Nationwide Children's Hospital

This study tests a vaccine called PEP-CMV in 120 children and young adults with certain aggressive brain tumors (high-grade glioma, DIPG, or recurrent medulloblastoma). The vaccine targets a common virus (CMV) found in these tumors, aiming to train the immune system to attack the…

This study tests two drug combinations given after radiation for children and young adults with aggressive brain tumors (high-grade glioma or DIPG). One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The goal is to see if these combinations …

This study tests whether adding specially trained immune cells (NK cells) to standard chemotherapy can help children and young adults with sarcoma that has returned or not responded to prior treatments. About 50 participants aged 2 to 40 will receive up to 8 cycles of the combina…

This study tests the drug lorlatinib in children (ages 1 to 21) with a newly diagnosed high-grade glioma that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor and to check its safety when given with or after other …

This study is testing a drug called Lutathera in people aged 4 to 39 with certain aggressive brain tumors or meningiomas that have come back or are growing. The drug delivers radiation directly to tumor cells that show up on a special PET scan. The goal is to find the safest dose…

This study tests a drug called ACT001 in children and young adults (ages 1 to 39) with two types of aggressive brain tumors: DIPG and H3K27-altered high-grade gliomas. The goal is to see if the drug can help control the disease and improve survival. Participants will receive ACT0…

This study tests whether the drug anakinra can safely reduce severe inflammation in children with sepsis who have multiple organ failure. About 500 children in intensive care will receive either anakinra or a placebo. The goal is to improve organ function over 28 days and quality…

This study tests a drug called larotrectinib in children (up to age 21) with a rare, aggressive brain tumor (high-grade glioma) that has a specific genetic change (NTRK fusion). The goal is to see if the drug can shrink or control the tumor after two cycles, and to check its safe…

This study tests an oral drug called MEKTOVI (binimetinib) in children and young adults (ages 1 to 39) with a rare brain tumor called adamantinomatous craniopharyngioma (ACP) that has come back or is growing. The drug works by blocking certain signals that help tumors grow. The m…

This study tests a drug called tocilizumab, already used for arthritis, in children and young adults (ages 1 to 39) with a rare brain tumor called adamantinomatous craniopharyngioma that has come back or is growing. The goal is to see if the drug can shrink the tumor or stop it f…

This study looks at three common treatments for acid reflux (GERD) in babies in the NICU: letting the baby outgrow it naturally, using acid-reducing medicine (PPI), or adding rice to their formula. The goal is to see which approach helps babies feed better and have fewer symptoms…

This study looks at whether cochlear implants in children aged 13 to 20 can be programmed remotely instead of requiring an in-person visit. Researchers will measure how satisfied the children and their parents are with the remote process, and also test speech understanding using …

This study talks to parents whose children's surgeries were canceled on the day they were scheduled. The goal is to learn about the reasons behind these cancellations, especially factors that might not be obvious. About 30 parents will be interviewed in their preferred language. …

This study is for children, teens, and young adults (ages 1 to 39) newly diagnosed with a high-grade glioma, a serious type of brain tumor. Researchers will analyze the tumor's genetic makeup to see if it matches a specific treatment plan in a future study. The goal is to learn m…

This study watches how children aged 0 to 5 with LAMA2-related muscular dystrophy move and develop over two years. Researchers will test muscle function, swallowing, breathing, and collect blood samples. The goal is to learn more about the disease and prepare for future treatment…

This study aims to find the genetic causes of congenital heart disease by analyzing DNA from affected individuals and their relatives. Researchers will use whole genome sequencing to discover new genes linked to heart defects. The study enrolls people with congenital heart diseas…

This study tests whether a set of hospital improvements can help doctors treat prolonged seizures (status epilepticus) faster in hospitalized children aged 1 month to 19 years. The goal is to give the first seizure-stopping medicine within minutes to reduce the risk of brain dama…

This study is testing an online program called PLAY for caregivers of young children who have finished cancer treatment or are on maintenance therapy. The program includes online lessons and video coaching sessions to help caregivers support their child's school readiness and man…