Nationwide Children's Hospital

This study is for children with blood cancers or bone marrow disorders who need a stem cell transplant but don't have a perfectly matched donor. It tests a new method using a partially matched family donor, where certain immune cells are removed from the donated cells to help the…

This early-stage study is testing the safety of a drug called PTC596 (Unesbulin) when given alongside radiation therapy to children and young adults (ages 1 to 21) newly diagnosed with aggressive brain tumors like DIPG or high-grade glioma. The main goals are to find a safe dose …

This study looks at whether giving fentanyl test strips (FTS) and education to people who use drugs can help prevent overdoses. About 2,400 adults in Ohio who visit Project DAWN sites will take part. Researchers will track how many overdoses happen and whether the test strips hel…

This study tests whether using a fun augmented reality (AR) game called Little NIRVANA, along with numbing cream, can lower pain and anxiety for children aged 2-8 years when they get an IV in the emergency room. About 130 children will take part, and researchers will compare thei…

This study planned to test whether a pain medicine called ketorolac is safe and effective for newborns up to 3 months old after abdominal surgery. The goal was to see if it could reduce the need for stronger narcotic painkillers. However, the study was withdrawn before any babies…

This study planned to compare three different nose sprays (dexmedetomidine, fentanyl, and midazolam) for reducing pain and anxiety in young children (ages 2-6) getting stitches in the emergency room. The goal was to see which spray worked best and was safest. However, the study w…

This study tests whether playing a virtual reality game during laser procedures can lower pain and anxiety in children and young adults. About 40 dermatology patients aged 5 and older will either use VR or receive standard care. Researchers will measure pain scores and anxiety le…

This study tests a non-invasive sticker sensor (surface EMG) to measure how well nerve blocks work during surgery in children and young adults up to age 21. The sensor records muscle electrical activity before, during, and after surgery. The goal is to learn how to give nerve blo…

This study examines why Black children often report more pain after tonsil removal than White children. Researchers will analyze blood samples from 84 children aged 4-17 to find chemical differences that might explain this disparity. The goal is to better understand the biology b…

This study follows 526 preterm infants born before 30 weeks who have a common heart condition called PDA, where a fetal blood vessel stays open after birth. Researchers want to find out which babies will close this vessel on their own, so they can avoid treatments that may cause …

This study looks at how virtual reality (VR) affects the brain when children feel pain. Twenty healthy kids aged 6-17 will wear a blood pressure cuff to create mild pain and a brain scanner to measure brain activity while using VR games, watching a VR video, or playing an iPad ga…