SUBSTANCE USE DISORDERS

This study is testing whether a single dose of psilocybin (the active compound in 'magic mushrooms'), given alongside supportive psychotherapy, is safe and can help reduce symptoms of depression and substance use. It will involve 50 veterans and first responders who have not resp…

This study is testing whether a prescription sleep medicine called daridorexant can help people quit smoking. Researchers want to see if improving sleep quality and daytime alertness during the first three weeks of quitting makes it easier to stay smoke-free. The study will invol…

This pilot study is testing a new peer-led support program called Yuva Sath. It aims to help young people in India who inject drugs stay engaged in their treatment and use HIV prevention services. Researchers will compare 60 participants who receive the program to those who do no…

This study is testing whether a new mobile app is practical and acceptable for people currently in treatment for opioid or stimulant addiction. The app uses videos and games to teach users how substance use affects brain functions like attention and decision-making. Researchers w…

This study aims to see if people recovering from mental health or substance use problems, when trained, can effectively help others with depression and addiction. It will test a talk-based therapy called Behavioral Activation, delivered by these 'peer recovery specialists', in 25…

This study is testing whether a special music therapy app, used alongside standard addiction treatment, can help adults with trauma histories better manage their emotions, anxiety, and stress. About 100 adults in residential treatment for substance use will use the app for a week…

This study is testing whether a small, wearable device that gently stimulates nerves in the ear can help people with alcohol use disorder get through detox. Participants will wear the device for five days while staying at a clinic to see if it reduces withdrawal symptoms, craving…

This study is testing whether a technology-based program is useful and acceptable for people living in supportive housing who have substance use challenges. It will involve about 25 participants who will use the program, which includes videos and incentives, for two weeks. The ma…

This study aims to understand if recent federal policy changes made it easier for veterans to get and stay in treatment for opioid addiction. Researchers will compare health records from before and after the policy changes for over 185,000 veterans with opioid or alcohol use diso…

This study aims to understand how temporarily stopping and then restarting tirzepatide—a medication that helps control blood sugar and appetite—affects brain activity, mood, hunger, and daily life. Researchers will follow 40 adults currently taking tirzepatide, measuring changes …

This early-stage study aims to understand the safety and effects of common recreational drugs on people who have used opioids like heroin or oxycodone in the past. Researchers will enroll 50 healthy adults with a history of recreational opioid use to measure how these substances …