METASTATIC COLORECTAL CANCER

This study compared two different drug combinations for treating advanced colorectal cancer that has spread to other parts of the body. Researchers tested whether a new drug called A140 works as well as an existing drug called Erbitux when both are combined with standard chemothe…

This study tested the safety and effectiveness of combining two cancer drug regimens—regorafenib and FOLFIRINOX—for patients with advanced colorectal cancer that has spread and has a specific RAS gene mutation. The main goal was to find the highest dose patients could tolerate wi…

This early-stage trial tested a new oral drug, ERAS-007, in combination with other cancer therapies for people with advanced colorectal or pancreatic cancer. The main goals were to find the safest and most effective dose and to see if the drug combinations could shrink tumors. Th…

This study tested whether adding the drug panitumumab to standard chemotherapy could help people with colorectal cancer that had spread to their liver stay cancer-free longer after surgery. It involved 75 patients whose cancer had been surgically removed from the liver and who ha…

This study tested whether adding the drug sorafenib to standard chemotherapy (irinotecan) could help control advanced colorectal cancer that had stopped responding to prior treatments. It involved 64 patients whose cancer had a specific genetic change (K-RAS mutation) and had spr…

This study followed 704 French patients with advanced colorectal cancer who received regorafenib through a compassionate access program. Researchers wanted to understand how well the drug worked and what side effects occurred in real-world clinical practice, outside of strict cli…

This study tested the safety and best dose of a combination of two drugs, regorafenib and nivolumab, for people with advanced colorectal cancer that had stopped responding to standard treatments. The main goal was to see how much of the drug combination patients could tolerate an…

This study tested an experimental immunotherapy called STIMVAX for people with advanced colorectal cancer that had stopped responding to two previous chemotherapy treatments. The treatment uses specially prepared immune cells from healthy donors to try to teach the patient's own …

This study tested whether adding the immunotherapy drug pembrolizumab to standard radiation or tumor ablation could help control metastatic colorectal cancer. It involved 34 patients whose cancer had spread and who had already tried at least two standard treatments. Researchers w…

This study tested new combinations of drugs, including an experimental one called etrumadenant, for people with advanced colorectal cancer that has spread. It involved 227 participants and aimed to see if these combinations could control the cancer better than standard treatments…

This study tested whether giving two cancer drugs (cetuximab and capecitabine) less often could safely help control advanced colorectal cancer that had responded to initial treatment. It involved 24 adults with a specific genetic type of cancer that had spread. The main goals wer…

This study tested whether simple blood tests taken early in treatment could predict how well chemotherapy would work for people with advanced colorectal cancer. Researchers followed 74 patients receiving first-line chemotherapy to see if changes in certain cancer markers in their…

This study aimed to see if a new, non-invasive urine test could help monitor how well chemotherapy is working for people with advanced colorectal cancer. Researchers collected urine and saliva samples from 16 patients before and after starting chemotherapy. They measured specific…

This study looked back at the medical records of 274 European patients with a specific, aggressive form of metastatic colon cancer (with a BRAF V600E mutation). The goal was to understand what treatments doctors actually used in the real world between 2016 and 2018, and how well …

This study aimed to understand if certain markers in urine follow daily patterns in people with metastatic colorectal cancer. Researchers collected urine samples from 32 participants (half with cancer, half healthy) over two days to measure these patterns. The goal was to gather …

This study looked at existing medical records to understand if the order in which patients receive certain cancer treatments affects how long they live. Researchers examined data from 121 people in Europe with advanced colorectal cancer who had already tried multiple treatments. …