Experimental immune cell therapy shows promise for Tough-to-Treat colon cancer

NCT ID NCT04444622

Completed Disease control Sponsor: Mirror Biologics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed Phase IIB trial tested an experimental immunotherapy called STIMVAX (AlloStim) in 29 adults with metastatic colorectal cancer that had not responded to two prior chemotherapy regimens. The treatment uses immune cells from healthy donors to try to fight the cancer. The study measured overall survival and safety to see if this approach could be a new option for patients with limited choices.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: STIMVAX (AlloStim) - immune cells from healthy donors
What this could lead to: If successful, this could offer a new treatment option for people with advanced colorectal cancer who have run out of standard chemotherapy options.
What could go wrong: This is a small, early-phase trial (Phase IIB) with only 29 participants, so results may not apply to everyone. The treatment is experimental and may cause side effects or not improve survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC COLORECTAL CANCER

Contacts and locations

Locations

Hirschfield Oncology Center

The Bronx, New York, 10469, United States
Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Mt. Sinai Comprehensive Cancer Center

Miami Beach, Florida, 33140, United States
Summit Health

Florham Park, New Jersey, 07932, United States

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