SUBSTANCE USE DISORDERS

This study tests a community-based approach to screen and treat hepatitis C in people who use drugs across four French cities. Around 3,400 participants will be tested and offered treatment, with the goal of curing the infection. The program also looks at mental health and addict…

This study tests a personalized program for low-income adults aged 35-64 who face higher risks of heart disease, heavy drinking, and HIV. The program includes patient outreach, individual health benefits, and help with healthcare costs. Researchers will measure changes in alcohol…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION versus working with a Peer Specialist. Researchers will track which approach leads to better treatment engagement, less substance use, and imp…

This study tests a program that combines two types of therapy to help mothers recovering from substance use disorders and their young children (up to age 5). The goal is to improve the parent-child relationship, reduce stress, and keep children safe and out of foster care. About …

This study looks at two different approaches to help community hospitals start treating opioid use disorder. Researchers want to see which method works better at getting patients to continue treatment within 34 days after leaving the hospital. The study involves 24 hospitals and …

This study tests whether having a peer case manager helps people with HIV who also have mental health or substance use problems get the care they need. About 405 participants will be randomly assigned to usual care or to work with a peer who supports them in finding treatment. Th…

This study tests a program called the Bridge Model to help 250 people (16+) who are homeless or have low income quit smoking and other substances. Participants get support with jobs, housing, and social connections, not just medical treatment. The goal is to improve quality of li…

This study tests whether a special team that treats both severe infections and substance use disorders together can help hospitalized patients who inject drugs. About 480 adults will either get this integrated care or usual treatment. The goal is to see if the team approach lower…

This study tests whether remote programs (via Zoom, FaceTime, or phone) can help people manage their alcohol use and improve well-being. About 300 adults with alcohol use disorder will be randomly assigned to either a telehealth group program or enhanced usual care. The goal is t…

This study tests a clinic-supported mobile health program called Connections for up to 806 HIV patients who also have substance use disorders. Participants get support from their care team and peer mentors for one year to help them stay virally suppressed and attend appointments.…

This study looks at whether a therapy called RRFT, which treats both substance use and PTSD together, works better than standard separate treatments for teens aged 13-18. About 212 teens with trauma history and both conditions will be randomly assigned to RRFT or usual care. Rese…

This study tests a type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks and then put on a performance. Researchers…

This study follows 120 people in group therapy for alcohol use disorder to see which patient traits predict success. Researchers will track factors like mental health, drinking severity, personality disorders, and cognitive issues to find out who completes treatment and stays sob…

This study looks at whether a text-message screening program for mental health and substance use issues helps more pregnant and postpartum women get the treatment they need compared to standard in-person screening. Over 10,000 women from MUSC clinics will participate by completin…

This study looks at how people react to stress in a pretend emergency room. Researchers will have 20 people who use meth and 10 healthy adults do public speaking and math tasks. They want to see if this setup feels like a real ER and measure stress through saliva, blood pressure,…

This study was designed to see if a type of brain training called neurofeedback could improve brain activity and thinking skills in people whose main drug is cocaine. The study was withdrawn before any participants were enrolled, so no results are available. It was planned for ad…

This study tests a new way to screen for substance use disorders in people with HIV using an online patient portal, instead of only during clinic visits. The goal is to make screening easier and more accessible, especially for those who may face barriers. About 900 adults with HI…

This study aimed to see if a non-invasive brain stimulation technique called cTBS could reduce cravings in people recovering from methamphetamine use disorder. Researchers planned to enroll 40 adults living in a residential treatment program and use brain scans to measure changes…

This study looks at different methods to help primary care clinics better screen patients for substance use disorders. Researchers will compare approaches like practice coaching, group learning, and financial rewards. The goal is to find the best way to increase screening rates a…

This study looked at whether combining patient questionnaires, staff training, and telemedicine could help people with HIV get better care for mental health and substance use issues. It was designed for adults receiving HIV care at five clinics in Alabama. The study was withdrawn…

This study aimed to understand how a person's socioeconomic status (like income and education) influences their recovery from substance use disorder. Researchers planned to track participants' social standing, decision-making, and quality of life over time. However, the study was…

This study looks at how well a smartphone app works to help primary care clinics screen for and treat substance use disorders. About 60 adults who already have a primary care provider at Mayo Clinic will use the app to connect with care. The goal is to understand what helps or ge…