DIABETES

This study looks at whether adding a low dose of the diabetes medication insulin detemir to a low-calorie diet helps people with obesity and type 2 diabetes lose more weight and improve brain function related to food reward. 240 adults aged 31-60 will be randomly assigned to eith…

This study looks at whether having a cancer survivor's regular doctor work closely with their cancer team can better manage heart-related conditions like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers (like breast, prostate, or lung) an…

This study compares two treatment plans for people who develop diabetes from taking steroids. One plan uses a combination of a GLP-1 receptor agonist and long-acting insulin, while the other uses standard intensive insulin therapy. The goal is to see which approach better control…

This study compares a new diabetes-specific nutritional formula to an existing one in 103 adults with type 1 diabetes, type 2 diabetes, or prediabetes who are at risk for malnutrition. The goal is to see if the new formula is as good as the current one at improving nutrition, mea…

This study tests a new insulin called GZR4 that is given just once a week, compared to a standard daily insulin, in 620 adults with type 2 diabetes. The goal is to see if the weekly shot controls blood sugar just as well or better, with fewer injections and similar safety. Partic…

This study aimed to see if placing a stent in a blocked leg vein could help heal diabetic foot ulcers faster. It planned to compare standard wound care plus a stent versus standard care alone in people with diabetes, foot ulcers, and leg swelling. However, the trial was withdrawn…

This study looks at whether giving people with obesity and diabetes a monthly $160 subsidy for fruits and vegetables helps them buy more healthy food. 214 adults will be split into groups, some getting the subsidy and some not, for 3 months. Researchers will track how much produc…

This study tests whether a natural compound called maslinic acid, found in olives, can safely improve metabolic health in 50 Chinese adults with excess weight or early signs of metabolic syndrome. Participants take the supplement for 12 weeks while researchers measure changes in …

This study tests whether giving people free boxes of fruits and vegetables along with nutrition tips can help manage conditions like diabetes, high blood pressure, and obesity. About 300 adults from three Mississippi counties with high poverty and health disparities will take par…

This study looks at how well the Joslin Why WAIT? program works for people with type 2 diabetes and a BMI over 35. The program focuses on weight loss and intensive treatment to improve health. Researchers are measuring weight loss, blood sugar control, and cholesterol levels in 1…

This study tests a program where community paramedics visit adults with diabetes who have had severe low blood sugar (hypoglycemia). The goal is to help them better manage their diabetes, prevent future emergencies, and improve their quality of life. The program involves educatio…

This study tests a new insulin called GZR4 that is given once a week, compared to a standard daily insulin (glargine). Both groups also use a fast-acting insulin at meals. The goal is to see if the weekly shot works as well or better at controlling blood sugar, with fewer side ef…

This study tests whether an artificial intelligence (AI) system can help find diabetic eye disease earlier during regular doctor visits. About 1,700 adults with diabetes who haven't had an eye exam in the past year will be screened using AI at their primary care clinic. The goal …

This study evaluates a home collection kit that lets people with diabetes mail in a small blood sample to check their HbA1c levels, a key marker of blood sugar control. About 63 adults with Type 1 or Type 2 diabetes will try the kit and give feedback. The goal is to see if the ki…

This study looks at whether giving extra support—like phone calls and more resources—to people who aren't losing weight early in a diabetes prevention program can help them succeed. It involves 403 Black adults without diabetes who are overweight. The goal is to prevent diabetes …

This study looks at whether taking a daily extract of yerba mate (a traditional South American drink) can improve health markers like weight, blood sugar, and cholesterol in overweight adults. Eighty people aged 40-65 will take either the extract or a placebo for 90 days. Researc…

This study tests a new way of caring for children under 10 with diabetes. The clinic uses play, calmness training, healthy lifestyle advice, and parent support groups to improve quality of life for both kids and their families. About 100 children and their parents will take part …

This study looks at whether a mindfulness-based stress reduction program and yoga can lower stress, improve quality of life, and help control blood sugar in teenagers with type 1 diabetes. About 90 teens aged 13-18 will take part. The goal is to see if these mind-body practices c…

This study tests a culturally tailored support program for 300 Chinese and Korean American adults (age 50+) who care for a relative with dementia. The program combines counseling with online peer support groups. The goal is to see if it reduces stress, depression, and health risk…

This study looks back at medical records of 46,000 diabetic patients who had surgery in Alberta, Canada. Researchers want to see how many had their blood sugar control (HbA1C) checked before surgery and whether poor control leads to more complications or longer hospital stays. Th…

This study is creating a large biobank of 48,000 people with diabetes in Hong Kong. Researchers will collect blood samples and health data to find genetic markers that predict serious complications like kidney failure, heart disease, and stroke. The goal is to improve early detec…

This study aims to understand why people of African ancestry have high rates of type 2 diabetes, obesity, and heart disease. Researchers will collect blood samples and health information from 1,100 adults who identify as African American, Afro-Caribbean, or migrants from sub-Saha…

This study looks at whether using a Fitbit and a continuous glucose monitor is a practical way to track daily exercise in people with cancer or diabetes. About 35 adults who are not very active will wear these devices for a period of time. The goal is to see if people are willing…

This study looks at how certain immune proteins, called the complement system, may make kidney disease worse in people with diabetes. Researchers will measure these proteins in blood and urine from 90 participants to see if they are linked to kidney damage and blood vessel health…

This study aims to discover new biological markers (called microRNAs) in the blood that could help identify and understand Adult Onset Autoimmune Diabetes. Researchers will collect blood samples from 25 adults with type 1 diabetes to look for changes in these markers. The goal is…

This study looks at how skin temperature changes in people who have a leg amputation and diabetes. Researchers want to understand what affects temperature and blood flow in the remaining leg and the other foot. They will also test if a special shock-absorbing prosthetic leg can h…

This study looks at 40 young boys who play soccer—some have type 1 diabetes, some don't—to see how their bodies differ in muscle, fitness, and temperature control during exercise. Researchers will use thermal cameras and continuous glucose monitors to track changes in real time. …

This study aims to reduce health gaps in Black and Latino communities by connecting people with health and social services. Researchers will track how many participants use these services and how satisfied they are. The goal is to build trust and improve health for those with dia…

This study is a review of many smaller trials that looked at what happens when people replace animal proteins (like meat, dairy, eggs) with plant proteins (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weigh…

This study tests a new way of organizing care for chronic diseases like high blood pressure, diabetes, and kidney disease in Thailand. Researchers will work with 16 primary care clinics to see if using patient data in real time helps doctors and nurses provide better care. The go…

This study aims to create a digital tool that uses information already collected during hospital stays—like blood tests and blood pressure—to identify patients who may have undiagnosed chronic conditions such as diabetes or heart disease. By analyzing millions of patient records,…

This study looks at adults with cystic fibrosis to understand how having diabetes impacts their quality of life, lung function, and nutrition. Researchers will compare those with and without diabetes using questionnaires and breathing tests. The goal is to gather information to i…