CARDIOGENIC SHOCK

This study tests whether a heart pump (Impella 5.5) combined with optimized heart failure medications can help people with severe heart failure and shock recover without needing a transplant or permanent heart assist device. About 250 adults aged 18-79 with a weak heart pump (LVE…

This early-phase trial tests a new treatment made from specially engineered immune cells (CAR-DC) for people who have had a severe heart attack and are in shock. The treatment targets a protein called FAP to calm harmful inflammation. The study will enroll 18 adults and primarily…

This study looks at 500 adults with severe heart failure or shock who need a heart pump placed through the leg artery. It compares placing a small leg catheter routinely versus only when needed, to see which approach better prevents serious leg complications. The goal is to find …

This study tests whether a 7-day course of intravenous steroids can reduce harmful inflammation and help 30 adults recover from heart failure-related cardiogenic shock. Participants must have high inflammation levels and be in the ICU. The goal is to see if the treatment is safe …

This study looks at whether a new rapid blood test, done right at the patient's bedside, can help predict which critically ill patients are at higher risk of dying within 30 days. The test measures a substance called nucleosomes in the blood. Researchers will compare this quick t…

This study looks at 100 adults who needed a breathing machine after a heart attack or cardiac arrest. Researchers want to see how often acid-base problems happen and whether a computer program could suggest better ventilator settings. No new treatments are given—the team will rev…

This study looks at whether a widely used heart pressure measurement (PCWP) accurately reflects the true pressure inside the heart's left chamber (LAP) during heart surgery. Researchers will compare these two measurements in 136 adults undergoing elective heart surgery with a hea…

This study will collect information from 1,200 patients in the French West Indies and Guiana who receive ECMO, a machine that helps the heart and lungs work. The goal is to learn how well ECMO works and what problems may occur. No new treatments are being tested; instead, researc…

This study is a registry that will collect information from about 320 people in Hong Kong who have had a severe heart attack complicated by cardiogenic shock, a condition where the heart cannot pump enough blood. The goal is to track outcomes for patients who receive a mechanical…