TYPE 1 DIABETES (T1D)

This study tests a new automated insulin delivery system (NMX8) in 230 adults with type 1 diabetes who are not meeting their blood sugar goals. Participants will use either the NMX8 system or another approved system to compare how well they keep blood sugar in a healthy range. Th…

This study looks at 14 people with type 1 diabetes who use the MiniMed 780G insulin pump. They will do a supervised strength training session twice, once with the pump in SmartGuard mode and once with a temporary target setting. The goal is to see which setting keeps blood sugar …

This study tests whether wearing a continuous ketone monitor alongside a continuous glucose monitor can reduce the risk of a serious side effect (high ketones) from the drug sotagliflozin in people with type 1 diabetes. About 52 adults will take two different doses of the drug wh…

This study tests a smartphone app called DailyDose that gives personalized advice on insulin and carbs during exercise or low blood sugar. Researchers want to see if using the app helps adults with type 1 diabetes lower their blood sugar levels over 24 weeks. About 99 people who …

This study tests a mobile app called Diactive-1 that gives children and teens with type 1 diabetes personalized resistance training and education. The app uses a simple handgrip strength test to create a custom exercise plan. The goal is to help young patients better manage their…

This study tests a new medicine called IMC-S118AI in people with type 1 diabetes. The main goal is to see if it is safe and how the body processes it. Researchers will also check if it can help preserve the cells that make insulin. About 154 adults with a specific genetic type (H…

This study tests a new microneedle patch that measures ketones and glucose continuously in people with type 1 diabetes. Ten participants will wear the patch while their insulin pump is paused for three hours. The goal is to see if the patch readings match standard blood tests.

This study tests whether a single-session depression intervention can help teens with type 1 diabetes improve their mood and blood sugar control. About 80 youth aged 11-18 with mild depression will either receive the intervention or standard education. Researchers will track mood…

This study tests a three-part training program for older adults (65+) with diabetes who use insulin. The program teaches CGM technology, data skills, and lifestyle adjustments to improve glucose monitoring and reduce diabetes-related distress. 150 participants will be compared to…

This study tests a decision-support toolkit that helps adults with type 1 diabetes prepare for moderate exercise by suggesting timing, insulin adjustments, and carb intake. Twenty participants will try three different pre-exercise guidance methods, including the toolkit, during s…

This study will test whether a new e-learning app can help school nurses learn more about diabetes devices like insulin pumps and continuous glucose monitors. About 86 school nurses in Pennsylvania will use the app over 16 weeks and complete surveys before and after. The goal is …

This study looks at how the timing of insulin doses before meals affects where fat is stored in people with type 1 diabetes. Ten adults with type 1 diabetes will have their fat storage measured after different insulin timings. The goal is to understand if delaying or skipping ins…

This study will see if it's practical to screen close family members (parents, siblings, or children) of people with type 1 diabetes for early signs of the disease. About 1,000 adults in Quebec will give blood samples and answer questions. If they test positive for certain antibo…

This study follows 300 children and adults who have antibodies linked to type 1 diabetes but no symptoms yet. Over up to 10 years, researchers will track how their blood sugar and immune markers change. The goal is to better predict who will develop diabetes and to reduce severe …