Assistance Publique Hopitaux De Marseille

This study tested whether GLP-1 receptor agonists, a type of diabetes drug, can improve heart function and reduce fat around the heart in 44 obese adults with type 2 diabetes. Participants received the drug BYETTA along with metformin. Researchers used MRI scans to measure heart …

This study tested a combination of two chemotherapy drugs (BCNU and TMZ) given before radiation therapy in 53 people newly diagnosed with a rare type of brain cancer called anaplastic oligodendroglioma. The goal was to see how well the drugs shrank tumors and to learn more about …

This pilot study tested a non-invasive brain stimulation technique called tDCS in 17 people with drug-resistant epilepsy. The stimulation was personalized using prior brain recordings to target the exact area causing seizures. The goal was to see if this approach could safely red…

This early-stage trial tested a new injection for wrist osteoarthritis that combines the patient's own fat (microfat) and platelet-rich plasma (PRP). The goal was to see if this mixture is safe and can reduce pain and improve wrist function, potentially delaying the need for surg…

This study looked at whether it is safe to reduce or narrow antibiotics once doctors know which germ is causing a severe infection (sepsis). 120 intensive care patients were randomly assigned to either continue their original broad antibiotics or switch to a more targeted treatme…

This study tested whether continuously monitoring central venous oxygen saturation (ScvO2) during major abdominal surgery helps doctors give fluids more precisely, reducing complications. 220 patients over 50 with moderate-to-high surgical risk were randomly assigned to ScvO2-gui…

This study looked at whether people with lupus-related kidney inflammation (lupus nephritis) who have been stable for two years can safely stop taking immunosuppressive drugs like mycophenolate mofetil or azathioprine. One hundred patients were split into two groups: one continue…

This study tested whether a special type of MRI that measures sodium levels in the brain can help locate the exact area causing seizures in people with drug-resistant epilepsy. 78 patients who were already scheduled for epilepsy surgery received a sodium MRI scan. Researchers com…

This study looked at whether a blood test called the basophil activation test (BAT) can accurately diagnose food allergies in children, potentially replacing the need for oral food challenges (OFCs). Researchers tested 116 children aged 0-18 who were already scheduled for an OFC.…

This study tested whether a 50% nitrous oxide (laughing gas) and oxygen mixture can reduce pain during a legal abortion done with local anesthesia. 71 adults took part. The main goal was to measure pain during the procedure, with follow-up pain checks and side effects recorded. T…

This study compares two methods of giving a nerve block to control pain after lung surgery (thoracotomy). One method uses ultrasound to guide the needle, the other uses a camera inside the chest during minimally invasive surgery. The goal is to see which approach reduces the need…

This study tested a new, minimally invasive procedure for people with grade II or III hemorrhoids. Instead of surgery, doctors used tiny coils to block the main artery supplying blood to the hemorrhoids, aiming to shrink them and reduce pain. The study included 26 participants an…

This study tested whether a special gas system called Airseal® can reduce pain after laparoscopic hysterectomy compared to the standard system. 80 women having the surgery for non-cancer reasons were randomly assigned to one of the two systems. The main goal was to measure pain l…

This study tested whether regularly doing a set of gentle stretching poses (Stretching Postural®) could help pregnant women with new lower back pain. Sixty women with low-risk pregnancies were split into two groups: one received standard advice plus the stretching routine, the ot…

This study tested whether special video games controlled by muscle signals (EMG) can improve walking in children with cerebral palsy. Thirty children aged 2 to 10 with mild to moderate CP played these games alongside physical therapy. The goal was to help them better control ankl…

This study tested a personalized exercise program for children aged 5 to 17 with advanced cancer that cannot be cured. The program included walking on a treadmill and muscle-strengthening exercises, with the goal of seeing if it is safe and tolerable. Only 4 children took part, a…

This study looked at whether giving a low dose of ketamine continuously could lower the amount of strong painkillers (opioids) needed by people with serious injuries. The goal was to see at least a 25% reduction in opioid use over 48 hours while still controlling pain just as wel…

This study tested whether using virtual reality (VR) exposure therapy could prevent anxiety, depression, and PTSD in people recovering from a lung transplant in the ICU. 62 adults on the lung transplant waiting list participated. They used a VR headset to gradually get used to st…

This study looked at how patients and healthcare professionals experienced a new way of organizing primary care, where different health workers work together as a team. Researchers interviewed 48 patients and staff at one health centre in France. The goal was to understand what w…

This study looked at 11 people with a repaired heart condition called tetralogy of Fallot who needed a new pulmonary valve. Researchers used MRI scans to measure heart muscle stiffness (fibrosis) and how well the heart pumped during rest and exercise. The goal was to see if these…

This completed study looked at how certain immune cells (T cells and NK cells) might damage blood vessels in people with systemic sclerosis, a rare autoimmune disease. Researchers analyzed blood samples from 30 participants to measure a protein called Fractalkine and study cell i…

This study looked at 44 preterm infants born before 28 weeks to see if their brain activity and general movements could predict cerebral palsy. Researchers used EEG and movement recordings to find patterns linked to the condition. The goal was to improve early diagnosis and help …

This study looked at how weak electric currents applied to the scalp can change brain activity in people with drug-resistant focal epilepsy. Researchers used special brain recordings to measure spikes and connections between brain regions during and right after stimulation. The g…

This study looked at a rare disease called IgG4-related disease, which causes swelling and scarring in organs. Researchers compared immune cells in the blood of 75 people: those with the disease, those with Sjogren syndrome, and healthy volunteers. The goal was to better understa…

This study uses computer models to simulate brain activity in 20 epilepsy patients. The goal is to better interpret EEG and MEG signals to locate where seizures start. Researchers hope this will lead to a tool that helps surgeons remove the right brain tissue to stop seizures.

This study looked at antibodies in the intestines of 160 people: 80 with Crohn's disease, 40 with ulcerative colitis, and 40 without inflammatory bowel disease. Researchers took blood samples and intestinal biopsies to compare antibody levels in the gut versus the blood. The goal…

This study looked at how brain circuits in people with Parkinson's disease produce abnormal electrical rhythms. Researchers measured these rhythms in 23 patients with implanted brain electrodes. The goal was to understand why these patterns occur, which could lead to better treat…

This study looked at 55 very premature babies (born at 28-30 weeks) to see if natural mother's milk or pasteurized milk better helps their guts mature. Researchers measured bioactive molecules in the milk and tracked gut development during small feedings. The goal was to understa…

This study looks at how certain genes behave in people with major depression compared to healthy individuals. Researchers collected blood samples from 30 participants to measure the activity of 21 specific genes. The goal is to better understand how depression changes over time a…

This study looked at 60 epilepsy patients who already had electrodes implanted in their brains. Researchers recorded brain activity at the same time using scalp sensors and the implants. The goal was to see how well non-invasive methods can detect the same brain signals as the im…

This study looked at 124 people with septic shock to see if the difference in carbon dioxide levels between veins and arteries could predict their recovery. Researchers monitored patients closely for three days and tracked organ failure and survival at 28 days. The goal was to fi…

This study looked at whether advanced MRI scans and a nerve test called MUNIX can detect the earliest signs of nerve damage in people who carry a gene mutation for familial amyloid neuropathy. Researchers studied 60 adults with the TTR mutation, comparing those with and without s…

This study looked at blood samples from 24 people with axial spondyloarthritis (a type of inflammatory arthritis) and 12 healthy volunteers to understand how a receptor called KIR3DL2 contributes to inflammation. Researchers also tested whether a drug called IPH4102 could reduce …

This study tested a special auditory training program (MPAA) in 22 deaf children aged 4 to 10 who have cochlear implants. The program uses different sounds like speech and music to improve skills such as identifying and remembering sounds. The goal was to see if the training help…

This study looked at how Hirschsprung disease, a rare birth defect affecting the bowel, impacts brain development and quality of life in children aged 8 to 13. Researchers tested thinking skills and surveyed families to understand long-term effects after surgery. The goal was to …

This study looked at whether certain cells and substances in the blood can help predict if a person who has had a heart attack or unstable angina will have another heart problem within a year. Researchers took blood samples from 180 patients and tracked their health for one year.…

This study looked at whether lying face down (prone position) while awake can improve how air moves through the lungs in COVID-19 patients with breathing failure. Twenty adults with COVID-19 and low oxygen levels were monitored using a special imaging technique (EIT) to measure l…

This completed study looked at 262 people with dilated cardiomyopathy, a condition where the heart muscle is weakened and enlarged. Researchers used a special MRI technique (T1 mapping) to measure scarring (fibrosis) in the heart. They wanted to see if the amount of scarring coul…

This study looked at how the numbing drug lidocaine behaves in the body when given as a special type of local anesthesia for mastectomy. Researchers took blood samples from 6 women over 48 hours to measure lidocaine levels. The goal was to better understand the drug's safety and …

This study checked if certain blood markers can predict serious heart events like heart attack or death within a year after a stent procedure. Researchers measured two types of cells related to blood vessel health in 170 adults scheduled for a stent. The goal was to see if these …

This study tested a new type of brain sensor that is cheaper and easier to use than current ones. Researchers compared it to standard sensors in 4 people with epilepsy to see if it could detect abnormal brain activity. The goal is to make advanced brain imaging more widely availa…

This study compares two blood-filtering techniques—plasma exchange and immunoadsorption—in 40 patients with severe kidney failure caused by ANCA vasculitis or Goodpasture disease. The goal is to see which method removes disease-causing antibodies more quickly. Results may help do…

This study measured how often muscle loss (sarcopenia) happens in men aged 70 and older with prostate cancer who are treated with radiation and hormone therapy. Researchers screened 112 patients using a simple questionnaire and body scans. The goal was to understand risk factors …

This study tested whether advanced MRI scans can find new biomarkers for amyotrophic lateral sclerosis (ALS), a fast-progressing nerve disease. Researchers used high-field and very-high-field MRI to look at the brain, spinal cord, and muscles of 22 ALS patients over six months. T…

This study used a very powerful 7 Tesla MRI to look for tiny brain changes in 15 people with idiopathic REM sleep behavior disorder (iRBD) compared to 15 healthy volunteers. iRBD is a sleep condition that often leads to Parkinson's disease years later. The goal was to find early …

This completed study from a French hospital looked at long-term after-effects in 56 adults who had severe malaria. Researchers used a questionnaire to check for physical, thinking, and emotional problems one year after diagnosis. The goal is to better understand and track these l…

This completed study aimed to create a biobank of 'organoids'—tiny, 3D mini-tumors grown from liver cancer tissue. Researchers collected samples from 48 patients with colorectal cancer that spread to the liver or with primary liver cancer. The goal was to see if they could reliab…

This study involved 50 women and used a new, fast 3D MRI method to watch how pelvic organs move. The goal was to better understand pelvic floor disorders, which affect many women's quality of life. The approach combined high-resolution MRI with dynamic imaging to create 3D models…

This study looked at tiny particles called microparticles in the blood of 41 people with colorectal cancer that had spread to the lining of the abdomen. The goal was to see if these particles could serve as a better way to detect this spread early, compared to current tests. Rese…

This study looked at why antibiotics often fail to treat pneumonia in COVID-19 patients on ventilators. Researchers measured how much of the antibiotic piperacillin reaches the lungs in 34 adults with severe COVID-19 pneumonia. The goal was to understand if poor lung penetration …

This completed study used chest MRI scans to look at blood flow in the lungs of 30 people with COPD. The goal was to learn how blood vessels adapt during exercise and how this relates to disease progression. By better understanding these changes, researchers hope to improve care …

This study aims to develop a more objective way to measure lupus disease activity using a blood test that analyzes gene activity. Researchers will compare this gene-based score with standard clinical assessments in 80 lupus patients. The goal is to create a non-invasive tool to b…

This study looked at how lupus, a chronic autoimmune disease, affects the emotional and social lives of 160 patients and their spouses. Researchers used interviews and questionnaires to understand the couple's experience, beliefs about the disease, and quality of life. The goal i…