MENTAL HEALTH ISSUE

This study looks at whether taking part in a traditional Ojibwe ceremony called Gii'igoshimong can help American Indian adults cut down on substance use and improve their mental health. About 300 adults who identify as Ojibwe/Anishinaabe/Chippewa and have used substances in the p…

This study tests whether giving pasteurized donor human milk to full-term babies of mothers with diabetes during the first five days of life can reduce the number of infants admitted to the neonatal unit for low blood sugar. About 1,444 mothers and their newborns will be randomly…

This study tests a 10-session counseling program called STEP-AD for Black women living with HIV who have a history of trauma. The goal is to help them stick to their HIV medication and achieve viral suppression. Researchers will enroll 250 participants and compare the program to …

This study tests a new way to train mentors and their supervisors to deliver a proven depression prevention program to teens in rural communities. The training uses online modules, live coaching, and a buddy system where new mentors learn from experienced ones. About 96 teens age…

This study tests a program called Family Spirit Strengths (FSS) designed to help American Indian and Alaska Native mothers and caregivers cope with stress, build skills, and connect with their culture. About 188 participants will either receive FSS or a nutrition education progra…

This study tests two school-based programs designed to help teenagers aged 13-19 sleep better. The goal is to see if improving sleep can prevent depression, anxiety, and daytime sleepiness. About 3000 students in Swedish high schools will take part, and their results will be comp…

This study tests a peer-led community program to help Black men in Prince George's County, Maryland, start taking PrEP, a daily pill that prevents HIV. The program uses in-person events to reduce stigma, build social support, and teach skills for getting HIV care. Researchers wil…

This study tests a 10-session LGBTQ-affirmative cognitive behavioral therapy (CBT) delivered via telehealth to sexual minority women who drink heavily and have anxiety or depression. Researchers will compare it to standard LGBTQ-affirmative therapy to see if it better reduces hea…

This study tests whether a virtual reality program that teaches mindfulness and emotional regulation can reduce burnout in healthcare workers. One hundred staff from participating hospitals will be randomly assigned to either start the 8-session VR program right away or after a w…

This study tests whether adding two check-in calls per week to standard cognitive behavioral therapy (CBT) improves quality of life for adults caring for a family member with dementia in rural Texas. Sixty caregivers will receive either individual CBT for 12-16 weeks or CBT plus …

This study tests whether online (telehealth) programs can reduce pre-death grief, burden, and stress in family caregivers of people with dementia. About 60 adult caregivers who speak English and have a mental health condition like anxiety or depression will take part. The goal is…

This study tests a program called SUPERCEDE, which provides intensive case management to veterans who are at risk for suicide and receive care both from the VA and outside community providers. The goal is to improve care coordination, reduce suicidal thoughts, and improve daily f…

This study is testing whether online therapy programs can help people with moderate to severe anxiety or depression. 320 participants will be randomly assigned to guided online CBT, self-guided CBT, mindfulness, or a waitlist. The goal is to see which approach best improves menta…

This study tests a 6-month online program called HELP that helps teens aged 12-17 with emotional distress improve their lifestyle habits like physical activity, sleep, and screen time. Researchers will compare emotional health and healthcare use between teens who get the program …

This study compares music-backed mindfulness meditation to meditation alone for reducing stress and anxiety in people of African descent. 70 participants with anxiety or depression will join virtual sessions. The goal is to see if adding music makes stress management more effecti…

This study tests whether group or individual therapy can reduce pre-death grief, burden, and stress in people caring for a loved one with dementia. About 60 informal caregivers (family or close friends) will participate. The goal is to improve their emotional well-being during a …

This study tests two types of talk therapy—individual LGBTQ-affirmative CBT and family-based therapy—delivered online to LGBTQ+ adults (age 20+) who have nonaccepting parents. The goal is to see if these therapies reduce depression and anxiety symptoms. The trial is currently rec…

This study tests whether an 8-week health education program called Living Healthy, plus support from a trained peer coach (another home health aide), can improve mood and well-being in home health aides. 100 aides with mild depression, stress, or loneliness will be randomly assig…

This study tests a brief video-based cognitive behavioral therapy (BRIGHT) to reduce body image distress in 180 head and neck cancer survivors. Participants are randomly assigned to either BRIGHT or a supportive care control group. The goal is to see if BRIGHT can help survivors …

This study tests an online program called POET that teaches teens aged 12-17 how to understand and regulate their emotions. The goal is to reduce mental health symptoms like anxiety and depression. The trial will include 388 participants and follow them for up to 10 years to see …

This study is testing a therapy program called the Unified Protocol for Children (UP-C) and Adolescents (UP-A) to help young people aged 7-17 with anxiety, depression, or other emotional difficulties. The program involves up to 24 sessions with a therapist, either in groups or in…

This study tests a package of strategies (like mindfulness training and schedule changes) to reduce burnout and turnover in 60 therapists who deliver trauma-focused therapy to children. The goal is to help therapists stay in their jobs longer, so more kids can get consistent, eff…

This study examines whether climate anxiety is linked to suicidal thoughts and behaviors in young people aged 16 to 24 who are receiving psychiatric care. Researchers will use questionnaires to measure climate anxiety, general anxiety, and suicide risk in 108 participants. The go…

This study looks at how stress and social support might influence preterm birth in 200 pregnant women, especially among Black and Hispanic women who face higher risks. Researchers will measure stress levels, immune responses, and cellular energy (mitochondria) to understand why s…

This study looks at the mental health of teenagers in Ecuador, ages 14 to 19. Researchers want to understand how lifestyle and social factors affect emotional well-being. They will use surveys and follow-ups to gather information. The goal is to create better programs and policie…

This study tests whether a Personalized Therapeutics Clinic (PTC) can lower the risk of harmful drug interactions in cancer patients. Participants get genetic testing to see how their medications interact with each other and with their genes. The goal is to help doctors prescribe…

This study will measure how many women at a high-risk pregnancy clinic experience postpartum depression. Researchers will use a standard questionnaire called the Edinburgh Postnatal Depression Scale (EPDS) to screen 100 women who gave birth 4 weeks to 6 months ago. The goal is to…

This study tests whether a virtual, community-based program combining music and mindfulness can help People of African Descent manage stress, anxiety, and depression during COVID-19. Researchers will measure brain activity and feelings of social connection in 48 participants as t…

This study follows 235 adults who survived acute respiratory failure (ARF) and their family caregivers. Over 6 months, they complete surveys about their expectations, mood, and coping. The goal is to see if positive or negative expectations are linked to anxiety, depression, and …

This study tests whether a simple team debriefing tool, called an After-Action Review, can help child welfare teams better connect children and families to mental health services. Researchers will work with 320 participants, including caseworkers and family members, to see if the…

This study explores whether teachers can be trained to deliver mental health support to teenagers in rural India. About 216 students from 60 low-cost private schools will take part. The goal is to see if this approach is practical and effective for improving teen mental health.

This study is testing a group program called Weyera to see if it helps Ethiopian and Eritrean young adults (ages 18-29) in Atlanta feel better mentally and emotionally. The program focuses on building resilience and coping skills. Researchers want to know if the program is accept…

This study aims to see if an online screening tool can help find mental health problems in children aged 5-17 who were born with heart defects. Researchers will ask parents and children to complete questionnaires and check if they meet criteria for psychiatric diagnoses. The goal…

This study looks at whether training psychiatric care teams to talk about sexual health with young patients (ages 15 and up) increases those conversations. Researchers will survey 770 teens hospitalized for psychiatric disorders about their sexual health and any side effects from…