SUBSTANCE USE DISORDERS
Clinical trials for SUBSTANCE USE DISORDERS explained in plain language.
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New tablet screening program aims to uncover hidden struggles in HIV patients
Disease control CompletedThis study tested a new program in HIV clinics to better identify and treat substance use, depression, and anxiety. Over 10,000 HIV-positive adults used tablets to screen for these issues during routine visits. Those who screened positive could then receive counseling from a beha…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Apr 01, 2026 14:43 UTC
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Can online therapy and a buddy system help beat addiction?
Disease control CompletedThis study tested whether an online cognitive behavioral therapy (CBT) program, with or without one-on-one peer support, helps people reduce their substance use. It involved 198 adults already receiving standard addiction treatment. Researchers compared three groups over eight we…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Can a trauma therapy break the cycle of addiction?
Disease control CompletedThis study tested whether EMDR therapy, a treatment often used for trauma, could help people with substance use disorders who also have a history of psychological trauma. Researchers worked with 64 participants who were not actively using drugs to see if the therapy could reduce …
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: Hospital Clinic of Barcelona • Aim: Disease control
Last updated Apr 01, 2026 14:40 UTC
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New therapy aims to tame emotions, curb cravings in addiction recovery
Disease control CompletedThis study tested a new therapy program designed to help adults in residential rehab for drug or alcohol problems. The goal was to teach them skills to better handle difficult emotions, tolerate distress, and reduce cravings. 36 participants received either the new weekly therapy…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: Lauro Gutiérrez Castro • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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New program aims to keep patients on track after hospital discharge
Disease control CompletedThis study tested a new support program designed to help people with both bipolar disorder and a substance use problem stay on their treatment plan after leaving the hospital. Researchers compared a specialized counseling program against a standard safety check-in program, both a…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: Butler Hospital • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Skills training boosts confidence to stay sober, study finds
Disease control CompletedThis small study tested whether teaching life skills like problem-solving, communication, and stress management could help men with substance use disorders feel more confident in their ability to stay sober. Researchers worked with 45 men in a Cairo hospital who had relapsed befo…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: Ain Shams University • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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Virtual reality aims to rewire the brain for recovery
Disease control CompletedThis early-stage study tested whether a special virtual reality (VR) program could help people in early recovery from opioid use disorder. The VR experience was designed to help participants think more positively about their future, with the goal of reducing opioid use and increa…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: EARLY_PHASE1 • Sponsor: Indiana University • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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Mindfulness shows promise in small addiction study, but relapses still occur
Disease control CompletedThis small, completed study looked at whether an 8-week mindfulness and meditation program could help people with substance use disorders stay in recovery. Three adults participated in weekly sessions and daily practice to learn stress management and coping skills. While all part…
Matched conditions: SUBSTANCE USE DISORDERS
Sponsor: Bout Me Healing • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Can better parenting be the key to helping teens beat addiction?
Disease control CompletedThis study aimed to improve treatment for teens with substance use disorders by figuring out what makes treatment work best. Researchers tested whether focusing more intensely on teaching parents better management skills could lead to better outcomes for their teens. They compare…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: Oregon Social Learning Center • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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NY tests coaching program to fight opioid crisis in clinics
Disease control CompletedThis study tested whether coaching addiction treatment clinics could help more patients start and stay on medications for opioid use disorder and remain in care longer. Researchers worked with 30 clinics in New York, providing training on data-driven management and patient-center…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: NYU Langone Health • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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New program aims to bridge healthcare gap for people leaving prison
Disease control CompletedThis study tested a new support program designed to help people with HIV, hepatitis C, or substance use disorders get medical care after they are released from prison. Researchers worked with 219 men and women before their release to see if the program was practical and acceptabl…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: University of Wisconsin, Madison • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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New program aims to help veterans stay on track after mental health crisis
Disease control CompletedThis study tested a new support program designed to help veterans who have both bipolar disorder and a substance use problem after they leave the hospital. It compared a special counseling program against a basic safety check-in program, both added to their regular care. The goal…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Mar 23, 2026 15:18 UTC
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App aims to help those with HIV and addiction stick to treatment
Disease control CompletedThis study tested a new support program for people living with HIV who also use drugs like opioids or stimulants. The program combined a phone app for medication reminders with therapy sessions focused on managing emotions and communication. Researchers wanted to see if this appr…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Mar 23, 2026 15:18 UTC
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Ingestible sensor sends alerts to your phone to boost medication adherence
Disease control CompletedThis study tested a new system to help people who use substances take their daily HIV prevention pill (PrEP) more consistently. Participants used a special 'digital pill' that sends a signal when swallowed, paired with a smartphone app that provided reminders and support. The goa…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: PHASE3 • Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated Mar 23, 2026 15:17 UTC
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New telehealth program aims to help families navigate dual challenges of psychosis and substance use
Disease control CompletedThis study tested a family training program delivered by video call. It aimed to help family members support a relative who is experiencing early psychosis and using substances like alcohol or cannabis. The goal was to see if the program improved family wellbeing and helped the r…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: Mclean Hospital • Aim: Disease control
Last updated Mar 23, 2026 15:15 UTC
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Breaking down shame: new therapy aims to keep men with HIV in care
Disease control CompletedThis study tested a counseling program designed to help men who have sex with men (MSM) and who are living with HIV and substance use stay engaged in their HIV care. The program focused on helping participants manage difficult emotions like shame and stigma related to HIV, sexual…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Mar 23, 2026 15:14 UTC
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Can a wearable device curb cravings? new tech tested for addiction
Disease control CompletedThis study tested a new, portable version of a breathing exercise technique called heart rate variability biofeedback (HRVB) for people recovering from substance use disorders. The goal was to see if using a small wearable device to guide breathing in the moment could help people…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Mar 10, 2026 12:53 UTC
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ERs test peer coaches to fight overdose crisis
Disease control CompletedThis study tested whether connecting people with substance use disorders to a peer recovery coach during an emergency room visit helps them get support. It compared in-person coaching, video call coaching, and just giving out a resource list. The goal was to see if coaching helps…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: Emory University • Aim: Disease control
Last updated Mar 04, 2026 15:30 UTC
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Can a smartphone app help prevent HIV after jail release?
Prevention CompletedThis study tested whether a smartphone app called GeoPassport, combined with peer mentor support and small rewards, could help men and transgender women leaving jail access important health services. The goal was to see if this approach helped people get HIV prevention medication…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: University of California, Los Angeles • Aim: Prevention
Last updated Mar 30, 2026 14:34 UTC
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HIV prevention pills delivered on wheels to High-Risk communities
Prevention CompletedThis study tested whether providing HIV prevention medication (PrEP) immediately at a needle exchange program helps people stay HIV-negative. Researchers enrolled 90 adults who use the syringe service and tested negative for HIV. They measured if getting the medicine right at the…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: PHASE4 • Sponsor: University of Miami • Aim: Prevention
Last updated Mar 23, 2026 15:15 UTC
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Can writing help heal Veterans' trauma and addiction?
Symptom relief CompletedThis study tested if adding a brief writing therapy to a standard 28-day residential addiction program could help Veterans who have both PTSD and a substance use disorder. 56 Veterans were randomly assigned to receive either the standard program alone or the standard program plus…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Apr 01, 2026 14:42 UTC
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Phone calls aim to ease Veterans' pain and reduce substance risks
Symptom relief CompletedThis study tested whether a phone counseling program could help veterans with chronic pain and risky substance use. Over 1100 post-9/11 veterans applying for service-related compensation were randomly assigned to receive either the counseling calls or usual care. The counseling a…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: Yale University • Aim: Symptom relief
Last updated Apr 01, 2026 14:42 UTC
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VA tests virtual therapy to combat loneliness and addiction in veterans
Symptom relief CompletedThis study tested a new telehealth therapy program designed to help Veterans who feel lonely and struggle with substance use. Researchers wanted to see if a therapy focused on reducing loneliness could also help people use substances less often. They worked with 36 Veterans to se…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Apr 01, 2026 14:40 UTC
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Pandemic's hidden toll: study reveals mental health crisis among nursing home workers
Knowledge-focused CompletedThis study aimed to understand how the COVID-19 pandemic affected the mental health of nursing home staff in France. Researchers surveyed 501 workers to measure rates of post-traumatic stress, depression, and burnout. The goal was to document the psychological impact of working t…
Matched conditions: SUBSTANCE USE DISORDERS
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Apr 01, 2026 22:56 UTC
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Scientists search for genetic clues to addiction
Knowledge-focused CompletedThis study aimed to understand how genes might be linked to substance use disorders and related behaviors. Researchers collected genetic information and measured thinking skills, emotions, and decision-making in 847 adults, including healthy volunteers and people with substance u…
Matched conditions: SUBSTANCE USE DISORDERS
Sponsor: National Institute on Drug Abuse (NIDA) • Aim: Knowledge-focused
Last updated Apr 01, 2026 22:56 UTC
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Researchers test ways to fight stigma in HIV care
Knowledge-focused CompletedThis project aimed to plan and test ideas for reducing stigma against people who use drugs in clinics that provide HIV prevention and care. Researchers worked with 51 healthcare workers from community health centers. They developed and tested a training program and explored poten…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: Wayne State University • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Researchers seek community input to fix racial gap in addiction trials
Knowledge-focused CompletedThis study aimed to gather feedback from Black individuals to create a practical guidebook for researchers. The goal is to improve how clinical trials for substance use disorders recruit and keep Black participants, who are often underrepresented. The researchers worked with 65 p…
Matched conditions: SUBSTANCE USE DISORDERS
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:12 UTC
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Researchers check if depression test works for people battling addiction
Knowledge-focused CompletedThis study checked if a questionnaire designed to measure depression works well for people being treated for substance use disorders. Researchers had 289 participants in treatment fill out the questionnaire. They analyzed the answers to see if the questionnaire is reliable and me…
Matched conditions: SUBSTANCE USE DISORDERS
Sponsor: Lauro Gutiérrez Castro • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:34 UTC
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First human test of experimental drug for meth addiction begins
Knowledge-focused CompletedThis early-stage study tested the safety of an experimental drug called CS-1103 in healthy volunteers. Researchers gave 32 participants single, increasing doses through an IV to see how their bodies handled the drug and to check for side effects. The goal is to gather basic safet…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: PHASE1 • Sponsor: Clear Scientific, Inc. • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:28 UTC
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Can clinic rules plus training break down barriers to addiction care?
Knowledge-focused CompletedThis small pilot study tested whether adding a clinic-wide policy change to standard staff training could better reduce stigma and improve care for people with substance use disorders in mental health clinics. Researchers compared two clinics: one where providers only received tr…
Matched conditions: SUBSTANCE USE DISORDERS
Phase: NA • Sponsor: Wayne State University • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:38 UTC