HCC - HEPATOCELLULAR CARCINOMA

This pilot study is testing a new strategy for patients with liver cancer that cannot be surgically removed. Researchers will combine immunotherapy (which uses the body's immune system) with highly focused radiation to try to shrink tumors. The goal is to make the cancer small en…

This study is testing whether a new injection called INT001 can safely destroy liver tumors in adults who aren't candidates for surgery. Doctors will use imaging to guide a needle into the tumor and inject INT001 directly, then monitor patients for 90 days to see if the tumor is …

This is a first-in-human study to find a safe dose and see how well a new drug called TGI-5 works, both by itself and combined with an existing immunotherapy (nivolumab). It is for adults with advanced solid tumors (like lung, colon, skin, or liver cancer) that have spread and no…

This is a very early-stage study to test the safety of a new drug called GV20-0251 in adults with advanced solid tumors that have progressed despite standard treatments. The main goal is to find a safe dose by giving the drug to small groups of patients at different levels. It is…

This early-stage study is testing a new type of cancer treatment called universal CAR-T cells (REVO-UWD-03) for people with advanced liver or lung cancer. The goal is to see if this 'off-the-shelf' therapy, made from healthy donor cells, is safe and can help control these cancers…

This study is testing whether combining precise proton radiation therapy with two immunotherapy drugs can better control advanced liver cancer that cannot be surgically removed. The trial will enroll 45 patients to see if this combination is safe and more effective than current s…

This study is testing a new drug called AST-3424 for people with advanced liver cancer that has gotten worse despite treatment with modern immunotherapy drugs. It aims to see if this new drug can help patients live longer. Researchers will compare it directly to another available…

This study is testing a new drug called GV20-0251 for adults with advanced solid tumor cancers that have progressed despite standard treatments. The first part aims to find a safe dose, and the second part will see how well the drug works against several types of cancer, includin…

This study is testing whether giving two cancer drugs one after the other (sequential) works better or worse than giving them at the same time (concurrent) for people with advanced liver cancer who also have fatty liver disease. It will involve 20 participants and aims to see whi…

This study is testing if adding a targeted procedure to a two-drug combination works better for advanced liver cancer. It will compare two groups: one gets the drugs alone, and the other gets the drugs plus a procedure that delivers treatment directly to the liver tumor. Research…

This study is testing whether a newer type of CT scan, called spectral CT, can more accurately tell if a common liver cancer treatment (TACE) has worked. Researchers will compare the new scan's results to standard CT scans and to other medical tests in 250 patients. The goal is t…

This study is testing a new, more detailed type of PET/CT scan to see if it can better find and track liver cancer (HCC). It will involve 40 adults who are either newly diagnosed or suspected of having cancer that has returned or not responded to treatment. The goal is to see if …

This study aims to see if a simple blood test can tell doctors how well radiation therapy is working for liver cancer. Researchers will track tiny pieces of cancer DNA in the blood of 15 patients before, during, and after their radiation treatment. The goal is to find a better, f…