PERIODONTAL DISEASES

This study compares a new surgical technique for treating advanced gum disease to the standard approach. The new method uses a single small cut to preserve blood supply and keep granulation tissue—which helps healing—in place. About 50 adults with deep gum pockets that didn't ful…

This study looks at whether using a toothpaste with sodium bicarbonate (baking soda) and fluoride can help maintain gum health in adults who have already had non-surgical gum disease treatment. One hundred participants will use either the special toothpaste or a placebo for six m…

This study looks at whether vitamin D levels and supplements can reduce inflammation in people with gum disease (periodontitis or gingivitis). Researchers will measure markers of inflammation in blood and gum fluid before and after treatment. The study involves 120 adults with di…

This study tests whether a collagen sponge can help regrow bone around teeth damaged by gum disease, compared to a standard bone-graft material. About 80 adults with advanced gum disease and deep pockets will receive one of the two treatments during surgery. The main goal is to s…

This study tests whether adding a substance made from your own blood (injectable platelet-rich fibrin) to a standard bone graft helps repair bone damage caused by gum disease. Sixteen adults with advanced periodontitis will receive either the combination treatment or the graft al…

This study compares three different surgical methods to treat gum disease (periodontitis). The goal is to see which technique best reduces deep gum pockets and helps gums reattach to teeth. About 60 adults with gum disease will be randomly assigned to one of the three procedures.…

This study tests whether adding a special gel (rhPDGF, L-PRF, or EMD) to standard deep-cleaning helps repair bone damage from gum disease better than cleaning alone. 88 adults with advanced gum disease and bone pockets will be randomly assigned to one of four groups. Researchers …

This study tests whether a special laser (FX-405) can improve the treatment of gum disease when used along with standard deep cleaning (scaling and root planing). About 70 adults with moderate to severe gum disease will receive the laser treatment or a placebo. The main goal is t…

This study tests whether a gel containing lovastatin, placed under the gum after deep cleaning, can improve gum health more than cleaning alone. It includes 44 adults with gum disease, both smokers and non-smokers. Each person gets the medicated gel on one tooth and a placebo gel…

This study tests whether a special dental gel, used at home, can improve gum health more than standard care alone in people with moderate to severe gum disease (periodontitis). About 76 adults will use the gel after a deep cleaning and be followed for 6 months. The main goal is t…

This study tests if a telehealth program can help cancer survivors prevent mouth sores, gum disease, and tooth decay. About 100 adult cancer survivors who finished treatment at least 6 months ago will either get the telehealth program or usual care. The goal is to see if the prog…

This study is testing whether a new online questionnaire can accurately assess a person's risk for gum disease (periodontitis or gingivitis). About 393 adults in Saudi Arabia will fill out the questionnaire and then have a dental exam to compare results. The goal is to create a r…

This study looks at two types of stitches used after gum surgery to see if they help gums heal equally well. About 84 adults having gum surgery will get one of the two stitch materials. Researchers will check healing, pain, and patient satisfaction about 10 days after surgery.

This study tests whether using a microscope during gum surgery helps the gums heal better than using standard dental loupes (magnifying glasses). About 25 adults with gum disease will take part. Researchers will check early wound healing and compare how long the stitching takes w…

This study looks at whether training medical staff and using electronic health records can encourage older adults (55+) on Medicaid to visit the dentist more often. About 929 participants from 12 primary care clinics will be split into two groups: one where doctors get extra trai…

This study looks at how the severity of pemphigus vulgaris, a chronic autoimmune skin disease, relates to gum health. Researchers will measure mouth sores and blood markers in 20 adults with the condition and compare them to standard gum measurements. The goal is to understand ho…

This study looks at how the edge of a clear aligner at the gumline affects bacteria in the gum groove. 39 people in the final phase of orthodontic treatment will wear aligners with two different edge designs—one covering 2 mm of gum, the other following the gumline exactly. Resea…

This observational study looks at whether a specific immune pathway (JAK1/2) is overactive in people with gum disease (periodontitis) compared to those with healthy gums. Researchers will collect small gum tissue samples from 30 adults to measure pathway activity. The goal is to …

This study looks at whether certain markers in blood and saliva can help predict how well people with gum disease (gingivitis or periodontitis) will heal after standard non-surgical treatment. About 180 adults will provide samples and have their gums measured before and 3 months …

This study looks at how people's oral hygiene habits and gum health (like gingivitis or periodontitis) affect their quality of life. About 160 adults will have their gums examined and fill out a questionnaire about how their mouth feels day-to-day. The goal is to better understan…

This study looks at two types of gum tissue from people with severe gum disease to see how they affect healing after treatment. Researchers will compare samples from smokers and non-smokers to understand if smoking changes the tissue's ability to heal or fight infection. The goal…

This study looks at how antibiotics like amoxicillin and metronidazole work in the body when used with deep cleaning for severe gum disease. Researchers want to find the best dose and treatment length (3 vs 7 days) to kill harmful bacteria without overusing antibiotics. About 45 …

This study checks how often Candida albicans, a common fungus, is found in Syrian adults with gum disease (periodontitis). Researchers will collect samples from 100 patients to see if the fungus is linked to more severe gum problems. The goal is to better understand what role Can…