TYPE 1 DIABETES (T1D)

This study compares the iLet Bionic Pancreas, an automated insulin delivery system, to usual care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the device or continue their routine care for 13 weeks to see if it improves blood sugar co…

This study tests an experimental drug, CIR-0602K, in 40 adults with type 1 diabetes who already use an automated insulin pump. The goal is to see if the drug helps keep blood sugar in a healthy range longer and lowers the amount of insulin needed each day. Participants will recei…

This study looks at whether a community health worker (CHW) can help Black children with type 1 diabetes better manage their blood sugar using automated insulin pumps. Sixteen children and their families will meet with a CHW coach for six months, then be followed for another six …

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells enclosed in a protective capsule, for people with unstable type 1 diabetes who still experience dangerous low blood sugar episodes despite using an automated insulin pump and continuous glucos…

This study tests whether a very low-calorie ketogenic diet (600-800 calories per day) can help 14 adults with type 1 diabetes and obesity lose weight safely while using an automated insulin pump. Participants follow a structured 4-week meal replacement program under close medical…

This study watches how the Twiist insulin pump works in everyday life for people with type 1 diabetes. It includes about 1,875 adults and children aged 6 and older who already use the pump. Researchers will track serious low blood sugar events, diabetic ketoacidosis, and any hosp…

This early-stage study tests a new cell therapy called GNTI-122 in 16 adults recently diagnosed with type 1 diabetes. The therapy is made from the participant's own blood cells and aims to help the body better manage blood sugar by preserving insulin-making cells. The main goal i…

This study looks at whether using ultrasound to detect fatty lumps (called lipohypertrophy or 'Lipos') caused by insulin injections can help people with diabetes improve their blood sugar control. About 50 adults with type 1 or type 2 diabetes who use insulin and a continuous glu…

This study looks at whether automated insulin delivery (AID) systems can safely manage blood sugar during labor and delivery for pregnant people with type 1 diabetes. Researchers will compare AID to standard IV insulin in 150 participants. The goal is to improve newborn blood sug…

This study is for adults with type 1 diabetes who already use an automated insulin delivery system. Researchers want to see if adding a weekly injection of tirzepatide (a drug that helps control blood sugar and weight) can improve glucose levels even more. About 42 people will ta…

This study looks at whether a finger-prick blood test done at home can replace the standard oral glucose tolerance test (OGTT) for diagnosing type 1 and type 2 diabetes in children and young people. The standard test requires a vein drip and multiple blood draws over hours, which…

This study tests a mindfulness app called Calm Health in 10 young adults (ages 18-30) with type 1 diabetes. Participants use the app and get feedback linking their mindfulness, blood sugar, stress, and sleep. The goal is to see if the app is usable and helps reduce diabetes-relat…

This study is testing a virtual peer support program for 300 people in Canada living with type 1 diabetes (or their caregivers). Participants join small online groups based on shared experiences (like age, parenting, or cultural background) and attend monthly meetings and webinar…

This study tests a mobile app that gives personalized tips and insights based on blood sugar, exercise, mood, and sleep patterns. The goal is to help 60 adults aged 30-65 with type 1 diabetes or similar conditions exercise more often and safely. All participation is remote, so yo…

This study aims to identify people at increased risk of developing type 1 diabetes by testing for specific markers in the blood called autoantibodies. Researchers are recruiting 30,000 children and adults aged 1 to 45 who have a family member or close friend diagnosed with type 1…

This study looks at how exercising in hot conditions (40°C) affects blood sugar levels in people with type 1 diabetes compared to a normal temperature (20°C). Thirty-eight adults with type 1 diabetes who exercise regularly will do 40 minutes of moderate exercise in both temperatu…

This study looks at how obstructive sleep apnea (pauses in breathing during sleep) affects blood sugar levels in adults with type 1 diabetes. Researchers will monitor 40 participants' glucose patterns using continuous glucose monitors. The goal is to understand if sleep apnea mak…

This study looks at how blood sugar levels change during exercise in healthy adults and those with type 1 diabetes. Researchers want to see if these changes are similar each time a person exercises. Participants will cycle or rest after a standard breakfast, and their glucose wil…

This study aims to better understand acute kidney injury and chronic kidney disease by analyzing kidney tissue from 1,000 volunteers. Researchers will use advanced technology to identify different disease subtypes and find new targets for therapies. The goal is to pave the way fo…

This study looks at whether a continuous glucose monitor (CGM) can detect early loss of function in transplanted pancreatic islets for people with type 1 diabetes. About 36 adults who have already received an islet transplant will wear a CGM for one year. The goal is to see if a …

This study looks at whether sexual activity increases the risk of low blood sugar (hypoglycemia) in adults with type 1 or type 2 diabetes who use insulin and a continuous glucose monitor (CGM). One hundred participants will mark their sexual activity in a CGM app for 3 months, an…