New combo therapy aims to shrink liver tumors enough for surgery
NCT ID NCT07560488
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial tests a combination of four treatments—two immunotherapies (ipilimumab N01 and sintilimab), a targeted therapy (bevacizumab biosimilar), and chemotherapy directly into the liver—for people with advanced liver cancer that cannot be surgically removed. The goal is to shrink the tumors enough to allow surgery, potentially improving long-term outcomes. The study enrolls 43 adults aged 18-75 with no prior treatment for their liver cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ipilimumab N01, sintilimab, bevacizumab biosimilar, and hepatic arterial infusion chemotherapy (FOLFOX-HAIC)
- What this could lead to
- If successful, this combination could help shrink advanced liver tumors enough to allow surgical removal, potentially offering a chance at long-term control or cure for patients who currently have no surgical options.
- What could go wrong
- This is an early phase II trial with only 43 participants and no control group, so results may not apply broadly. The combination of multiple drugs also raises the risk of serious side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Tianjin Cancer Hospital Airport Hospital
RECRUITINGTianjin, Tianjin Municipality, China
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Other studies related to the condition(s) this trial covers.
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