Nationwide Children's Hospital

This study tests a new program called PIONEER, where parents help their hospitalized infants with feeding challenges learn to eat by mouth. The goal is to see if this approach can reduce the need for long-term feeding tubes and improve swallowing reflexes. About 134 infants who a…

This study tests a drug called tovorafenib in children and young adults (ages 1 to 39) who have been newly diagnosed with a fast-growing brain tumor (high-grade glioma or DIPG) that has a specific genetic change. The goal is to see if the drug can help them live longer by targeti…

This study tests a treatment for acute myeloid leukemia (AML) that has returned or not responded to standard therapy. It uses specially engineered immune cells (CD33 CAR-NK cells) from a healthy donor to target and kill cancer cells. The trial has two phases: first to find the sa…

This study will use a special brain imaging technique (fNIRS) to measure how virtual reality (VR) changes brain activity and reduces pain in children aged 6-17 who have burn injuries. Four children will have their brain signals recorded during burn dressing changes with and witho…

This study looks at how well young children's brains work 2.5 years after treatment for a low-risk type of brain tumor called medulloblastoma. About 96 children under age 5 will receive one of two standard chemotherapy regimens. The goal is to see which treatment better protects …

This study will use a device called TetraGraph to track how quickly the muscle relaxant rocuronium takes effect and wears off in 130 surgery patients. The goal is to find the exact timing for safer breathing tube placement. Participants will be monitored during their procedure, a…