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Brain zapping at home: new hope for veterans with memory problems

NCT ID NCT07414537

Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a non-invasive brain stimulation technique called tDCS, combined with computer-based cognitive training, can improve memory, attention, and multitasking in veterans with mild traumatic brain injury and PTSD. Forty-six veterans will receive either real or fake tDCS for 20 minutes a day over 10 days, while doing brain exercises on a phone app. The goal is to see if this remote, at-home treatment can safely boost cognitive function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS) device
What this could lead to
If it works, this could offer a safe, at-home way to boost thinking skills in veterans with brain injury and PTSD.
What could go wrong
This is a small, early-phase trial with only 46 participants. The sham control may show no difference, and results may not apply to all veterans.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 46 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2027

An estimate. Start dates often move.

Expected to finish

Nov 2030

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * History of chronic mTBI as measured by Ohio State University Traumatic Brain Injury Identification Method * mTBI occurred \> 5 years prior to study enrollment * History of PTSD with symptoms within the last month as confirmed PTSD Checklist (past month) score greater than or equal to 33, * Cognitive impairment as defined by telephone Montreal Cognitive Assessment \< 19 * No history of reported or documented age-related or neurodegenerative condition * Access to internet for 1 hour per day * Willing and able to comply with all study related procedures and capable of independently reading and understanding study materials and providing informed consent. Exclusion Criteria: * Skin lesions at the stimulation site that may increase conductance * Metallic objects in the face or head (e.g. braces, fillings, implants) * Pregnancy/lactation or planning to become pregnant during study * History of other significant neurological disorders including seizure disorder, central nervous system tumors, stroke, cerebral aneurysm * History of primary psychotic disorder, bipolar I disorder, active substance use disorder (moderate or greater, measured by Drug Abuse Screening Test-10) * Active suicidal intent or plan, measured by Columbia-Suicide Severity Rating Scale * Other conditions or circumstances that, in the opinion of investigator team, have the potential to prevent completion and/or have a confounding effect on outcome assessments. * Unable to tolerate 2mA transcranial direct current stimulation (tDCS)

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Conditions

The condition(s) this trial relates to.

brain injury cognitive disorder Cognitive Dysfunction post-traumatic stress disorder traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain injuries Cognition Stress disorders, post-traumatic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA

    Philadelphia, Pennsylvania, 19104-4551, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.