Nationwide Children's Hospital

This study tested a drug called GM-CSF in 75 children with sepsis who had a weakened immune system (immunoparalysis) and organ failure. The goal was to see if the drug could restore their immune response and find the best dose and way to give it (by IV or injection). The study fo…

This study tested a drug called GM-CSF in 141 children with sepsis who had multiple organ failure and a weakened immune system. The goal was to see if the drug could help their organs recover better than a placebo. The trial is complete, and results will show if this approach imp…

This phase 2 trial tested a new combination of chemotherapy drugs (gemcitabine, paclitaxel, and oxaliplatin, or GemPOx) followed by high-dose chemotherapy and a stem cell transplant in 10 patients with recurrent or progressive intracranial germ cell tumors. The goal was to see ho…

This study looked at whether giving fentanyl test strips and naloxone to people in Ohio drug courts could help prevent overdoses from stimulants mixed with opioids. Over 650 adults who used stimulants in the past 6 months took part. Researchers tracked how many people used the ki…

This study looked at whether a video that teaches teens how fear and stress affect pain can help them recover from leg pain. 86 teens with leg pain for over a month took surveys and wore activity trackers. Half watched the special video, and all were followed for a year to see if…

This study tested whether a device that sends small electrical pulses to the stomach can help children with severe, long-lasting nausea and vomiting. Thirty kids who hadn't gotten better with standard treatments took part. Each child had a temporary pacing lead placed through a t…

This completed trial tested whether a nerve stimulation treatment called PTNS can help children aged 8-18 with constipation caused by pelvic floor dyssynergia. Forty participants received either real PTNS or a sham (fake) treatment to see if it improves bowel function. The goal i…

This study tested whether the drug baclofen can reduce vomiting in children with rumination syndrome, a condition where food comes back up soon after eating. Fifty children aged 4 to 18 took either baclofen or a placebo for 4 weeks. Researchers measured how many kids vomited once…

This pilot study tested whether starting physical therapy immediately after diagnosis helps adolescent athletes with spondylolysis (a stress fracture in the lower back) recover better than waiting until pain goes away. Sixty-four athletes aged 10-19 were randomly assigned to eith…

This study tested a non-invasive device that measures muscle activity to see how well nerve blocks work during surgery in children under 5. The device uses sticky patches on the skin to track the effects of spinal or caudal anesthesia. Researchers also looked at how a common addi…

This study followed 44 adults with a confirmed VCP gene mutation to learn how their disease (IBMPFD) naturally progresses over one year. Participants completed walking tests, strength assessments, and surveys about daily function and quality of life. The goal was to gather data t…

This study tested a Spanish-language app called BMT4me with 30 caregivers of children who had a bone marrow transplant. The goal was to see if the app is easy to use and acceptable for managing care after discharge. Caregivers used the app once and filled out a questionnaire to r…