CERVICAL CARCINOMA

This study tested the drug pembrolizumab in over 1,600 people with various advanced solid tumors that had stopped responding to standard treatments. The goal was to see if the drug could shrink or control the tumors. The trial focused on identifying which patients were most likel…

This study tests a combination of two drugs (zimberelimab and lenvatinib) in 30 people with advanced cervical cancer that got worse after prior immunotherapy. The goal is to see if this combo can shrink tumors or slow the disease. Participants must have tried platinum-based chemo…

This study tests a drug called XmAb20717 in 140 adults with advanced rare cancers, such as mesothelioma and Hodgkin's lymphoma. The goal is to see if the drug can shrink tumors and how safe it is. The trial is currently on hold.

This is a first-in-human study to test the safety and find the right dose of an experimental pill called ATV-1601. It is for adults with advanced solid tumors, including certain breast, gynecologic, and prostate cancers, that have a specific genetic change called an AKT1 E17K mut…

This study compares HPV testing on self-collected vaginal samples versus samples collected by a doctor during a pelvic exam. It involves 750 people referred for colposcopy or cervical procedures. The goal is to see if self-collection is accurate enough to make cervical cancer scr…

This study compares the accuracy of HPV testing on self-collected vaginal samples versus samples collected by a doctor during a pelvic exam. About 500 people referred for colposcopy or cervical procedures will provide both types of samples. The goal is to see if self-collection i…

This study compares HPV testing on self-collected vaginal samples versus samples collected by a doctor during a pelvic exam. About 500 women referred for colposcopy or cervical procedures will participate. The goal is to see if self-collection is accurate enough to increase scree…

This study looks at whether giving women a simple self-collection kit for HPV testing at Express Care clinics (which have evening and weekend hours) can increase the number of women who get screened for cervical cancer. About 500 women ages 30–63 who are overdue for screening wil…

This study looks at whether women in Uganda can prevent cervical cancer by using a self-administered HPV test at home or in community health campaigns. The test checks for the virus that can lead to cervical cancer, allowing early treatment. Over 2,500 women aged 25-49 are taking…

This study follows 72 women with pelvic cancers (like cervical or rectal) to see how radiation therapy changes their pelvic health and sexual function over two years. Researchers measure physical changes and ask about symptoms like dryness or pain. The goal is to better understan…

This early-phase study tests a new imaging agent called 68Ga-FAPI-46, which targets cells around tumors. About 26 adults with various cancers will receive the tracer and then have a PET/CT scan. The goal is to see where the tracer goes in the body and compare it to standard imagi…

This study tests whether analyzing the genes of a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to standard therapy are enrolled. The goal is to see if targe…

This study follows over 8,600 women in Costa Rica who received the HPV vaccine (types 16 and 18) and compares them to unvaccinated women. Researchers want to see how long the vaccine protects against cervical cancer and related diseases, and whether it might cause other HPV-relat…

This study follows 79 women with gynecologic cancers (cervical, endometrial, vaginal, or vulvar) who had a pelvic exenteration—a surgery removing the lower colon, rectum, and bladder. Researchers track complications, quality of life, and cancer recurrence over time to learn which…