METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Clinical trials for METASTATIC MALIGNANT NEOPLASM IN THE BRAIN explained in plain language.
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Early trial aims to boost Radiation's power against brain tumors
Disease control OngoingThis early-stage study is testing a new drug called berzosertib, given alongside standard whole-brain radiation therapy. The main goal is to find the safest and most effective dose of the drug combination for patients whose lung cancer has spread to the brain. Researchers hope th…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 01, 2026 23:11 UTC
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Brain cancer trial tests precision radiation to protect memory
Disease control OngoingThis study compares two types of radiation therapy for patients with 4 to 15 brain metastases from cancers other than melanoma. One method targets tumors precisely with a single high dose, while the other treats the entire brain with lower doses over two weeks. Researchers want t…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE3 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Precision radiation zaps brain tumors, aims to spare memory
Disease control OngoingThis study is testing a highly focused, single-dose radiation treatment for people with melanoma that has spread to more than three spots in the brain. The main goals are to see if this treatment can control the brain tumors and, importantly, if it causes less memory and thinking…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Apr 01, 2026 14:40 UTC
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Scientists test pill to supercharge radiation against brain cancer
Disease control OngoingThis early-stage study is testing a new oral drug called IPdR (ropidoxuridine) in combination with standard whole-brain radiation therapy. The goal is to see if the drug makes cancer cells in the brain more sensitive to radiation, potentially improving treatment for patients whos…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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Three-Drug attack on Tough-to-Treat skin cancer
Disease control OngoingThis study is testing two different combinations of three drugs to see if they are safe and effective for people with advanced melanoma that has a specific genetic change (BRAF mutation) and has spread or cannot be removed by surgery. The goal is to control the cancer by using an…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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New brain cancer fight: can a second drug boost lung cancer treatment?
Disease control OngoingThis study is testing if adding a drug called bevacizumab to a standard lung cancer drug (osimertinib) works better to control cancer that has spread to the brain. It is for adults with a specific type of advanced lung cancer (EGFR-positive non-small cell lung cancer) who have no…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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Genetic testing guides brain cancer fight
Disease control TerminatedThis study tests whether using genetic testing to match patients with specific drugs can help control cancer that has spread to the brain. It is for adults with solid tumors (like lung or breast cancer) that have spread to the brain and have certain genetic changes. Patients rece…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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New drug duo enters first human trial for Tough-to-Treat lung cancer
Disease control OngoingThis is an early-stage trial testing a combination of two oral drugs, sapanisertib and telaglenastat, for patients with advanced non-small cell lung cancer that has spread and progressed after standard treatments. The main goals are to find the safest dose of the drug combination…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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Early trial aims to boost Radiation's power against brain tumors
Disease control OngoingThis early-stage study is testing whether adding a drug called trametinib to standard whole-brain radiation therapy is safe and effective for treating cancer that has spread to the brain. The main goals are to find the safest dose of the drug and to see how much of it reaches the…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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New combo attack on lung cancer brain tumors
Disease control OngoingThis study is testing whether combining immunotherapy drugs with targeted radiation to the brain works better to control advanced lung cancer that has spread there. It aims to find the safest and most effective doses of the drugs nivolumab and ipilimumab when given with two diffe…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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New combo attack on deadly melanoma brain tumors
Disease control OngoingThis study is testing whether combining the drugs Avastin and Tencentriq, with or without a third drug called Cotellic, can help control melanoma that has spread to the brain. It is for adults with this specific type of advanced skin cancer who have not yet received treatment for…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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Precision brain radiation study aims to spare thinking skills in cancer patients
Disease control OngoingThis study tests whether a precise form of radiation called stereotactic radiosurgery (SRS) can control lung cancer that has spread to the brain while better preserving patients' memory and thinking abilities. It compares SRS, which targets only the tumors, to standard whole-brai…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 25, 2026 14:07 UTC
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Zapping the spot: can a quick radiation blast after brain surgery stop Cancer's return?
Disease control OngoingThis study is testing if a single, highly focused dose of radiation to the area where a brain tumor was removed works better than just watching and waiting. It aims to see if this targeted treatment can prevent the cancer from growing back in the same spot for at least six months…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE3 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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Brain tumor timing trial: does radiation before surgery work better?
Disease control OngoingThis study compares two treatment schedules for patients with cancer that has spread to the brain. All patients receive surgery and a precise, high-dose radiation treatment called stereotactic radiosurgery (SRS). The trial is testing whether giving the radiation treatment before …
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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Brain cancer radiation showdown: one big zap vs. several small ones
Disease control OngoingThis study compares two ways of delivering targeted radiation after surgery to remove cancer that has spread to the brain. It tests whether giving one high-dose treatment is as good as, or worse than, giving several smaller doses over a few days. The goal is to see which method b…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Mar 09, 2026 14:24 UTC
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Couples meditation program aims to ease brain cancer burden
Symptom relief OngoingThis study is testing an online meditation and breathing program designed for couples where one person has a brain tumor. The goal is to see if the program is practical and helps improve spiritual well-being, sleep, mood, and overall quality of life for both the patient and their…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Apr 01, 2026 14:41 UTC
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Can early brain care protect quality of life during cancer treatment?
Symptom relief OngoingThis study tests whether early neuropsychological evaluation and support helps patients with brain metastases maintain their quality of life and thinking abilities after radiation therapy. Researchers are comparing two groups: one receiving specialized neuropsychological care alo…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief
Last updated Mar 23, 2026 15:18 UTC
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Brain mapping test aims to protect movement during cancer radiation
Knowledge-focused OngoingThis study is testing a non-invasive brain mapping tool called nTMS to see if it helps doctors plan radiation treatment for brain tumors more safely. It involves 22 adults who have already had radiation for tumors near the brain's movement control area. The goal is to see if this…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:28 UTC