METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Clinical trials for METASTATIC MALIGNANT NEOPLASM IN THE BRAIN explained in plain language.
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New drug combo shows promise for lung cancer brain metastases
Disease control OngoingThis phase II trial tested whether adding bevacizumab to osimertinib works better than osimertinib alone for patients with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer) that has spread to the brain. Only 5 patients were enrolled. The goal was to see if t…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
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New cocktail of cancer drugs targets brain metastases in melanoma patients
Disease control OngoingThis Phase 2 trial tests whether combining bevacizumab (Avastin) with atezolizumab (Tecentriq), with or without cobimetinib (Cotellic), can shrink or control melanoma that has spread to the brain. The study enrolls 29 adults with untreated brain metastases who are not taking ster…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Experimental combo targets Hard-to-Treat esophageal cancer
Disease control OngoingThis early-stage trial tested a drug called adavosertib together with radiation therapy for people with advanced esophageal or stomach cancer that cannot be surgically removed. The goal was to find the safest dose and see how well the combination works. Only 4 people took part, s…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Triple threat: new combo therapy targets Hard-to-Treat melanoma
Disease control OngoingThis phase II trial is testing two different three-drug combinations in people with advanced BRAF-mutated melanoma that has spread or cannot be removed by surgery. One group receives nivolumab (immunotherapy) plus dabrafenib and trametinib (targeted therapy); the other receives n…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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New drug combo targets Hard-to-Treat lung cancer
Disease control OngoingThis early-phase trial is testing two oral drugs, Sapanisertib and Telaglenastat, in 22 people with advanced non-small cell lung cancer that has spread to the brain or other organs. The drugs work by blocking key enzymes that cancer cells need to grow. The main goal is to find th…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Brain tumor treatment showdown: should radiation come before or after surgery?
Disease control OngoingThis phase III trial tests whether giving focused radiation (stereotactic radiosurgery) before surgery is better than after surgery for people with 1 to 4 brain metastases. About 237 participants will be randomly assigned to one of the two sequences. The goal is to see which orde…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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New combo therapy shows promise for lung cancer brain metastases
Disease control OngoingThis study is for people with advanced non-small cell lung cancer that has spread to the brain. It tests whether adding immunotherapy drugs (nivolumab with or without ipilimumab) to radiation therapy can better control the cancer. The goal is to find the safest and most effective…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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Smart drug targets breast cancer in the brain
Disease control OngoingThis phase II trial tests a drug called sacituzumab govitecan in 44 patients with HER2-negative breast cancer that has spread to the brain. The drug is a targeted antibody that delivers chemotherapy directly to cancer cells. The goal is to see if it can shrink brain tumors or slo…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Experimental combo targets lung cancer brain metastases in early trial
Disease control OngoingThis early-phase trial is testing the safety and best dose of a drug called berzosertib when given together with whole brain radiation therapy. The study includes 15 people with lung cancer that has spread to the brain. The goal is to find out if this combination is safe enough t…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Brain cancer trial: one big dose or several small doses of radiation?
Disease control OngoingThis phase III trial tests whether giving several small doses of radiation (fractionated radiosurgery) after removing a brain tumor is better than a single large dose. About 242 patients with cancer that spread to the brain will be randomly assigned to one of the two radiation pl…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Engineered immune cells target brain tumors in new trial
Disease control OngoingThis early-stage trial tests a treatment called HER2-CAR T cells for people with HER2-positive cancers that have spread to the brain or its lining. The cells are given directly into the brain's fluid spaces to try to kill tumor cells. The main goals are to find the safest dose an…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New combo tackles brain tumors: drug plus radiation
Disease control OngoingThis early-phase trial tests the drug trametinib, which blocks enzymes that help cancer cells grow, given with or without whole-brain radiation. The goal is to find the safest dose and see how well the drug reaches the brain. Ten adults with brain metastases from other cancers ar…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Gene-Guided drugs aim to shrink brain tumors
Disease control OngoingThis phase 2 trial tests whether genetic testing can help doctors pick the right targeted drug for people whose solid tumors have spread to the brain. About 50 participants with specific gene mutations (like NTRK, ROS1, CDK, PI3K, or KRAS G12C) will receive one of four drugs: abe…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Zapping brain tumors without zapping memory: new trial for melanoma patients
Disease control OngoingThis phase II trial is testing whether a precise, high-dose radiation treatment called stereotactic radiosurgery can control melanoma that has spread to more than three spots in the brain. The study includes 49 patients and also checks whether this approach helps preserve memory …
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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Precision radiation may spare brain function in lung cancer patients
Disease control OngoingThis study looks at whether using focused radiation (stereotactic radiosurgery) only on the brain tumors, instead of the whole brain, can help preserve thinking and memory in people with small cell lung cancer that has spread to the brain. About 55 participants will receive this …
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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Brain cancer breakthrough? new radiation after surgery may stop tumors
Disease control OngoingThis study tests whether a precise type of radiation called stereotactic radiosurgery, given after surgery to remove brain tumors, can prevent the tumors from coming back. About 132 patients with up to 3 brain metastases will be randomly assigned to receive either the radiation o…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE3 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Experimental drug aims to boost radiation against brain cancer
Symptom relief OngoingThis early-stage study tests an oral drug called ropidoxuridine (IPdR) combined with whole brain radiation in people whose cancer has spread to the brain. The goal is to find the safest dose and see if the drug makes radiation more effective at killing tumor cells. About 11 adult…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Symptom relief
Last updated Jun 27, 2026 12:26 UTC
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New radiation approach may spare thinking skills in brain cancer patients
Symptom relief OngoingThis study compares two radiation treatments for people whose non-melanoma cancer has spread to the brain with 4 to 15 tumors. One method, stereotactic radiosurgery, delivers a high dose only to the tumors, while the other treats the whole brain. The goal is to see which better c…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE3 • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Couples tackle brain tumors together with online Mind-Body program
Symptom relief OngoingThis study tests an online mind-body program designed for people with brain tumors (glioma) and their partners. The program aims to improve spiritual well-being, sleep, mood, and overall quality of life for both. Researchers are enrolling 74 couples to see if the program is pract…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Brain cancer patients may keep quality of life with early mental support
Symptom relief OngoingThis study tests whether early visits with a brain health specialist can help people with cancer that has spread to the brain maintain their quality of life after radiation therapy. About 110 adults with solid tumors and brain metastases will receive neuropsychological care along…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: PHASE2 • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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New Brain-Mapping tool could prevent nerve damage during radiation
Knowledge-focused OngoingThis study tests whether a non-invasive brain-mapping tool called nTMS can help doctors plan radiation treatment for brain tumors near the motor cortex—the area that controls movement. About 22 adults who already had radiation for brain tumors will undergo nTMS to see if it provi…
Matched conditions: METASTATIC MALIGNANT NEOPLASM IN THE BRAIN
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC