Substance-related disorder

This trial tests whether a weekly IV antibiotic called oritavancin, given alongside medication for opioid use disorder, can help people finish treatment for serious infections like bloodstream or bone infections without needing to stay in a nursing facility. The study enrolls adu…

This phase 2 study tested a drug called TMP-301 in 110 adults with alcohol use disorder to see if it is safe and helps reduce drinking. Participants took TMP-301 or a placebo daily for 14 weeks. The trial was terminated early, so we don't have clear results on whether the drug wo…

This study tested a mobile app that uses rewards to encourage people with opioid use disorder to start and stick with medication-assisted treatment after an emergency room visit. 41 adults from two hospitals were given access to the app for 12 weeks. The goal was to see if the ap…

This study tested a special program called ADAPT for families who adopted children from foster care. The program includes sessions on trust, behavior management, and dealing with loss. Researchers wanted to see if it could improve children's mental health and prevent family disru…

This study tested a program to help HIV-negative transgender women and men who have sex with men who also have a substance use disorder stick with PrEP, a daily pill or shot that prevents HIV. Participants received counseling and text support, with extra help for those who strugg…

Researchers are testing whether a 12-week exercise program can improve thinking skills, physical fitness, and quality of life for adults in opioid substitution therapy. Participants are randomly assigned to start exercise right away or after a 12-week wait. The study measures cha…

Transgender and gender diverse adults smoke at higher rates than the general population, and stigma, discrimination, anxiety, and depression may make quitting harder. Researchers at Massachusetts General Hospital are adapting an existing smoking cessation program called QUIT, whi…

This early study tested a new drug called TRV734 in 5 adults with opioid-use disorder who were already on methadone. The goal was to see if TRV734 could relieve withdrawal symptoms with fewer side effects than a standard opioid like oxycodone. Participants stayed in a residential…

This study tested whether psilocybin, the active ingredient in magic mushrooms, is safe and feasible for people with methamphetamine use disorder. Only 5 participants were enrolled, and the trial was terminated early, so the results are very limited. The goal was to see if psiloc…

This study tested a new method for starting buprenorphine (a medication for opioid use disorder) in hospitalized adults who also have chronic pain. Instead of requiring patients to stop all other opioids and go through withdrawal first, the new method starts with very low doses o…

This study tested a mindfulness-based mobile app designed specifically for young Black men (ages 18-29) to help them handle stress from racism and reduce alcohol or marijuana use. Participants used a self-guided app, some with real-time feedback, and reported their daily stress a…

This study looks at how men and women with cannabis use disorder react differently to THC, the main psychoactive ingredient in cannabis. Researchers will give 40 adults either a THC pill or a placebo and use brain scans to measure changes in reward-related brain activity. The goa…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study tested whether a mobile app (eIntervention) could help adults with moderate to high-risk drug or alcohol use reduce their substance use and get into treatment. Participants were primary care patients who screened positive for substance use. The app was added to standar…