METASTATIC COLORECTAL CANCER

This phase 3 trial tested a drug called A140 (similar to cetuximab) combined with chemotherapy (mFOLFOX6) as a first treatment for people with a specific type of advanced colorectal cancer (RAS wild-type). The study planned to enroll 570 people in China but was terminated early w…

This study tested a combination of two drugs, VB-111 and nivolumab, in 14 adults with colorectal cancer that had spread to the liver. The goal was to see if the treatment was safe and could shrink tumors. The trial was terminated early, but researchers collected data on side effe…

This phase 2 trial tested a combination of three drugs—nivolumab (an immunotherapy), tadalafil (commonly used for erectile dysfunction), and vancomycin (an antibiotic)—in adults with liver cancer or liver metastases from colorectal or pancreatic cancers that had not responded to …

This early-phase study tested a new treatment called LCAR-G08, which uses a patient's own immune cells (T-cells) that are modified in a lab to recognize and attack cancer cells in the gut. The study included 17 adults with advanced colorectal, stomach, pancreatic, or small bowel …

This early-stage study tested whether adding curcumin (a compound in turmeric) to standard chemotherapy could help patients with metastatic colon cancer that no longer responds to 5FU. The goal was to check safety and see if the combination shrinks tumors. Only 15 people were enr…

This early-phase trial tested a gene therapy approach for metastatic cancer that produces a protein called CEA. Researchers took white blood cells from patients, added a gene to help them target CEA, and infused them back along with chemotherapy and a drug called IL-2. Only 3 peo…

This study followed 28 adults with liver, colorectal, melanoma, or kidney cancers who received high-dose radiation therapy. Researchers collected blood samples before, during, and after treatment to track immune cells and other markers. The goal was to learn how the immune system…

This study aimed to see if a simple blood test (liquid biopsy) could help doctors make better treatment decisions for people with advanced cancers of the colon, pancreas, or bile duct. Researchers planned to enroll about 130 participants but stopped early with only 16 enrolled. T…