METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Clinical trials for METASTATIC MALIGNANT NEOPLASM IN THE BRAIN explained in plain language.
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Could a zap of radiation after brain surgery keep cancer away?
Disease control OngoingThis study tests whether a precise type of radiation called stereotactic radiosurgery, given after surgery to remove brain tumors, can prevent the tumors from coming back. About 132 people with up to 3 brain metastases will either receive this radiation or be observed. The goal i…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE3 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 17, 2026 04:35 UTC
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Zapping brain tumors without harming memory: new hope for advanced melanoma
Disease control OngoingThis study looks at whether a focused radiation treatment called stereotactic radiosurgery (SRS) can control melanoma that has spread to more than 3 areas in the brain while also protecting memory and thinking skills. About 49 adults with advanced melanoma and multiple brain tumo…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 17, 2026 04:34 UTC
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Gene-Tailored drugs aim to shrink brain tumors in new trial
Disease control OngoingThis study tests whether genetic testing can help doctors choose the right drug for people whose cancer has spread to the brain. About 50 adults with solid tumors that have certain gene changes (like NTRK, ROS1, or KRAS) will receive a targeted pill. The goal is to see if these d…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated May 17, 2026 04:32 UTC
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New drug duo targets hard-to-treat lung cancer
Disease control OngoingThis early-phase trial tests two experimental drugs, sapanisertib and telaglenastat, in people with advanced non-small cell lung cancer that has spread to the brain or other areas. The main goals are to find the safest dose and see if the combination can shrink tumors or slow the…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 17, 2026 04:30 UTC
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New drug cocktail shows promise for deadly brain tumors in melanoma patients
Disease control OngoingThis study tests whether combining two or three drugs can shrink or control melanoma that has spread to the brain. The drugs work by blocking tumor growth and helping the immune system attack cancer cells. The trial involves 29 adults with untreated brain metastases and aims to s…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 17, 2026 04:29 UTC
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Triple-Drug attack shows promise for Tough-to-Treat melanoma
Disease control OngoingThis study tests two different three-drug combinations in people with advanced melanoma that has spread or can't be removed by surgery. The drugs include immunotherapy (nivolumab) plus targeted therapies that block cancer growth signals. The goal is to see if these combinations w…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 17, 2026 04:29 UTC
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Experimental combo targets Hard-to-Treat esophageal cancer
Disease control OngoingThis early-stage trial tested a drug called adavosertib combined with radiation for people with advanced esophageal or stomach cancer that cannot be removed by surgery. The goal was to find the safest dose and see how well the combination works. Only 4 people took part, so result…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 17, 2026 04:17 UTC
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New combo therapy targets lung cancer brain spread in early trial
Disease control OngoingThis early-phase trial tests a drug called berzosertib combined with whole brain radiation for people with lung cancer that has spread to the brain. The main goal is to find the safest dose and see what side effects occur. About 15 adults with non-small cell, small cell, or neuro…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 17, 2026 04:15 UTC
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Immunotherapy and radiation team up against lung cancer brain tumors
Disease control OngoingThis study is for people with advanced non-small cell lung cancer that has spread to the brain. It tests whether adding immunotherapy drugs (nivolumab, with or without ipilimumab) to radiation therapy can better control the cancer. The goal is to find the safest dose and see if i…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 15, 2026 11:56 UTC
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New drug shows promise for breast cancer brain tumors
Disease control OngoingThis study tests a drug called sacituzumab govitecan in 44 people with HER2-negative breast cancer that has spread to the brain. The drug works like a smart bomb, attaching to cancer cells and delivering chemotherapy directly to them. The goal is to see if it can shrink brain tum…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated May 15, 2026 11:55 UTC
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New study aims to find better radiation option for brain metastases
Disease control OngoingThis study compares two radiation treatments for people whose cancer has spread to the brain (but not from melanoma). One is stereotactic radiosurgery, which targets tumors precisely with a high dose. The other is whole brain radiation, which treats the entire brain with lower do…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE3 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 14, 2026 12:05 UTC
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One big dose or several small ones? new study tests best radiation for brain metastases
Disease control OngoingThis study looks at two ways to give radiation after surgery for cancer that has spread to the brain. One method uses a single, strong dose of radiation, while the other uses several smaller doses over time. The goal is to see which approach better prevents the tumor from coming …
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated May 13, 2026 16:00 UTC
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Engineered immune cells target brain tumors in early trial
Disease control OngoingThis early-phase study tests a new treatment called HER2-CAR T cells for people with HER2-positive cancers that have spread to the brain or its lining. The treatment involves taking the patient's own immune cells, modifying them to recognize and attack HER2-positive cancer cells,…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 11, 2026 20:47 UTC
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Timing of brain radiation could change outcomes for cancer patients
Disease control OngoingThis study tests whether giving focused radiation before surgery for brain metastases works better than the usual approach of radiation after surgery. About 237 adults with 1 to 4 brain tumors will be randomly assigned to one of the two timing schedules. The goal is to see which …
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated May 11, 2026 20:38 UTC
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New combo therapy targets brain metastases in early trial
Disease control OngoingThis early-phase study tests the safety and best dose of the drug trametinib when given with or without whole-brain radiation for people whose cancer has spread to the brain. Ten participants will receive the combination to see how well it is tolerated and how much drug reaches t…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 08, 2026 12:00 UTC
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New hope for lung cancer patients with brain tumors: drug combo shows promise
Disease control OngoingThis study looked at whether adding bevacizumab to osimertinib helps control EGFR-mutant lung cancer that has spread to the brain. About 5 adults with this condition took part. The goal was to see if the combination slows cancer growth better than osimertinib alone.
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 29, 2026 15:05 UTC
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Precision radiation aims to spare brain function in lung cancer patients
Disease control OngoingThis study is testing a more focused radiation treatment for patients whose small cell lung cancer has spread to the brain. Instead of radiating the entire brain, which can cause side effects like memory problems, doctors use precise beams to target only the tumors. The goal is t…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Apr 22, 2026 16:00 UTC
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Could a simple pill boost Radiation's power against brain cancer?
Symptom relief OngoingThis early-phase study tests an oral drug called ropidoxuridine (IPdR) combined with whole-brain radiation in people whose cancer has spread to the brain. The goal is to find the safest dose and see if the drug makes radiation work better by sensitizing tumor cells. Only 11 parti…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Symptom relief
Last updated May 17, 2026 04:32 UTC
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Brain cancer patients may keep quality of life with early mental support
Symptom relief OngoingThis study tests whether early visits with a brain health specialist can help people with cancer that has spread to the brain maintain their quality of life after radiation therapy. About 110 adults with stage IV solid tumors and brain metastases will receive neuropsychological c…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief
Last updated May 15, 2026 11:55 UTC
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Couples tackle brain tumors together: new online program aims to ease symptoms
Symptom relief OngoingThis study tests an online mind-body program for people with brain tumors (glioma or cancer spread to the brain) and their partners. The program aims to improve spiritual well-being, sleep, mood, and overall quality of life. About 74 couples will take part to see if the program i…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated May 04, 2026 16:23 UTC
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New brain-mapping technique may protect movement during radiation
Knowledge-focused OngoingThis study looks at whether a non-invasive brain-mapping tool called nTMS can help doctors plan radiation treatment for brain tumors near the motor cortex, the area that controls movement. About 22 adults who already had radiation for brain tumors will be tested to see if nTMS pr…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 17, 2026 04:34 UTC