New hope for kids with deadly brain tumors: ACT001 trial launches
NCT ID NCT06838676
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an experimental drug called ACT001 in children and young adults (ages 1 to 39) with two aggressive brain tumors: DIPG and H3K27-altered high-grade gliomas. The goal is to see if ACT001 can improve survival or shrink tumors after radiation therapy. About 60 participants will be enrolled across two groups: newly diagnosed DIPG patients and those with progressive or recurrent disease.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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C.S. Mott Children's Hospital
NOT_YET_RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Philidelphia
NOT_YET_RECRUITINGPhilidelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's National Medical Center
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cincinnati Children's Hospital
RECRUITINGCincinnati, Ohio, 45229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Duke University Medical Center
NOT_YET_RECRUITINGDurham, North Carolina, 27708, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Emory University/Children's Healthcare of Atlanta
NOT_YET_RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hopp Children's Cancer Center at NCT Heidelberg (KiTZ)
NOT_YET_RECRUITINGHeidelberg, Baden-Wurttemberg, 69120, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Montreal Children's Hospital
NOT_YET_RECRUITINGMontreal, Quebec, H4A3J1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43235, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nicklaus Children's Hospital
NOT_YET_RECRUITINGMiami, Florida, 33155, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Perth Children's Hospital
NOT_YET_RECRUITINGPerth, Western Australia, 6000, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Queensland Children's Hospital
NOT_YET_RECRUITINGSouth Brisbane, Queensland, 4101, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Royal Children's Hospital
NOT_YET_RECRUITINGMelbourne, Victoria, 3052, Australia
Contact Email: •••••@•••••
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Louis Children's Hospital
NOT_YET_RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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Starship Children's Hospital
NOT_YET_RECRUITINGAuckland, Grafton, 1023, New Zealand
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sydney Children's Hospital
NOT_YET_RECRUITINGRandwick, New South Wales, 2031, Australia
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Texas Children's Hospital
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Hospital for Sick Children (SickKids)
NOT_YET_RECRUITINGToronto, Ontario, M5G1X8, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••