DYSLIPIDEMIAS

This study tests whether nattokinase, an enzyme from fermented soy (natto), can reduce inflammation and improve heart health markers in people with high cholesterol. About 48 adults with dyslipidemia will take nattokinase or a placebo for two months. Researchers will measure chan…

This study is testing a program called PILI 'Āina for Native Hawaiians with type 2 diabetes, high blood pressure, high cholesterol, or overweight. The program promotes traditional Hawaiian diets and cooking to improve health and social connections. About 210 adults will take part…

This study tests a program called PILI 'Āina that helps Native Hawaiians manage type 2 diabetes, high blood pressure, and weight by returning to traditional diets and cooking methods. About 1,780 adults who are overweight and have these conditions will take part. The goal is to i…

This study is testing a combination pill (Pitavastatin/Ezetimibe) to lower cholesterol in 10,000 adults who have both high cholesterol and metabolic syndrome. Researchers will measure how much LDL-C (bad cholesterol) drops after 24 and 48 weeks, and check for side effects. Partic…

This study tests whether a new drug (obicetrapib) taken alone or with another drug (evolocumab) can lower a type of fat in the blood called lipoprotein(a), which is linked to heart disease. About 69 adults with mildly high cholesterol and elevated Lp(a) will take the drugs for 16…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV who are on effective treatment. About 121 adults aged 40 and older with controlled HIV and at least one heart risk factor will receive …

This study looks at whether adding omega-3 (fish oil) to a common cholesterol-lowering statin can reduce plaque buildup in the carotid arteries of people with type 2 diabetes and high cholesterol. About 105 adults will be randomly assigned to receive either atorvastatin plus omeg…

This study looks at whether group medical visits, where several patients see a doctor together, can help people with high cholesterol improve their health. Researchers will enroll 288 adults with dyslipidemia to test if this approach improves cholesterol levels and lifestyle habi…

This early-phase study tests a single-dose CRISPR treatment (CTX310) designed to edit a gene that controls fat levels in the blood. It is for adults aged 18 to 75 with severe high cholesterol or triglycerides that do not improve with standard medications. The main goal is to chec…

This study looks at whether eating milk polar lipids (a type of fat found in milk) every day can improve cholesterol levels, reduce inflammation, and support gut health in adults with high cholesterol and belly fat. About 130 participants will take part in this early-stage trial.…

This study tests an experimental drug called RBD5044 in 120 adults with mixed dyslipidemia, a condition where blood fat levels are too high. Participants will receive either the drug or a placebo twice over 12 months to see if it safely lowers triglycerides. The goal is to contro…

This study is following 1,000 people who are having weight-loss (bariatric) surgery to see how their bodies change over two years. Researchers will measure weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits. The goa…

This study is following 2,500 adults aged 30-75 in Puerto Rico to learn how stress, diet, and where they live affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years, including before and after…

This study tests whether a computer alert system can help doctors remember to prescribe cholesterol-lowering medications to people with peripheral artery disease (PAD) who aren't currently taking them. About 400 adults with PAD will take part. The goal is to see if the alerts lea…

This study looks at whether cholesterol tests taken during a heart attack hospital stay give reliable results. About 100 adults admitted for a heart attack will have their cholesterol checked at the start, two days later, and again 4-6 weeks after leaving the hospital. The goal i…

This study aims to find out how common chronic kidney disease (CKD) is in semi-rural Sub-Saharan Africa and what factors increase the risk. Researchers will follow 1,200 adults for one year, measuring kidney function and checking for conditions like diabetes, high blood pressure,…

This study follows 300 people having metabolic (weight-loss) surgery to see how their gut bacteria change over time and how those changes relate to improvements in heart health, diabetes, and cholesterol. Participants provide stool, blood, and tissue samples before and up to 3 ye…

This study is enrolling 20,000 adults in Taining County, China, to better understand common chronic diseases like high blood pressure, diabetes, and frailty. Researchers will collect health data and samples over three years to find patterns and risk factors. The goal is to create…

This study looks at how high blood pressure, diabetes, and high cholesterol change the tiny blood vessels in the back of the eye. Researchers will use a special, non-invasive eye scan called OCTA to measure these changes in 300 adults. Participants will be followed for five years…

This study is like a big health check-up for 600 U.S. Army soldiers. Researchers will look at what they eat, their heart health, body composition, mental well-being, and physical fitness. The goal is to gather information to help improve soldier health and readiness, not to test …