PRIMARY SCLEROSING CHOLANGITIS

This study tests whether a fecal microbiota transplant (FMT) can improve liver health in people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease. About 58 adults will receive either FMT or a placebo. The main goal is to see if FMT lowers a key liver enzyme…

This early study tests whether siplizumab can safely prevent the immune system from attacking a new liver in people with autoimmune hepatitis or primary sclerosing cholangitis. Eight participants will receive two doses of the drug around the time of transplant and be monitored fo…

This study tests whether the drug BRS201 (hydroxocobalamin) can improve liver health in people with primary sclerosing cholangitis (PSC), a chronic bile duct disease. About 28 adults with PSC will take the drug or a placebo for 4 weeks each, in random order. The main goal is to s…

This study tests a drug called elafibranor in 350 adults with primary sclerosing cholangitis (PSC), a rare disease that scars the bile ducts and can lead to liver failure. Participants will take either elafibranor or a placebo daily for several years to see if the drug delays dis…

This early-stage study tests whether the drug TAK-781 is safe and tolerable. First, healthy volunteers receive either the drug or a placebo. Then, people with primary sclerosing cholangitis (PSC) receive the drug. The study also looks at how the body processes TAK-781. About 134 …

This study is for 143 adults with primary sclerosing cholangitis (PSC), a rare chronic liver disease. Researchers want to understand what causes PSC by collecting blood, saliva, urine, stool, and tissue samples, along with imaging and surveys. Participants will undergo procedures…

This study looks at how statins, a common cholesterol medicine, change bile acids and gut bacteria in people with primary sclerosing cholangitis (PSC), a rare liver disease with no cure. Researchers will collect samples from 15 adults with PSC to understand the disease better. Th…

This study looks at gut bacteria in 3,000 adults with chronic liver diseases like autoimmune hepatitis and fatty liver. Researchers want to find which bacteria are linked to each disease and how they affect disease progression. Participants provide stool samples for analysis, but…

This study creates a collection of blood, urine, stool, and other samples from up to 9,150 people with cholestatic liver diseases like primary biliary cholangitis and primary sclerosing cholangitis. The samples and health data will be used by researchers to better understand thes…

This study follows 1,000 children with primary sclerosing cholangitis (PSC), a rare liver disease that damages bile ducts. Researchers will collect medical data, DNA, and other samples to understand how PSC progresses and affects daily life. The goal is to identify factors that m…

This research study collects bile, bile duct brushings, and medical information from people with Primary Sclerosing Cholangitis (PSC) and healthy volunteers. The goal is to learn more about changes in the liver that may lead to disease. No treatments or drugs are tested.