CARDIOGENIC SHOCK

This study tests if the drug istaroxime can help adults with mild to moderate cardiogenic shock caused by acute heart failure. About 600 participants will receive either istaroxime or a placebo through an IV for 48 hours. Researchers will measure changes in blood pressure, breath…

This study compares two drugs, norepinephrine and dopamine, to see which works better as the first treatment for adults with cardiogenic shock—a life-threatening condition where the heart can't pump enough blood. About 512 participants will be randomly assigned to receive one of …

This study tests whether using a heart pump (Impella 5.5) along with standard heart failure medications can help people with severe heart failure and shock recover without needing a heart transplant or permanent artificial heart. About 250 adults with weak hearts (ejection fracti…

This early-stage study tests a new treatment made from donor immune cells designed to calm inflammation after a severe heart attack that causes cardiogenic shock. The trial will enroll 18 adults who have had emergency artery-opening procedures. The main goals are to check safety …

This study tests whether routinely placing a small tube (catheter) in the leg can prevent serious limb complications in patients on a heart-pump machine. About 500 adults with severe heart failure or shock will be randomly assigned to get the tube placed right away or only if nee…

This study tests a new device called SynFlow Duro, a temporary heart pump for people who go into severe shock after heart surgery. The pump helps the heart recover or keeps patients stable until they can get a transplant or a permanent heart pump. About 60 adults in China will ta…

This study tests if giving a short course of steroids (methylprednisolone) for 7 days can help adults with heart failure who are in cardiogenic shock, a serious condition where the heart can't pump enough blood. The goal is to reduce harmful inflammation and help patients recover…

This study will collect information from about 1,200 patients who received ECMO (a machine that helps the heart and lungs) at a hospital in Martinique. The goal is to track survival and complications to better understand how ECMO is used in the region. No new treatments or proced…

This study tests a new, non-invasive device called ODIN that measures how well oxygen is being used in the tiny blood vessels of patients with advanced heart failure or cardiogenic shock in the ICU. About 30 adults will have their oxygen measurements taken with the device and com…

This study watches brain oxygen levels in 30 adults on a heart-lung machine (VA-ECMO) for severe heart failure. Researchers check how blood flow from the machine relates to brain oxygen, heart function, and other vital signs. The goal is to learn how to better manage these critic…

This study will track 320 people in Hong Kong who have a heart attack complicated by cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will collect data on standard treatments, including the use of a heart pump called Impella, to…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This study looks at 100 adults who needed a breathing machine after a heart attack or cardiac arrest. Researchers want to see how often acid-base problems happen and compare the settings doctors used with those suggested by a computer algorithm. The goal is to improve future care…

This study looks back at medical records of 800 adults who had cardiogenic shock—a life-threatening condition where the heart suddenly can't pump enough blood. Researchers want to see if changes in treatment over the years have helped more people survive. Participants get standar…

This study looks at whether a standard way to measure pressure in the heart's left chamber (using a balloon-tipped catheter) gives the same results as the most accurate method (directly measuring pressure in the left atrium). The researchers will study 136 adults having heart sur…

This study tests a new device that measures a substance called nucleosomes in the blood right at the patient's bedside. Researchers want to see if these levels can help predict which critically ill patients are at higher risk of dying within 30 days. The study will include 130 ad…