CARDIOGENIC SHOCK

This trial tests the drug istaroxime in 600 adults with mild to moderate cardiogenic shock caused by acute heart failure. Participants receive a 48-hour IV infusion of istaroxime or a placebo, plus standard care. Researchers measure changes in blood pressure, breathing, and overa…

This study tests a new device called SynFlow Duro, a temporary heart pump for people who go into severe shock after heart surgery. About 60 adults in China will receive the pump to see if it helps their heart recover or keeps them stable until a transplant or permanent device. Th…

This study will compare norepinephrine and dopamine as the first drug given to adults with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. About 512 participants will be randomly assigned to one of the two drugs. The goal is to see which d…

This study tests whether using a heart pump (Impella 5.5) along with standard heart failure medications can help people with severe heart failure and shock recover without needing a heart transplant or permanent artificial heart. About 250 adults with weak hearts (ejection fracti…

This study tests whether routinely placing a small tube in the leg artery (distal perfusion catheter) is better than waiting until a problem arises in patients on mechanical heart pumps. About 500 adults with severe heart failure or shock will be randomly assigned to one of the t…

This early-phase trial tests a new treatment for people in shock after a severe heart attack. The therapy uses specially engineered immune cells (CAR-DC) to target a protein found in heart scar tissue, aiming to calm the immune response. The study will enroll 18 patients and prim…

This study tests if giving a short course of steroids (methylprednisolone) for 7 days can help adults with heart failure who are in cardiogenic shock, a serious condition where the heart can't pump enough blood. The goal is to reduce harmful inflammation and help patients recover…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study tests a new, non-invasive device called ODIN that measures how well oxygen is being used in the tiny blood vessels of patients with advanced heart failure or cardiogenic shock in the ICU. About 30 adults will have their oxygen measurements taken with the device and com…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This study looks at 30 adults on a heart-lung machine (ECMO) for severe heart failure. Researchers will measure brain oxygen levels and compare them to blood flow and other vital signs. The goal is to see if brain oxygen monitoring can help guide treatment and improve survival in…

This study looks at 100 adults who needed a breathing machine after a heart attack or cardiac arrest. Researchers want to see how often acid-base problems happen and compare the settings doctors used with those suggested by a computer algorithm. The goal is to improve future care…

This study will collect information from 1,200 patients in the French West Indies and Guiana who received ECMO, a machine that helps the heart and lungs. Researchers aim to track survival rates and complications to better understand how ECMO works in this region. The study does n…

This study will track 320 people in Hong Kong who have a heart attack complicated by cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will collect data on standard treatments, including the use of a heart pump called Impella, to…

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…

This study will compare two ways of measuring pressure inside the heart during heart surgery: the gold standard (direct left atrial pressure) and a more common indirect method (pulmonary capillary wedge pressure). Researchers want to see if the indirect method is accurate enough …