SOLID TUMORS
Clinical trials for SOLID TUMORS explained in plain language.
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New mRNA vaccine takes on solid tumors in early trial
Disease control OngoingThis early-phase study tests an experimental mRNA cancer vaccine (mRNA-4157) in 161 people with solid tumors. The vaccine is designed to train the immune system to attack cancer cells. Some participants receive the vaccine alone, while others get it with the immunotherapy drug pe…
Matched conditions: SOLID TUMORS
Phase: PHASE1 • Sponsor: ModernaTX, Inc. • Aim: Disease control
Last updated Apr 29, 2026 01:36 UTC
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New combo therapy tackles tough cancers in early trial
Disease control OngoingThis early-stage trial tests a new cell treatment (GK01) combined with an immunotherapy drug (PD-1 antibody) in 15 people with advanced solid tumors that have spread or come back. The main goal is to see if the combination is safe and to measure how the body processes it. Researc…
Matched conditions: SOLID TUMORS
Phase: PHASE1 • Sponsor: Tianjin Medical University Cancer Institute and Hospital • Aim: Disease control
Last updated Apr 29, 2026 01:36 UTC
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Can a cancer drug wipe out hidden tumor cells after surgery?
Disease control OngoingThis study tests the safety and effectiveness of the drug pembrolizumab in preventing cancer from returning. It includes 17 adults with MSI-H solid tumors who had surgery but still have tumor DNA in their blood. Participants receive pembrolizumab or a placebo for up to 12 months,…
Matched conditions: SOLID TUMORS
Phase: EARLY_PHASE1 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Apr 29, 2026 01:36 UTC
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New hope for kids with Hard-to-Treat cancers: entrectinib trial opens
Disease control OngoingThis study tests an experimental drug called entrectinib in children and teens with advanced solid tumors or brain cancers that have come back or not responded to other treatments. The goal is to find the safest dose and see if the drug can shrink tumors, especially in those with…
Matched conditions: SOLID TUMORS
Phase: PHASE1, PHASE2 • Sponsor: Hoffmann-La Roche • Aim: Disease control
Last updated Apr 29, 2026 01:36 UTC
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Experimental immune therapy combo targets Hard-to-Treat cancers
Disease control OngoingThis early-stage trial tests an experimental drug called IMP321, which aims to boost the immune system's ability to fight cancer. It is given alongside standard treatments like chemotherapy or immunotherapy to people with advanced solid tumors that have spread. The main goal is t…
Matched conditions: SOLID TUMORS
Phase: PHASE1 • Sponsor: Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest • Aim: Disease control
Last updated Apr 29, 2026 01:34 UTC
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New combo targets tough cancers with DNA flaws
Disease control OngoingThis study tests whether combining two drugs, olaparib and pembrolizumab, can shrink or control advanced solid tumors that have specific DNA repair defects. About 300 adults whose cancer has not responded to standard treatments will receive the combination. The goal is to see how…
Matched conditions: SOLID TUMORS
Phase: PHASE2 • Sponsor: Merck Sharp & Dohme LLC • Aim: Disease control
Last updated Apr 28, 2026 13:02 UTC