CARDIOGENIC SHOCK

This study tests the Cardiohelp device, a heart-lung machine, in 50 children with severe heart failure to see if it is safe and works well for up to 30 days. It also compares two blood thinners (heparin vs. bivalirudin) to find which causes fewer bleeding or clotting problems. Th…

This study tests whether using less of the drug noradrenaline, by aiming for a lower blood pressure target (55 mmHg instead of 65 mmHg), can improve survival and reduce severe kidney failure in people with cardiogenic shock after a heart attack. About 776 adults will be randomly …

This study tests whether using a special heart monitor (pulmonary artery catheter) early in people with cardiogenic shock from heart failure can lower the risk of dying in the hospital. About 400 adults aged 18-90 with severe heart failure and shock will be enrolled. The monitor …

This study tests a new temporary heart pump (Magenta Elevate) in 10 people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. The pump is inserted through a blood vessel to help the left ventricle work. The goal is to see if it is safe a…

This study looks at whether setting a personalized blood pressure goal based on vein pressure can help people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. About 406 adults will be randomly assigned to either standard care or a tail…

This study tests whether a special heart monitor can help prevent serious problems like death, need for a heart pump, or repeat hospital stays in people who have survived a severe heart condition called cardiogenic shock. About 40 adults will be randomly assigned to get the monit…

This study tests whether starting a heart-lung machine (ECMO) right at the scene of a cardiac arrest, instead of waiting until the hospital, can improve survival and brain function. About 90 adults under 70 with witnessed cardiac arrest and bystander CPR will be enrolled. The goa…

This study tests whether using a heart-lung machine (ECMO) before a complex heart valve replacement can prevent death, cardiac arrest, or emergency surgery in high-risk patients. It includes 30 adults with severe aortic stenosis who are unstable or have tricky heart anatomy. Rese…

This study looks at whether adding a special balloon pump (IABP) to standard ECMO support helps people with severe heart failure recover more quickly. About 430 adults in cardiogenic shock will be randomly assigned to get ECMO alone or ECMO plus the pump. The main goal is to see …

This study compares starting kidney dialysis early versus at the usual time for people in severe heart shock who are on a heart-lung machine (ECMO) and have kidney injury. The goal is to see if early dialysis reduces death or the need for long-term dialysis. About 408 adults will…

This study tests a temporary heart pump called iVAC 2L in 100 people with severe coronary artery disease who need high-risk angioplasty. The pump helps the heart keep pumping blood during the procedure. Researchers will track deaths, heart attacks, and strokes for one year to see…

This study looks at 600 adults hospitalized with acute heart failure or cardiogenic shock. Researchers want to see if information from normal hospital care, plus blood and urine samples, can help predict who is at higher risk of dying within 30 days. No experimental treatments ar…

This study follows 350 people who survived cardiogenic shock (a severe heart condition) after leaving the hospital. Researchers want to see how many survive or need to be readmitted over time. The goal is to learn what happens after discharge and build better support for recovery…

This study is not testing a new drug or device. Instead, it will track 500 people with cardiogenic shock (a life-threatening condition where the heart suddenly can't pump enough blood) at four specialized hospitals. Researchers will collect detailed information on treatments and …

This study is observing 1,000 people hospitalized with acute heart failure to learn how to better predict their outcomes. Researchers will analyze blood markers, imaging, and other health data to identify patterns. The goal is to improve future care, not to test a new treatment.

This study looks at how a person's genes influence their immune response and recovery from cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect blood samples from 300 patients to identify genetic patterns linke…

This study looks back at medical records of 3,000 people who had cardiogenic shock—a life-threatening condition where the heart suddenly can't pump enough blood. Researchers want to see if survival rates improved after a special shock team started working at the hospital in 2017.…

This study is for people in cardiogenic shock who need a temporary heart pump called an intra-aortic balloon pump (IABC). Researchers want to see if the stiffness of a person's arteries affects how well the pump works. They will measure heart function before and after the pump is…

This study is a large registry that collects data on how a blood-filtering device called CytoSorb is used in real-world intensive care settings. It will include up to 3,000 critically ill patients with conditions like septic shock, severe lung injury, or liver failure. The goal i…