POSTPARTUM DEPRESSION

This study tested a new capsule called MI078 in 72 women with postpartum depression. The women took the drug or a placebo for 3 days. Researchers measured depression scores to see if the drug helps symptoms and to find the best dose. The trial is complete, and results will show i…

This study looked at whether adding supervised Pilates exercises and structured prenatal education to standard care could reduce depressive symptoms, low back pain, and labor pain in first-time mothers. 85 pregnant women participated, with some attending the program and others re…

This study tested a single injection of RE104 in 84 women with moderate-to-severe postpartum depression. The goal was to see if it reduces depressive symptoms better than a low-dose comparison. Results will help determine if this approach is safe and effective for new mothers.

This study looked at three ways to manage pain after severe perineal tears (called OASIS) that can happen during vaginal delivery. Sixty-seven women received either a placebo, epidural morphine alone, or epidural morphine plus intravenous ketamine. The goal was to see which optio…

This study tested whether an 8-week mindfulness-based cognitive therapy (MBCT) program can reduce stress, anxiety, and depression in pregnant women at risk for psychological distress. 84 women participated, with some receiving MBCT and others getting usual care. The goal was to u…

This study tested a psychoeducational program based on the Watson Human Caring Model to reduce depressive symptoms and strengthen mother-infant bonding after childbirth. 88 pregnant women participated. The program covered topics like postpartum depression, baby care, and bonding.…

This study tested a non-drug treatment called Personalized Integrated Chronotherapy (PIC) for depression during pregnancy and after childbirth. 120 pregnant women with major depression were randomly assigned to receive either usual care (medication or therapy) or PIC plus usual c…

This study tested whether a 12-session parenting group therapy, called the Connecting and Reflecting Experience (CARE) program, is helpful and doable for new parents struggling with postpartum depression or anxiety. Seventeen parents of babies aged 3 to 12 months took part. The g…

This study tested a program called the Pregnant Moms' Empowerment Program (PMEP) for pregnant women who had experienced intimate partner violence in the past year. The goal was to see if the program could improve mothers' mental health, reduce the chance of further violence, and …

This study tested an experimental oral drug called NORA520 in 93 women with severe postpartum depression. Participants took the drug or a placebo for just 3 days. Researchers measured how well it reduced depressive symptoms, checked for side effects, and looked at how much of the…

This study tested an experimental drug called SAGE-547 (brexanolone) given as a 60-hour intravenous infusion to 138 women with severe or moderate postpartum depression. The goal was to see if it could quickly reduce depressive symptoms compared to a placebo. Results showed that t…

This study tested a drug called SAGE-547, given as an IV infusion over 60 hours, to see if it could reduce symptoms of postpartum depression in women. 108 women with moderate to severe depression after childbirth took part. The goal was to measure changes in depression scores com…

This study tested whether the drug ZULRESSO (brexanolone) can be safely given to women with postpartum depression in their own homes instead of a hospital. Fifty-two women took part. The main goal was to see if any side effects caused the infusion to be stopped or interrupted. Th…

This early study tested an experimental drug called SAGE-547 in 4 women with severe postpartum depression. The main goal was to check safety and how the drug works in the body, not to prove it treats depression. Because it was very small and had no comparison group, the results a…

This study screens women who gave birth in four French hospitals for postpartum depression and anxiety during the COVID-19 pandemic. Participants fill out three questionnaires shortly after delivery and again about a month later. The goal is to measure how common postpartum depre…

This study looked at whether the natural bacteria in your gut are linked to mood changes after having a baby, including postpartum depression. Researchers collected samples from 30 pregnant women before and after delivery to see if certain gut bacteria patterns relate to emotiona…

This study tested a free chatbot called Rosie that gives pregnant women and new moms instant, reliable health information from trusted sources. 400 minority women who were pregnant or had an infant under 6 months used the chatbot to ask questions and get answers. The goal was to …

This study tested a simple program to help new mothers who are at higher risk for health problems after giving birth. 220 Black mothers who delivered at the Hospital of the University of Pennsylvania took part. Some received a helpful pamphlet and a patient navigator they could c…

This study tested whether adding psychodramatic role-playing to standard childbirth classes could reduce postpartum depression and improve self-confidence and social support in first-time mothers. 57 pregnant women participated, with one group taking regular classes and the other…

This study followed 300 pregnant women to understand why some develop mood disorders like depression or bipolar episodes after giving birth. Researchers collected genetic, hormonal, and environmental data to find patterns that could predict these episodes. The goal is to better i…

This study enrolled 74 women with a history of postpartum depression to see if the sudden drop in hormones after childbirth causes mood symptoms. Researchers used hormone medications to simulate pregnancy and delivery in a controlled setting. The goal was to understand whether it…

This study tested whether a single virtual group session could help Spanish-speaking mothers learn about postpartum depression and available resources. Twenty-six mothers of infants under 2 months old participated. The session included a video testimonial, discussion of symptoms,…