Assistance Publique Hopitaux De Marseille

This trial tests whether reducing the dialysate flow rate during hemodialysis from the standard 500 mL/min to 400 mL/min can maintain adequate blood cleansing while cutting water use. About 250 adults on chronic hemodialysis will each try both flow rates for one month. The main g…

This trial asks whether adults with ulcerative colitis who are in deep remission can safely stop taking their JAK inhibitor medication (tofacitinib, upadacitinib, or filgotinib) instead of continuing daily maintenance therapy. Half of the 224 participants will stop treatment and …

This study tests a non-invasive brain training technique called neurofeedback for people with drug-resistant epilepsy. Participants learn to change their own brain activity to reduce seizures. The study compares real neurofeedback to a sham (fake) version to see if it truly works…

This trial tests whether a new ultra-rapid genetic test, using third-generation sequencing, can diagnose familial lymphohistiocytosis (FHL) in children within 5 days instead of the usual 6-8 weeks. FHL is a rare, life-threatening genetic condition where the immune system attacks …

This study tests whether a specific antibody in the blood, called anti-CD146, can help doctors diagnose lung diseases caused by breathing in silica dust at work. Silica exposure can lead to serious lung problems like scarring, inflammation, and cancer, but there is currently no s…

This study tests a near-infrared spectroscopy device that scans the liver with light to diagnose and measure fatty liver disease. Researchers aim to see if it can accurately detect fat levels above 5% and 30%, which are important for liver transplant decisions. The study will inc…

This study aims to develop an artificial intelligence system that can automatically detect potential melanomas using 3D whole-body skin images. Researchers will collect scans from 1,000 adults with many moles and compare the AI's findings to those of three skin specialists. The g…

This trial tests whether a self-administered vaginal swab, analyzed with advanced molecular technology, can detect and treat bacterial imbalances early in pregnancy. Pregnant women at high risk of preterm birth will either receive this screening plus targeted antibiotics or stand…

This study will test whether a coordinated care model, including a care coordinator and a health mediator, can prevent sexual violence among 675 female asylum seekers in France. Participants will be randomly assigned to either this coordinated care or usual care. The main goal is…

This study tests whether a spinal cord stimulator can reduce chronic nerve pain caused by chemotherapy. 68 adults with pain lasting over a year will have the device implanted and then randomly receive either active or sham stimulation. The goal is to see if active stimulation pro…

This study tests a slow-release melatonin (PedPRM) in 120 children aged 6 to 18 who have anorexia nervosa and trouble sleeping. Participants take either melatonin or a placebo for 13 weeks. The goal is to see if it safely improves total sleep time and related symptoms like anxiet…

This study asks whether a simple questionnaire, called SSPedi, can capture the symptoms that children with brain or spinal cord tumors experience while on new cancer therapies. Children aged 2 to 18 who are already part of a larger French study (SACHA) will use an app to report t…

This study asks whether post-traumatic stress disorder (PTSD) influences how well epilepsy surgery works. Researchers will follow 42 adults with drug-resistant focal epilepsy for two years after surgery, comparing seizure freedom and quality of life between those with and without…

This study aims to better understand changes in the mouth's tiny organisms (dysbiosis) in people over 60 or with weakened immune systems. Researchers will collect dental plaque and saliva samples from 250 participants to see how common these changes are and whether a simple saliv…

This study checks if physiotherapists get chemotherapy drugs inside their bodies after treating patients who recently received these drugs. Twenty physiotherapists will provide urine and skin samples before and after giving massages or other hands-on care. The goal is to understa…

This study will collect blood and swab samples from 160 adults with solid tumors who are about to start immunotherapy. The goal is to find a biological 'signature' that can predict which patients will develop severe immune-related side effects. If such a signature is found, it co…

This study follows 75 young adults with severe hemophilia who were part of an earlier study as teens. Researchers want to see if their healthcare habits change as they become adults and what factors help them stick to treatment. The goal is to understand how to support a smooth t…

This study looks at 50 adults with primary central nervous system lymphoma who are receiving high-dose methotrexate, a key chemotherapy. The goal is to see if measuring the drug early in the blood can predict later kidney problems. By identifying at-risk patients sooner, doctors …

This study looks at how Gamma Knife radiosurgery affects brain connections in people with severe facial pain called trigeminal neuralgia. About 28 adults will get brain scans before treatment and at 1, 3, and 12 months after. The goal is to see if changes in brain wiring match pa…

This study aims to create better MRI methods for looking at the brains of people with multiple sclerosis (MS). Researchers will test these methods on 272 healthy volunteers and MS patients using both standard (3 Tesla) and ultra-high-field (7 Tesla) MRI machines. The goal is to m…

This study aims to develop a simple blood test that checks how well a person's immune cells can fight blood cancer. Researchers will collect blood samples from 166 adults with blood cancers to measure immune cell activity and look at genetic factors. The goal is to create a test …

This study will follow 100 people who need a stoma (an opening in the belly to pass stool) after surgery. Some will have their stoma site marked and get education before surgery, while others will not. The goal is to see if these steps improve quality of life and reduce problems …

This study looks at whether teenagers with severe scoliosis have trouble sensing where their body is in space (proprioception). Researchers will compare brain scans and muscle measurements of 60 teens with scoliosis to healthy controls. The goal is to understand if these issues a…

This study will examine tissue and blood samples from 105 adults having lung surgery to understand why some people with chronic lung disease develop pulmonary hypertension (high blood pressure in the lungs). Researchers will compare three groups: those with lung disease and pulmo…