Nationwide Children's Hospital

This study tested a new combination of chemotherapy drugs (GemPOx) followed by a single round of high-dose chemo and stem cell rescue in 10 children whose brain germ cell tumors had come back or continued to grow. The goal was to see how many patients responded to the treatment a…

This study tested whether the drug GM-CSF could help children with sepsis who have a weakened immune system recover from multiple organ failure. 141 children in intensive care received either GM-CSF or a placebo. The goal was to see if the drug could improve organ function and qu…

This study tested a drug called GM-CSF in 75 children with sepsis who had organ failure and a weakened immune system (immunoparalysis). The goal was to see if the drug could restore their immune response. Children received GM-CSF for 7 days, and researchers measured whether their…

This study looked at whether giving fentanyl test strips and naloxone to people in Ohio drug courts can help prevent overdoses. Over 650 adults who used stimulants like cocaine or methamphetamine took part. The goal was to see if this approach is practical and acceptable, and whe…

This study tested a treatment called gastric electrical stimulation (GES) in 30 children with severe nausea and vomiting that didn't get better with standard care. GES uses mild electrical pulses to help the stomach work better. For four days the device was off, then on for four …

This study tested a treatment called posterior tibial nerve stimulation (PTNS) for children aged 8-18 with constipation due to pelvic floor dyssynergia. The treatment uses mild electrical pulses to a nerve in the ankle to improve bowel function. 40 children were randomly assigned…

This study looked at whether teaching teens about how fear and stress affect pain can help them recover from leg injuries that didn't involve a broken bone or surgery. 86 teens aged 12-17 with leg pain for over 4 weeks watched either a special video or a standard one. Researchers…

This study tested a new rehab approach for teen athletes with spondylolysis, a stress fracture in the lower back. 64 athletes aged 10-19 were randomly assigned to start physical therapy immediately after diagnosis or wait until their pain went away. The goal was to see if startin…

This study tested whether the drug baclofen can reduce vomiting in children with rumination syndrome, a condition where food comes back up soon after eating. Fifty children aged 4 to 18 took either baclofen or a placebo for 4 weeks. The main goal was to see if more children on ba…

This study tested a Spanish-language mobile app (BMT4me) designed to help parents care for children recovering from a bone marrow transplant. Thirty Spanish-speaking caregivers used the app and rated how easy it was to use. The goal was to see if the app is helpful and acceptable…

This study followed 44 adults with a confirmed VCP gene mutation to learn how their condition (IBMPFD) naturally changes over one year. Participants completed walking tests, strength assessments, and questionnaires about daily living. The goal was to gather data on disease progre…

This study tested a non-invasive sticker-like sensor (EMG) to measure how well spinal or caudal anesthesia works in 80 children under 5 having surgery. The goal was to see if the sensor could detect when anesthesia starts, how strong it is, and how long it lasts. This was a pilot…