Could a form of vitamin B12 help control a rare liver disease?
NCT ID NCT05835505
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial tests whether the drug BRS201 (a form of vitamin B12) can improve liver health in people with primary sclerosing cholangitis (PSC), a rare liver disease. Over 8 weeks, 28 participants will take either the drug or a placebo for 4 weeks each, in random order. The main goal is to see if BRS201 lowers a key liver enzyme called alkaline phosphatase, which is often high in PSC.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
BRS201 (hydroxocobalamin, a form of vitamin B12)
What this could lead to
If it works, this could point toward a treatment to control liver damage in primary sclerosing cholangitis by lowering key liver enzyme levels.
What could go wrong
This is a small, early Phase 2 trial with only 28 people. It tests a short-term effect on a lab marker, not long-term outcomes, so results may not lead to a proven treatment.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Brigham and Women's Hospital
RECRUITINGChestnut Hill, Massachusetts, 02467, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••