

This study reviews records from 1,000 healthy adults who completed 60 sessions of hyperbaric oxygen therapy (HBOT). Researchers will compare exercise test results and thinking skills before and after treatment to see if there are any changes. The goal is to understand how HBOT mi…

This study watches 210 older adults (60+) having heart surgery to see if the anesthesia drug remimazolam affects their thinking and memory afterward. Participants answer questionnaires about confusion and mental function. The goal is to learn, not to test a new treatment.

This study checks if a Turkish version of the Physical Activity Enjoyment Scale (PACES-8) works well for adults aged 65 and older who have mild cognitive impairment. Researchers will ask 100 participants to take a 15-minute walk and then fill out the scale. They will also retest …

This study will create and test new ways to measure how thinking (neurocognitive load) affects arm and hand performance in athletes and healthy adults aged 18-40. Researchers will compare results from physical tests done with and without a mental challenge (reacting to lights) to…

This study looks at why some older people experience confusion or memory problems after major surgery. Researchers will test 40 patients aged 70 and older before and after colorectal or urological surgery. They will use memory tests and blood samples to see if they can link chang…

This study looks at how doing mental tasks—like naming objects or remembering words—changes the way people with Parkinson's disease walk. Researchers will compare 30 people with Parkinson's to healthy adults of the same age and sex. The goal is to find out which type of thinking …

This study will check if levels of Alzheimer's-related substances in the blood differ among the main ethnic groups living in central Barcelona. Researchers will also look at how age, income, education, and health conditions affect these levels. The goal is to identify barriers to…

This study aims to develop and test advanced MRI methods to study kidney disease, including in patients with chronic kidney disease, those on dialysis, and kidney transplant recipients. Researchers will also use brain MRI to explore links between kidney function and cognitive pro…

This observational study will use a non-invasive brain-computer interface and artificial intelligence to detect and record brain activity in terminally ill patients immediately after clinical death. Researchers aim to capture organized neurocognitive signals, such as gamma waves,…

This study looks at how personal traits like anxiety, self-esteem, and perfectionism influence the ability to adapt in people with alcohol use disorder. Thirty participants will complete a computer task and questionnaires in one 45-minute session. No medication or treatment is in…

This study will give 180 healthy adults a daily probiotic supplement (Lactobacillus plantarum) for 1 or 6 months. Researchers will collect blood and stool samples and run online cognitive tests to see if the supplement changes gut bacteria, blood markers, or thinking skills. The …

This observational study will follow 100 children in Denmark who receive a stem cell transplant for blood cancer or other serious blood disorders. Researchers will test their thinking skills, physical abilities, and daily activity before the transplant and for one year after. The…

This study will follow 5,160 pregnant women in France who have HIV, hepatitis B, hepatitis C, or an arbovirus infection (like Zika or dengue), along with their children, for up to 7 years. Researchers want to learn how these viruses and their treatments affect pregnancy, the moth…

This study aims to find out how reliable the DiaMem memory test is when taken multiple times. Researchers will have 30 adults aged 60 or older take memory tests once a day for 6 days. The goal is to see if scores stay consistent, which would help doctors better assess memory prob…

This study will look at how getting only 3 hours of sleep (instead of 8) affects blood sugar, blood vessel stiffness, and thinking skills in healthy adults aged 20-45. Researchers will also test if regular exercise can help protect against these negative effects. The goal is to b…

This study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…

This study looks at how general anesthesia affects certain brain chemicals and thinking skills. Researchers will compare 160 adults having gallbladder surgery: those who have never had anesthesia before and those who have had it multiple times. The goal is to understand if repeat…

This study will follow 2,800 adults aged 55 and older in China for many years to understand how aging affects the brain and thinking skills. Researchers will collect information on diet, lifestyle, medical history, brain scans, and gut bacteria. The goal is to learn what helps pe…

This study looks at whether eye movement patterns can help detect early cognitive problems in people over 65. Researchers will use special glasses to track eye movements while participants perform visual tasks. The goal is to find a simple, non-invasive way to screen for mild cog…

This study looks at 45 adults with migraine and a small hole in the heart (PFO). Researchers will use brain scans and thinking tests to see if closing the hole changes brain activity, mood, and migraine symptoms over a year. The goal is to understand the link between PFO and migr…

This study will check how common thinking and memory problems are in people who have had their first stroke. Researchers will evaluate 400 adults aged 18 to 60 within three months of their stroke. The goal is to better understand the impact of stroke on the brain, not to test a n…

This study tests whether low-intensity focused ultrasound can temporarily alter brain activity in 80 healthy adults. Participants receive MRI and CT scans, then ultrasound to the brain, followed by fMRI to measure changes in thinking and resting brain signals. The goal is to unde…

This study tests whether a mild electrical pulse to the ear (called taVNS) can temporarily improve thinking skills like attention and memory in healthy adults aged 18-30. Each of the 60 participants will receive both the real stimulation and a fake (sham) version in separate sess…

This pilot study tests whether a 6-week digital health literacy program delivered through face-to-face sessions and WhatsApp activities can help older adults in Singapore improve their digital health skills and support brain function. Researchers will compare 140 participants age…

This study will follow 175 children and young adults who had a bone marrow transplant before age 18. Researchers will test their thinking, memory, and attention skills, and check for links to physical health issues like metabolism and fitness. The goal is to find early warning si…