SUBSTANCE USE DISORDERS

This study tests whether a virtual reality experience, where people see an avatar that looks like them in a park, can help those in early recovery from stimulant use reduce drug use and stay abstinent longer. Researchers will compare this VR experience to a plain VR park without …

This study tests a mobile app called Connections for people living with HIV who also have substance use disorders. The app provides resources, weekly check-ins, discussion rooms, and private messaging with peer mentors and care teams. Researchers want to see if using the app help…

This study tests a program called Minds and Mentors that combines mindfulness training with peer support to help people stick with their medication for opioid use disorder. About 240 adults currently on medication like methadone or buprenorphine will be randomly assigned to eithe…

This study looks at whether a therapy called RRFT, which treats substance use and PTSD together, works better than standard separate treatments for teens aged 13-18. About 212 teens with both conditions will be randomly assigned to RRFT or usual care, and tracked for a year. The …

This study looks at two different approaches to help community hospitals start treating opioid use disorder in patients. One approach is basic training and education, while the other adds extra support like practice facilitation. The goal is to see which method works better at ge…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION that provides counseling, peer support, and community outreach for 6 months, versus just linking them with a peer specialist. Researchers hope…

This study tests whether a personalized program—including patient navigation, individual health benefits, and financial help—can reduce deaths from preventable causes like heart attacks, strokes, heavy drinking, and HIV in low-income adults aged 35–64. Researchers will track chan…

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This study tests a program called the Bridge Model that provides social support, volunteering, and job opportunities to help people with nicotine or substance use disorders who are homeless or low-income. Researchers want to see if this approach improves quality of life and helps…

This study tests whether a special care team that combines treatment for severe injection-related infections and substance use disorders can improve outcomes. 480 hospitalized adults who inject drugs will either receive this integrated care or usual treatment. The main goal is to…

This study tests a therapy program called MIO-CPP for mothers recovering from substance use disorders and their young children (up to age 5). The program combines individual therapy for mothers and joint mother-child sessions to strengthen their bond and improve child well-being.…

This study aims to eliminate hepatitis C among people who use drugs in Paris, Marseille, Lyon, and Fort-de-France. Researchers will screen participants, provide immediate treatment, and use a peer-referral system to reach more people. The goal is to see if this community-based ap…

This trial tests a school-based program called PreVenture, which uses brief workshops tailored to teens' personality traits to prevent substance use disorders. Over 12,500 students across Canada are taking part. The goal is to see if this approach can delay or reduce drug and alc…

This study compares a text message-based mental health and substance use screening program (Listening to Women & Pregnant and Postpartum People) to standard in-person screening. Over 10,000 pregnant and postpartum people will participate. The goal is to see if the text-based appr…

This pilot study tests a specific type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks, then put on a performance.…

This study from Mayo Clinic tests whether a smartphone app called Senyo Health can help connect people with substance use disorders to treatment through their primary care doctor. Sixty participants will use the app for 12 weeks, which includes therapy modules, weekly check-ins w…

This study tests whether telehealth programs can help people manage their alcohol use and improve well-being. About 300 adults with alcohol use disorder will join remotely via video or phone. They will be split into two groups: one gets a telehealth program, the other gets usual …

This study looks at whether counseling sessions done over video call (telehealth) are practical and well-liked by people with substance use disorder who are not currently getting treatment. About 50 participants will try the program and share their feedback through surveys. The g…

This study aimed to understand how a person's socioeconomic status (like income and education) affects their recovery from substance use disorder. Researchers planned to follow adults in early recovery for up to 3 years, measuring changes in social functioning, quality of life, a…

This study looks at how to help primary care clinics screen more adults for substance use problems. It compares different support strategies like coaching, team learning, and financial rewards. 144 clinic staff from 48 practices will take part. The goal is to find the best way to…

This study tests a new program to make it easier for people living with HIV to get screened for substance use disorders. The program uses online patient portals and in-clinic tools to find those who need help and connect them to treatment. Researchers will track how many people g…

This study aimed to see if adding patient questionnaires, staff training, and telemedicine could improve mental health and substance use disorder care for people living with HIV. It was planned for five clinics in Alabama, but the trial was withdrawn before enrolling any particip…

This study aimed to see if a non-invasive brain stimulation technique called TMS could help people with methamphetamine use disorder control their cravings. Researchers planned to recruit 40 adults living in a residential treatment program and give some real stimulation and other…

This study looks at how people's bodies react to stress in a pretend emergency room. Researchers will have 30 adults (20 who use meth and 10 healthy volunteers) do public speaking and math tasks while measuring stress hormones, heart rate, and blood pressure. The goal is to see i…

This study aimed to see if a brain training method called ZQLN could improve brain activity and thinking skills in people with cocaine use disorder. It planned to enroll adults aged 21 to 51 who had completed detox. However, the study was withdrawn before any participants were en…

This study follows 120 people in group therapy for alcohol use disorder to see which patient factors—like mental health, drinking severity, personality, or thinking skills—predict who finishes treatment and stays sober a year later. Researchers hope to learn how to match patients…