Heated vs. sprayed chemo: which works better for belly cancer?

NCT ID NCT07282834

Recruiting now Disease control Sponsor: Patrick Wagner, MD, FACS Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two methods of giving chemotherapy directly into the abdomen for people whose cancer has spread there (peritoneal carcinomatosis). One method, HIPEC, uses heated chemotherapy circulated during surgery. The other, PIPAC, delivers chemotherapy as a pressurized spray during a minimally invasive procedure. The trial will enroll 200 adults to see which approach is safer, better tolerated, and more effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mitomycin C (chemotherapy)
What this could lead to: If successful, this trial could identify which direct-to-abdomen chemotherapy method is safer and more tolerable for patients with cancer spread in the belly.
What could go wrong: This is a mid-stage trial with 200 participants, so results may not apply to all patients. Both methods involve chemotherapy side effects and surgical risks.

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Conditions

The condition(s) this trial relates to.

digestive system cancer neoplasm Neoplasm Metastasis peritoneal carcinomatosis peritoneal neoplasm peritoneum cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ABDOMINAL CANCER ABDOMINAL CANCER PATIENTS PERITONEAL (METASTATIC) CANCER PERITONEAL CARCINOMATOSIS

Contacts and locations

Locations

Allegheny Health Network West Penn Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States

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