PERITONEAL CARCINOMATOSIS

This study tests whether giving a weight-based dose of heated chemotherapy during surgery is as effective but less toxic than a standard flat dose. About 100 people with advanced gastrointestinal cancer that has spread to the lining of the abdomen will take part. The goal is to f…

This study is for people with stomach cancer that has spread to the lining of the abdomen. It compares standard chemotherapy given through a vein to the same treatment plus an extra chemotherapy drug (paclitaxel) delivered directly into the belly through a small port. The goal is…

This study compares two methods of delivering chemotherapy directly into the abdomen for people whose cancer has spread there. One method uses heated chemotherapy during surgery (HIPEC), while the other sprays it as a mist during a minimally invasive procedure (PIPAC). The goal i…

This study tests whether adding a special chemotherapy spray (PIPAC) directly into the abdomen during standard treatment can help women with advanced ovarian cancer. About 160 women aged 18-75 will be randomly assigned to get either standard chemo plus one PIPAC or standard chemo…

This early-phase trial tests a new treatment for people with a type of stomach or esophagus cancer that has spread to the lining of the abdomen. The therapy uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The cells are given …

This study tests a single injection of Radspherin®, a radioactive treatment given directly into the abdomen, for people with advanced ovarian, fallopian tube, or primary peritoneal cancer that has spread to the lining of the belly. About 114 participants will receive either stand…

This early-stage study is testing a new method called PIPAC, which turns chemotherapy into a fine mist and sprays it directly into the abdomen during a keyhole surgery. The goal is to see if this approach is safe and can reduce side effects compared to standard chemotherapy. Abou…

This study tests a simple breathing technique called cardiac coherence to help reduce anxiety in people awaiting surgery for peritoneal cancer. About 60 participants will practice guided breathing sessions before their operation. The goal is to see if this easy, drug-free method …

This study is testing whether a special recovery plan helps patients with cancer that has spread to the abdominal lining get out of the hospital sooner after major surgery. About 300 patients at 20 Italian hospitals will follow either the usual recovery process or a new, structur…

This early-phase study tests whether a special dye called pafolacianine (CYTALUX) can make cancer cells glow during surgery for gastrointestinal cancers that have spread inside the abdomen. About 10 adults will receive the dye before surgery, and surgeons will use a special camer…

This study looks at whether giving heated chemotherapy directly into the abdomen during keyhole surgery can increase PD-L1 levels in stomach cancer that has spread to the lining of the belly. PD-L1 is a protein that helps the immune system recognize cancer cells. The goal is to s…

This study is looking at new blood tests to see if they can detect tiny bits of cancer left behind after surgery for colorectal cancer that has spread to the abdomen (peritoneal metastases). Currently, doctors rely on a visual check during surgery, but this may miss small amounts…

This study aims to see if lab-grown tumor models can predict how well heated chemotherapy (HIPEC) works during surgery for cancers that have spread to the abdomen. About 60 adults whose tumors cannot be fully removed safely will take part. Researchers will compare tumor responses…