CARDIOGENIC SHOCK

This study tests whether a special heart monitor can help prevent serious problems like death, heart failure, or repeat hospital stays in people who have survived a severe heart condition called cardiogenic shock. About 40 adults will be randomly assigned to get the monitor or st…

This study tests whether adding a balloon pump (IABP) to standard ECMO support helps people with severe cardiogenic shock recover their heart function and come off the machines sooner. About 430 adults will be randomly assigned to receive ECMO alone or ECMO plus the balloon pump.…

This study tests whether using a special heart monitor (pulmonary artery catheter) early in the hospital can lower the risk of death for people in cardiogenic shock from severe heart failure. About 400 adults will be randomly assigned to get the monitor or standard care. The main…

This study looks at whether placing a special balloon pump (IABP) early after starting ECMO can improve survival in adults with cardiogenic shock—a life-threatening condition where the heart can't pump enough blood. About 358 participants will be randomly assigned to get the ball…

This study tests whether starting kidney dialysis early helps people with severe heart shock who are on a heart-lung machine (ECMO). About 408 adults with both heart and kidney failure will be randomly assigned to early or standard dialysis. The goal is to see if early treatment …

This study tests whether setting a personalized blood pressure goal based on vein pressure improves outcomes for adults in cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. About 406 participants will be randomly assigned to either standard …

This study tests whether a personalized blood transfusion approach, based on oxygen levels, is better than the standard method for people on a heart-lung machine (ECMO) due to severe heart failure. About 236 adults will be randomly assigned to one of two strategies to see which r…

This study tests a new temporary heart pump (Magenta Elevate) in 10 people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. The pump is inserted through a blood vessel to help the heart work and stabilize blood pressure. The goal is to…

This study tests whether using less of the drug noradrenaline, by aiming for a lower blood pressure target (55 mmHg instead of 65 mmHg), can improve survival and reduce severe kidney failure in people with cardiogenic shock after a heart attack. About 776 adults will be randomly …

This study tests the Cardiohelp device, a heart-lung machine for children with severe heart failure, to see if it is safe and works well for up to 30 days. It also compares two blood thinners, heparin and bivalirudin, to find which causes fewer bleeding or clotting problems. Abou…

This study tests a temporary heart pump called iVAC 2L in 100 people with severe coronary artery disease who need high-risk angioplasty. The pump helps keep blood flowing during the procedure, which may reduce the risk of death, heart attack, or stroke. The goal is to see if the …

This study looks at whether adding a special balloon pump (called LV unloading) to a standard heart-lung machine (VA ECMO) helps people with severe cardiogenic shock. About 104 adults will be randomly assigned to get the balloon pump or not. Researchers will measure heart functio…

This study tests if getting a new heart valve right away (within 12 hours) helps people survive a severe heart condition called cardiogenic shock, compared to waiting a few days for standard care. About 30 adults with a tight heart valve and shock will take part. The goal is to s…

This study tests whether using a heart-lung machine (ECMO) before and during a complex aortic valve replacement can prevent death, cardiac arrest, or emergency surgery in high-risk patients. About 30 adults with severe aortic stenosis who are unstable or have tricky heart anatomy…

This study tests a procedure called TEER, which repairs a leaky heart valve, in people with cardiogenic shock (a life-threatening condition where the heart can't pump enough blood). About 144 participants in intensive care will be randomly assigned to either standard medical ther…

This study tests whether giving a special life-support machine (ECMO) at the scene of a cardiac arrest helps more people survive than waiting until they reach the hospital. About 90 adults under 70 who have a witnessed heart attack and receive bystander CPR will be included. The …

This study looks at whether giving a special ketone drink through a feeding tube is safe and practical for people with severe heart failure. The goal is to see if it can reach helpful levels in the blood without causing side effects like vomiting or liver problems. The study invo…

This study is a registry that will collect information on 3,000 people hospitalized with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers aim to understand patient profiles, treatments, and outcomes over time. No new tr…

This study watches 20 adults in cardiogenic shock who need a temporary heart pump (IABC). Researchers want to see if the stiffness of the arteries changes how well the pump works. They will measure blood flow and other vital signs before, during, and after the pump is used. The g…

This study is observing 1,000 people hospitalized with acute heart failure to learn how to better predict their outcomes. Researchers will use blood tests, imaging, and other measurements to identify different patient types. The goal is to improve future treatment and care for th…

This study is a large registry that will collect data on how the CytoSorb device is used in real-world intensive care units. It aims to track outcomes like death rates in the ICU and hospital for patients with serious conditions such as septic shock, ARDS, and liver failure. The …

This observational study looks at 600 adults hospitalized with acute heart failure or cardiogenic shock. Researchers will collect information from routine care, plus blood and urine samples, to see if they can better identify different types of heart failure and predict the risk …

This study follows 350 people who survived cardiogenic shock (a severe heart condition) after they leave the hospital. Researchers want to see how many survive or need to go back to the hospital over time. The goal is to learn what challenges patients face and build better suppor…

This study looks back at data from 100 adults with cardiogenic shock who received an Impella 5.5 heart pump. Researchers aim to build a computer tool that uses pump and ICU data to predict whether a patient's heart will recover or if complications may arise. The goal is to help d…

This study follows 500 people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect data from four specialized centers to understand what treatments work best and why some patients do better than others. No…

This study looks back at medical records of 3,000 people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers want to see if survival rates improved after a special heart shock team started working at Inova hospital in 2017. Th…

This study looks at how genes affect the immune system and treatment responses in people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect blood samples from 300 patients to identify genetic patterns li…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life support machine for severe heart or lung failure. Researchers will collect data from 120 adults in UK intensive care units to understand current practices. They will then work with patients, f…