CARDIOGENIC SHOCK

This study tests whether a personalized blood transfusion approach, based on oxygen levels, is better than the standard method for people on a heart-lung machine (ECMO) due to severe heart failure. About 236 adults will be randomly assigned to one of two strategies to see which r…

This study tests a minimally invasive procedure to repair a leaky heart valve in people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. About 144 adults in intensive care will be randomly assigned to either standard medical therapy or…

This study tests whether adding a balloon pump (IABP) to standard ECMO support helps the heart recover better in people with severe cardiogenic shock. About 104 adults will be randomly assigned to get ECMO alone or ECMO plus the balloon pump. Researchers will measure heart functi…

This study tests whether replacing a narrowed heart valve right away (within 12 hours) helps people with severe aortic stenosis who are in cardiogenic shock, compared to the usual approach of stabilizing them in the ICU first. Thirty participants will be randomly assigned to one …

Cardiogenic shock is a life-threatening condition where the heart can't pump enough blood. This study tests whether setting a personalized blood pressure target based on central venous pressure improves survival and reduces organ damage compared to the standard fixed target. Abou…

This study tests whether using less of the drug noradrenaline, by aiming for a lower blood pressure target (55 mmHg instead of 65 mmHg), can improve survival and reduce severe kidney failure in people with cardiogenic shock after a heart attack. About 776 adults will be randomly …

This study looks at whether placing a special balloon pump (IABP) early after starting ECMO can improve survival in adults with cardiogenic shock—a life-threatening condition where the heart can't pump enough blood. About 358 participants will be randomly assigned to get the ball…

This pilot study tests whether an implanted heart pressure monitor (CardioMEMS) can help prevent complications in 40 patients who survived cardiogenic shock. Participants will have the device implanted and receive regular pressure checks and medication adjustments. The goal is to…

This early study is testing a new heart pump device (Magenta Elevate) in 10 people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. The device is inserted through a blood vessel to help the heart pump. Researchers are checking if it is…

This study tests whether giving a special life-support machine (ECMO) at the scene of a cardiac arrest helps more people survive than waiting until they reach the hospital. About 90 adults under 70 who have a witnessed heart attack and receive bystander CPR will be included. The …

This study tests a compact heart-lung machine called Cardiohelp in 50 children with severe heart failure. The device supports the heart for up to 30 days while kids recover or await a transplant. The trial also compares two blood thinners to see which causes fewer bleeding or clo…

This study is for adults with severe cardiogenic shock who need a heart-lung machine (ECMO) and have developed acute kidney injury. Researchers want to see if starting dialysis (continuous renal replacement therapy) earlier improves survival and reduces long-term kidney dependenc…

This study tests whether using a heart-lung machine (ECMO) before a high-risk aortic valve replacement can prevent death, cardiac arrest, or emergency surgery. It includes 30 adults with severe aortic stenosis who are unstable or have complex anatomy. Participants receive ECMO su…

This study tests whether adding an intra-aortic balloon pump (IABP) to standard ECMO support helps more people with severe cardiogenic shock recover enough to come off the heart-lung machine. About 430 adults will be randomly assigned to get ECMO alone or ECMO plus IABP. The main…

This study tests whether using a special heart monitor (pulmonary artery catheter) early in the hospital can lower the risk of death for people in cardiogenic shock caused by heart failure. About 400 adults with severe heart failure and shock will be randomly assigned to get eith…

This study tests a temporary heart pump called iVAC 2L in 100 patients undergoing high-risk angioplasty. The pump helps stabilize blood flow during the procedure. Researchers will track deaths, heart attacks, strokes, and other complications for up to a year to see if the device …

This study looks at whether giving a special ketone drink through a feeding tube is safe and practical for people with severe heart failure. The goal is to see if it can help the heart use energy better. The study involves 12 participants with very weak hearts who are in the hosp…

This study gathers detailed, real-time information from the Impella heart pump and standard hospital monitors in 125 people with cardiogenic shock. The goal is to better understand how the pump and the body's vital signs work together. No new treatment is being tested; instead, r…

This registry will collect health information from 8,000 patients with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will track what treatments patients receive and how they fare, including survival rates in the hosp…

This observational study follows 800 adults admitted to a cardiology department with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will review medical records from 2017 onward to see how treatments and survival rates…

This study looks at data from 100 adults with cardiogenic shock who received an Impella 5.5 heart pump. Researchers aim to build a tool that uses pump signals to predict whether a patient's own heart will recover. The goal is to improve decision-making and reduce complications li…

This study is a registry that will follow 3000 people hospitalized with cardiogenic shock, a life-threatening condition where the heart suddenly cannot pump enough blood. Researchers will collect information on how patients are treated and what happens to them over time. The goal…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life-support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals, then work with patients, families, and staff to design a safer sedat…

This study watches 600 adults on a heart-lung machine (ECMO) for severe shock to see how often they develop heart rhythm problems like atrial fibrillation. It tracks complications and recovery times. The goal is to learn more, not to test a new treatment.

This study looks at 26 people with severe heart failure who are in cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will measure specific markers in the blood related to inflammation and blood vessel health. The goal is to bette…

This observational study will follow 600 adults hospitalized with acute heart failure or cardiogenic shock. Researchers will collect information from routine care, plus extra blood and urine samples, to see if they can better identify different types of shock and predict who is a…

This study is observing 1,000 people hospitalized with acute heart failure to learn how to better predict their outcomes. Researchers will use blood tests, imaging, and other measurements to identify different patient types. The goal is to improve future treatment and care for th…

This study follows 500 people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect data from four specialized centers to understand what treatments work best and why some patients do better than others. No…

This study looks at whether having a dedicated cardiogenic shock team helps more people survive severe heart failure or heart attack. Researchers will compare survival rates before and after the team was created, using data from up to 3,000 patients. The goal is to see if this te…

This observational pilot study at Thomas Jefferson University will enroll 20 adults with cardiogenic shock who are already receiving an intra-aortic balloon pump (IABC). Researchers will measure baseline arterial compliance (how stiff the arteries are) and then track heart functi…

This registry follows 350 people who survived cardiogenic shock (a severe form of heart failure) after they leave the hospital. Researchers want to learn about deaths, hospital readmissions, and other challenges patients face in the months and years after discharge. The goal is t…

This study looks at how genes affect the immune system and treatment responses in people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect blood samples from 300 patients to identify genetic patterns li…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …