Tianjin Medical University Cancer Institute And Hospital

This study tests whether adding two drugs (serplulimab and nimotuzumab) to standard chemoradiation can improve outcomes for people with a certain type of esophageal cancer that can be surgically removed. About 46 adults will receive the combination treatment before surgery. The m…

This study tests a new treatment for people with a specific type of lung cancer (EGFR-mutated) that has spread to the brain and causes symptoms. It combines whole-brain radiation (with protection for memory areas) and a daily targeted pill called osimertinib. The goal is to see i…

This study tests two surgical techniques for bile duct cancer that has spread to nearby lymph nodes. One method removes the bile duct completely to take out all affected lymph nodes, while the other leaves the bile duct in place but may leave some lymph tissue behind. The goal is…

This study tests whether adding radiation therapy to standard chemotherapy after pancreatic cancer surgery can delay or prevent the cancer from returning. It involves 288 high-risk patients who have had their tumor removed. The goal is to see if this combination improves how long…

This study is for people with stage 2 to 3B lung cancer who had surgery after chemo-immunotherapy but still had cancer cells left. It tests whether adding a special immune cell treatment (L-TIL) plus another immunotherapy drug (tislelizumab) can keep the cancer from returning. Ab…

This study tests a two-step approach for people with advanced esophageal cancer that cannot be removed by surgery. First, patients receive a combination of immunotherapy and chemotherapy. Then, based on how well the tumor responds, they get either the same drugs plus radiation or…

This study tests a new combination of three drugs (chidamide, rituximab, and polatuzumab vedotin) in elderly patients (70+ or 60-69 with frailty) who have a specific, aggressive type of lymphoma called double-positive DLBCL and have not had any prior treatment. The goal is to see…

This study tests a combination of four drugs (sintilimab, ipilimumab, cetuximab, and dabrafenib) in people with a specific type of advanced colorectal cancer that has a BRAF V600E mutation and is microsatellite stable (MSS). These cancers are hard to treat and don't respond well …

This study tests whether adding the drug serplulimab to standard chemoradiotherapy after surgery can help prevent cervical cancer from returning in patients with multiple risk factors. About 134 women aged 18-65 with PD-L1 positive cervical cancer will be randomly assigned to rec…

This study tests whether a mix of liver-directed chemotherapy, two drugs (durvalumab and bevacizumab), and focused radiation can shrink advanced liver cancer enough to allow surgery. About 30 adults with liver cancer that cannot currently be removed will receive these treatments …

This study looks at two treatment options for people with a type of esophageal cancer that has shrunk after initial chemotherapy and immunotherapy. One group will have surgery to remove the cancer, while the other will get stronger chemoradiotherapy instead. The goal is to see if…

This study tests whether adding the drug serplulimab to standard chemoradiotherapy can help people with locally advanced cervical cancer live longer without their disease getting worse. About 216 women aged 18-75 with untreated cervical cancer will take part. The main goal is to …

This study tests a new treatment for people with advanced non-small cell lung cancer that no longer responds to PD-1 inhibitors. The treatment combines a special immune cell therapy (WAST cells) with the chemotherapy drug docetaxel. About 31 participants will receive this combina…

This study tests a combination of three treatments (furmonertinib, chemotherapy into the spinal fluid, and precise radiation) as a first treatment for people with a specific type of lung cancer (EGFR mutation) that has spread to the brain and its lining. About 30 adults will take…

This early-stage trial tests a new cell treatment called GK01, given alone or with chemotherapy, for people with advanced solid tumors like pancreatic or stomach cancer. The main goal is to check safety and how the body handles the treatment. About 15 participants will be enrolle…

This study tests a combination of two drugs (Sacituzumab Tirumotecan and Furmonertinib) in 25 people with advanced non-squamous non-small cell lung cancer that has an EGFR gene mutation and has stopped responding to standard treatments. The goal is to see if the combo can shrink …

This study tests whether adding an immunotherapy drug (sintilimab) to short-course radiation and chemotherapy can improve long-term survival in people with a common type of locally advanced rectal cancer (MSS type). About 130 adults will be randomly assigned to receive the new co…

This study tests whether adding the immunotherapy drug iparomlimab after standard chemoradiation can help older adults (70+) with inoperable esophageal cancer live longer without the disease getting worse. About 52 participants will receive the drug for one year after chemoradiat…

This study tests a special radiation method called lattice radiation therapy (LRT) combined with immunotherapy for people with advanced solid tumors that have not responded to standard treatments. The LRT delivers high-dose radiation to specific spots inside the tumor while keepi…

This study tests a new approach for people with advanced non-small cell lung cancer whose disease has worsened after initial immunotherapy and chemotherapy. Participants will receive a combination of microwave ablation (using heat to destroy tumors), the immunotherapy drug tislel…

This study tests a combination of four drugs (chidamide, dinutuximab beta, irinotecan, and temozolomide) in 27 children whose neuroblastoma has come back or not responded to standard treatment. The goal is to see how well the drugs shrink or control the cancer, while closely watc…

This study tests whether giving additional immune therapy after surgery can help prevent head and neck cancer from coming back. It includes 268 adults who already had a good response to initial treatment. The goal is to see if this approach improves survival and is safe.

This study tests a combination of four drugs (immunotherapy and targeted therapy) plus liver-directed chemotherapy to shrink advanced liver cancer that cannot be surgically removed. The goal is to make enough tumors shrink so that patients can undergo curative surgery. About 43 a…

This study tests whether the drug anlotinib can help prevent lung cancer from returning in patients who still had cancer cells after surgery and chemotherapy. About 64 adults with stage IIA-IIIA non-small cell lung cancer will take anlotinib capsules. The main goal is to see how …

This study is testing a combination of three drugs (liposomal irinotecan, capecitabine, and enlonstobart) plus a short course of radiation before surgery for people with locally advanced rectal cancer. The goal is to see if this approach can make tumors disappear completely or le…

This study tests a mix of four drugs (iparomlimab, tuvonralimab, chidamide, and chemo) as a first treatment for people with metastatic pancreatic cancer that has spread. The goal is to see if the combination can shrink tumors and help people live longer. About 33 adults who have …

This study tests whether women with certain aggressive breast cancers (triple negative or HER2-positive) can safely avoid breast surgery if their tumors disappear completely after a combination of chemotherapy and radiation. About 200 participants will receive the non-surgical tr…

This study tests whether a medicated nasal spray (dexmedetomidine) can help women feel relaxed and less anxious during breast-conserving surgery for breast cancer. About 394 women will receive either the spray or a placebo before surgery. Researchers will measure sedation levels,…

This study is testing whether a special nurse-led care plan can help people recover better after head and neck cancer surgery. The plan includes extra support from nurses, dietitians, and counselors to reduce complications and improve quality of life. About 80 adults having surge…

This study looks at how far surgeons should remove lymph nodes near the stomach during surgery for advanced stomach cancer. It involves 400 patients and aims to find the best balance between removing cancer and preserving healthy tissue. The goal is to improve surgical outcomes w…

This study looks at how well CDK4/6 inhibitors work for people with a common type of advanced breast cancer (HR+/HER2-). It will follow 245 patients to see how long the treatment controls the cancer and what options work best if the cancer stops responding. The goal is to gather …

This study tests a new AI chatbot that gives personalized health information to people with thyroid cancer before and after surgery. Researchers want to see if using the chatbot helps patients feel more ready to go home and recover better compared to standard education. About 150…

This study tests if a special belly-pressure device can reduce breathing-related tumor movement during lung cancer radiation therapy. 50 people with early-stage lung cancer will use the device to see if it helps make radiation more precise. The goal is to improve treatment accura…

This study looks at how bacteria inside tumors might help predict whether cancer treatments will work. Researchers will collect tumor samples from 90 people with stomach, colon, pancreas, or esophageal cancer before they start treatment. The goal is to find bacterial patterns tha…