New drug combo targets Hard-to-Treat cancers in early trial
NCT ID NCT04418167
First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 26 times
Summary
This early-stage study tests a new drug, JSI-1187, alone or with another drug (dabrafenib) in people with advanced solid tumors that have certain gene changes (MAPK pathway mutations). The main goal is to check safety and find the right dose. About 71 adults with tumors that have not responded to standard treatments will take part.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Massachusetts General Hospital Cancer Center
Boston, Massachusetts, 02114, United States
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Mayo Clinic Cancer Center
Phoenix, Arizona, 85054, United States
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Mayo Clinic Cancer Center
Jacksonville, Florida, 32224, United States
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Mayo Clinic Cancer Center
Rochester, Minnesota, 55905, United States
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University of Arizona Comprehensive Cancer Center
Tucson, Arizona, 85724, United States
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University of California Helen Diller Family Comprehensive Cancer Center
San Francisco, California, 94158, United States
Conditions
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