Heated chemo showdown: one dose fits all or custom fit?

NCT ID NCT04779554

Recruiting now Disease control Sponsor: Prakash Pandalai Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests two ways of giving heated chemotherapy directly into the abdomen during surgery for advanced gastrointestinal cancers that have spread to the lining of the belly. One method uses a fixed dose for everyone, while the other adjusts the dose based on the patient's body size. The goal is to see if the weight-based approach leads to less chemotherapy entering the bloodstream, which could mean fewer side effects. About 100 people will take part in this randomized phase 2 trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mitomycin C (chemotherapy)
What this could lead to: If successful, this could show that weight-based dosing of heated chemotherapy is safer with fewer side effects, while still controlling the cancer.
What could go wrong: This is a phase 2 trial with only 100 people, so results are preliminary. It focuses on drug levels in the blood, not long-term survival or cure. The approach may not work for all patients.

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Conditions

The condition(s) this trial relates to.

appendiceal neoplasm colorectal neoplasm peritoneal carcinomatosis peritoneal neoplasm pseudomyxoma peritonei

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERITONEAL CARCINOMATOSIS

Contacts and locations

Locations

University of Kentucky
RECRUITING

Lexington, Kentucky, 40536, United States
University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States

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