Olive leaf and mullein: a natural boost for aging brains?
NCT ID NCT07586410
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether two food supplements—one made from olive leaf extract and another combining olive leaf with mullein extract—can help maintain memory and thinking skills in older adults with mild cognitive impairment. About 99 participants aged 60–85 will take either one of the supplements or a placebo daily for 6 months. Researchers will measure changes in cognitive function and quality of life, and monitor for side effects.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 99 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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Nov 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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60 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Participants of both sexes who meet the following characteristics will be included in the study: * aged between 60 and 85 years; * able to understand and sign the informed consent form; * able to understand and comply with the protocol requirements; * negative HIV test; * score between 20 and 25 on the Montreal Cognitive Assessment (MoCA) questionnaire (Nasreddine et al., 2005). * total Instrumental Activities of Daily Living (IADL) + Activities of Daily Living (ADL) score of 14; * Geriatric Depression Scale (GDS) score between 0 and 5; * Generalized Anxiety Disorder (GAD-7) score between 0 and 4; * not currently taking or taking any medications, including antidiabetics, drugs that affect the nervous system such as antidepressants, anxiolytics, or opioids; * who are not taking antibiotics or have not taken antibiotics in the last four weeks, or in the last 6 months, based on the intensity and duration of antibiotic treatment. Subjects with the following characteristics will be excluded from the study: * aged \< 60 and \> 85 years; * individuals with a MoCA questionnaire score \< 20 and \> 26; * Geriatric Depression Scale (GDS) score \> 5; * Generalized Anxiety Disorder (GAD-7) score \> 4; * who show no willingness to cooperate; * who have difficulty traveling to the referral facility on time; * who are deemed unsuitable by the investigator due to the presence of other conditions deemed incompatible with enrollment and which require pharmacological treatments (e.g., active systemic diseases, diabetes, neurological and psychiatric conditions, including cognitive disorders that prevent completion of the questionnaires); * affected by HIV-acquired immunodeficiency; * individuals with severe visual and hearing impairments; * with known allergies to ingredients of the investigational products (active or placebo); * who abuse alcohol, drugs, nicotine, caffeine, or theine; * who take medications.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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COMEGEN Soc. Coop. Sociale, Napoli, 80126
Naples, Italy
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