Uppsala University

This study tests whether pivmecillinam pills work as well as standard antibiotics for treating febrile urinary tract infections (kidney infections) in adults. Participants who have already improved after 2-4 days of IV antibiotics will take pivmecillinam or continue standard care…

This study tests if a special vacuum dressing (negative pressure wound therapy) can reduce wound problems like infection or reopening after emergency belly surgery. About 720 adults with a large midline incision will be randomly assigned to get either the vacuum dressing or a reg…

This study compares 6 months versus the standard 12 months of immunotherapy (nivolumab or pembrolizumab) for people with high-risk melanoma that has been surgically removed. The goal is to see if the shorter treatment is equally effective at preventing the cancer from coming back…

This study looks at people with stage 4 pancreatic neuroendocrine tumors (pan-NET) that have spread. It compares two approaches: having surgery to remove as much tumor as possible (plus optional drug treatment) versus drug treatment alone. The goal is to see which helps people li…

This study tests a 10-session group therapy that helps teens with autism change how they think about their thoughts to reduce anxiety and depression. Researchers will check if the therapy is practical and acceptable for 36 participants aged 15-18. The goal is to see if it improve…

This study tests whether helping people sleep better for four weeks before knee or hip replacement surgery can reduce pain and speed up recovery afterward. One hundred adults with insomnia symptoms will receive either a brief sleep therapy or sleep education before their operatio…

This study tests two ways to manage pain after open abdominal surgery in children aged 1 to 15. One method uses a nerve block (TAP-block), the other delivers numbing medicine through a small tube placed in the wound. The goal is to see which approach reduces the need for strong p…

This study aims to find out if spinal fusion surgery truly helps people with long-term low back pain. Ninety adults with persistent pain will undergo surgery, but half will receive a placebo procedure without fusion. Neither the patients nor their caregivers will know which group…

This study is testing a Swedish version of a short 8-question shame scale called the EISS. Researchers will ask 350 adults (300 from the public and 50 from clinics) to fill out the questionnaire along with other surveys. The goal is to see if the Swedish version accurately measur…

This international study will track 2,000 children aged 0-16 who have noncardiac surgery to see how often they develop acute kidney injury (AKI). Researchers will also test urine biomarkers as early warning signs. The goal is to better understand risk factors and improve preventi…

This study from Uppsala University looks at how a low-fat, fiber-rich diet versus a high-fat, Western-style diet affects sleep quality, heart rate, and metabolism. Twenty-four healthy young adults will follow each diet for about a week, then spend two days in the lab for detailed…

This study is watching how well robotic-assisted screw placement works compared to traditional methods in spine surgery. Researchers will track screw accuracy, how quickly surgeons learn the robot, and whether patients need another surgery within two years. Over 7,000 participant…

This study is looking for early signs of acute kidney injury (AKI) in patients with sepsis or after major surgery. Researchers will measure inflammatory markers in urine, blood, and sputum to see if they can predict kidney damage. The goal is to better understand how inflammation…

This study looks at how the body processes antibiotics in people with a serious heart infection called endocarditis. Researchers will measure drug levels in 150 patients across four Swedish hospitals to understand why some patients get too little or too much medication. The goal …

This study looks at whether measuring the water outside cells (extracellular water) can help doctors understand fluid status in sepsis patients with unstable blood pressure. About 20 adults with sepsis in the ICU will have standard care plus extra water measurements. The goal is …

This study looks at adults with a specific type of broken collarbone (displaced lateral clavicle fracture) to see if treating it without surgery works just as well as surgery. About 96 participants will be randomly assigned to either have surgery or non-surgical care. The main go…

This study interviews 30 women who have experienced intimate partner violence and are taking part in a resilience-focused program at Uppsala University Hospital. Researchers want to learn how well the program meets each woman's needs and how it affects their recovery. The goal is…

This study aims to find sensitive blood markers that show brain injury caused by cancer treatments in children with brain tumors. Researchers will compare children who receive different treatments (surgery, chemotherapy, radiation) and healthy children. Participants give blood sa…