DIABETES

This study looks at whether a tighter blood sugar target (70-140 mg/dL) can improve diabetes control in 120 children and teens with Type 1 Diabetes who use automated insulin pumps. Participants will be randomly assigned to either the standard target or the tighter target for 12 m…

This study tests a 6-week program for older adults (55+) who have both diabetes and mild memory or thinking problems. Participants attend weekly group sessions with their caregiver to learn better diabetes self-care. The goal is to see if the program improves blood sugar control …

This study tests whether an AI-powered tool can help community doctors improve control of high blood pressure, diabetes, and high cholesterol in 6,800 adults. Participants will be randomly assigned to either AI-assisted care or usual care. The goal is to see if the AI helps more …

This study looks at the safety and performance of the Endogenex System in 50 adults with type 2 diabetes. Participants previously received a sham (fake) procedure in an earlier study. The goal is to see if the device is safe and works well for managing diabetes.

This study tests a combination of four drugs (epalrestat, liver-directed chemotherapy, donafenib, and tislelizumab) as a first treatment for people with advanced liver cancer that cannot be removed by surgery and who also have diabetes. The goal is to see if this mix can stop the…

This study will give 4,450 low-income adults with diabetes or hypertension a monthly food card benefit of either $80 or $120. Researchers want to see if the extra grocery support helps reduce food insecurity and improves key health measures like blood sugar and blood pressure. Pa…

This study tests whether an enhanced Diabetes Prevention Program that includes healthy food deliveries and exercise classes can help African American adults with prediabetes lose more weight than a standard program. About 408 participants from low-income communities will take par…

This study looks at whether pregnant women with type 1 or type 2 diabetes can safely keep using their insulin pump during labor instead of switching to IV insulin. About 30 women who already use an insulin pump will be allowed to continue using it while giving birth. The goal is …

This study tests if a mild electrical pulse to the ear can stimulate the vagus nerve and reduce nausea, vomiting, and stomach pain in people with diabetes and gastroparesis. Researchers will enroll 60 adults who have had gastroparesis for at least a year. The goal is to see if th…

This study tests whether the drug sodium phenylbutyrate (NaPB) can improve blood pressure and blood vessel function in people with diabetes. Researchers will compare results from 30 healthy volunteers and diabetes patients. The goal is to see if NaPB can ease vascular problems li…

This study looks at whether a special phone app can reliably send blood sugar readings from children with diabetes to the hospital's computer system. Currently, these readings are only available on a bedside device or phone app, not to the care team in real time. The study will e…

This study looks at how meals with different amounts of fat, carbs, and protein change fat levels in the blood. Researchers will study 100 adults with conditions like diabetes, metabolic syndrome, or kidney disease, plus healthy volunteers. Participants will eat two different bre…

This pilot study will test if a program that provides education, motivation, and social support can help prevent kidney disease from worsening in 50 adults with diabetes and early-stage chronic kidney disease. Participants will meet virtually with a nurse and complete surveys ove…

This study will collect health information and samples (blood, saliva, urine, stool) from up to 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or metabolic problems. Researchers want to learn how diabetes and obesity develop and change over many years. Parti…

This study is testing a new, noninvasive device called the Argus CGM that uses light and AI to estimate blood sugar levels without needles or skin punctures. Up to 100 adults with type 1 diabetes, type 2 diabetes, or prediabetes will wear the device for 15 days while researchers …

This study tests a method called 'audit and feedback' to help primary care providers follow best practices for high blood pressure and diabetes. Researchers will give some providers reports on how well they are doing and compare their care to providers who get no feedback. The go…

This study looks at how physical activity changes during pregnancy in women with type 1 or type 2 diabetes, and how it relates to blood sugar control and mental health. About 175 pregnant women will wear activity monitors and complete surveys. The goal is to learn what support th…

This study is testing a new AI-powered tool called AIManage that helps doctors and patients manage medications for diabetes and obesity. The tool will provide guidance on adjusting doses. The study involves 16 participants and will first gather feedback on how useful and easy the…

This study will collect health information from 10,000 adults with diabetes, metabolic disorders, or related conditions like high blood pressure and fatty liver. Researchers will track things like blood sugar, weight, and lab results over at least 10 years to find better ways to …

This study looks at whether having a team of heart experts discuss treatment decisions in real time during a procedure can improve outcomes for people with diabetes and severe blockages in all three main heart arteries. About 1,350 participants will be randomly assigned to either…

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—this is an observation-only study to better understand the…

This study looks at how healthy, non-diabetic adults from the Old Order Amish community respond to sitagliptin, an FDA-approved diabetes medication. Over 7 weeks, participants will have two clinic visits where they drink a sugary solution and give blood samples to measure insulin…