Institut Curie

This early-phase study tested the drug olaparib together with radiation therapy in 24 women with a hard-to-treat type of breast cancer called triple-negative breast cancer (TNBC). The main goal was to find the safest dose of olaparib when given with radiation and to watch for sid…

This study tested two different ways of giving radiation therapy to children and teens (ages 4 to 21) with a standard-risk brain tumor called medulloblastoma. The goal was to see if giving smaller, more frequent doses of radiation (hyperfractionated) works better than the usual s…

This study tested whether adding the targeted drug cetuximab to standard radiation and cisplatin chemotherapy could help control cervical cancer better than radiation and cisplatin alone. It involved 76 patients with stage IB2 to IIIB cervical cancer that could not be surgically …

This study tested whether using a special PET scan (FAZA) to find oxygen-starved, treatment-resistant cells in chordoma tumors could improve proton therapy. 64 adults with skull base, spine, or sacral chordomas received surgery followed by proton therapy guided by the scan. The g…

This early-phase study tested whether adding the immunotherapy drug nivolumab to standard chemoradiation is safe for people with locally advanced cervical cancer. Twenty-one adults took part, receiving nivolumab alongside radiation and cisplatin, followed by up to 6 months of niv…

This study tested a more intense chemotherapy plan for people aged 2 to 50 with Ewing sarcoma that has spread beyond the lungs. The goal was to see if this approach could help more patients become cancer-free for at least 18 months. The treatment combined high-dose chemotherapy w…

This study tested the safety and effectiveness of giving trastuzumab (a targeted cancer drug) directly into the spinal fluid for people with HER2-positive breast cancer that spread to the lining of the brain. The goal was to find the best dose and see if it could control the canc…

This study tested a combination of three drugs (pomalidomide, cyclophosphamide, and dexamethasone) in 100 adults with multiple myeloma whose cancer came back after their first treatment. Participants had previously received a standard three-drug regimen. The goal was to see how m…

This study looked at 155 patients with metastatic breast cancer whose original tumors were HER2-negative. Researchers checked their blood for cancer cells that had become HER2-positive. If found, patients received the targeted drug T-DM1. The goal was to see if these patients cou…

This study tested a simple, rapid PSA blood test to see if it works as well as the standard lab test for detecting prostate cancer. Researchers compared results from 94 patients using both methods. The goal was to see if the quick test could be a reliable screening tool.

This study tested whether injecting a local anesthetic (ropivacaine) during breast cancer surgery could prevent chronic pain that sometimes lingers for months. 260 women having breast-conserving surgery or mastectomy took part. The main goal was to see if fewer women reported bre…

This study tested whether a special dressing (Hydrosorb) works better than a water-based spray for treating skin irritation caused by radiation therapy in breast cancer patients. 278 women with early signs of radiation rash took part. The goal was to see which treatment better pr…

This study looked at whether adding supportive care early on helps with the emotional and practical needs of people with metastatic uveal melanoma, a rare eye cancer that has spread. 162 adults took part, some getting standard cancer care alone and others getting early supportive…

This study tested two types of nerve blocks (ESP and PVB) given before breast cancer surgery to see which one better controls pain right after the operation. 292 women took part. The main goal was to see how many patients needed morphine in the first two hours after surgery. The …

This study looked at 17 patients who used a special morphine gel to treat pain from severe radiation skin burns on the perineum. The goal was to see if the gel could reduce pain when standard painkillers weren't enough. Results focused on pain changes and whether patients could c…

This study tested whether a numbing injection (ropivacaine) around chest nerves before breast cancer surgery reduces pain right after the operation. 182 women having a lumpectomy with sentinel node biopsy took part. The goal was to see if fewer patients needed strong painkillers …

This study looked at whether a day hospital focused on integrated palliative care can improve quality of life for adults with advanced cancer. 144 patients took part. The goal was to see if this approach helps patients feel better and supports their caregivers.

This study collected urine and blood samples from 80 men, including those with prostate cancer, suspected cancer, or healthy donors. Researchers looked for genetic markers (long non-coding RNA) to help diagnose and monitor prostate cancer. The goal was to build a biological colle…

This study looked at whether giving a booklet with suggested questions helps cancer patients or their families ask more during palliative care visits. About 121 adults with advanced cancer took part. The goal was to see if the booklet improves communication and understanding of p…

This study looked at how women feel and think after getting a personalized estimate of their breast cancer risk. Researchers used a special computer model (BOADICEA) to give each woman a risk score based on her genes. The goal was to see if this personalized information changes h…

This study tested whether breast cancer gives off a unique smell that can be detected by a special sensor. Researchers collected odor samples from the hands and tumors of 35 women before and after breast cancer surgery. The goal was to see if the sensor could isolate a cancer-rel…

This study examined 130 patients with chronic wounds to see if biofilm (a slimy layer of bacteria) is present. Researchers used special microscopes to detect biofilm and compared findings with patient health records and wound care details. The goal was to learn more about how bio…

This study aimed to develop a blood test that can detect tiny bits of tumor DNA in patients with metastatic choroidal melanoma, a rare eye cancer that has spread. Researchers tested blood samples from 40 adults to see if the test could reliably find cancer DNA. The goal was to cr…

This study looked at whether measuring tumor DNA in the blood can help track uveal melanoma that has spread to the liver. Researchers took blood samples from 60 patients before and after surgery to remove liver tumors. The goal was to see if changes in tumor DNA levels could show…

This study aims to create a communication tool to help doctors and patients discuss when cancer stops responding to treatment. Researchers interviewed 128 people, including patients with certain breast cancers, metastatic uveal melanoma, and parents of children with cancer, along…

This study tested whether a special 3D ultrasound technique (Shear Wave Elastography) can accurately predict how well breast tumors respond to chemotherapy before surgery. Researchers measured tumor stiffness at several points during treatment in 140 women with locally advanced b…

This study looked at whether a blood test that measures circulating tumor cells (CTCs) can help doctors decide when to switch chemotherapy for women with metastatic breast cancer. 265 women who had already tried two chemo treatments took part. The goal was to see if using CTC cou…

This study followed nearly 2,000 healthy hospital and non-hospital workers over 12 months to see if they had antibodies against the COVID-19 virus. Participants gave blood samples at several time points, and some also had nasal swabs. The goal was to understand how long antibodie…

This small study tested whether briefly stopping blood flow to a common skin cancer (basal cell carcinoma) could temporarily increase blood supply to the tumor. In 12 adults, researchers used a laser imaging device to measure blood flow before, during, and after a 3-minute clamp …

This study tested whether choosing cancer drugs based on the genetic makeup of a patient's tumor works better than standard treatment. It included 742 adults with advanced solid tumors that had stopped responding to usual therapies. Patients were randomly assigned to receive eith…