Subjective cognitive decline

This study investigates whether intensively lowering systolic blood pressure with FDA-approved medications can reduce the buildup of amyloid and tau proteins in the brain—hallmarks of Alzheimer's disease. The trial enrolls adults aged 60-85 with high blood pressure who are cognit…

This study tests whether smartphone usage data can help tell the difference between normal memory complaints, mild cognitive decline, and Alzheimer's disease. Researchers will collect data from 90 participants' phones over three months. If it works, it could offer a simple, low-c…

This study is looking for better ways to diagnose Parkinson's disease using samples that are easy to collect, like blood, skin, and nasal swabs. Researchers will compare these samples from 340 people, including those with Parkinson's, Alzheimer's, and healthy volunteers. The goal…

This study tests whether combining aerobic exercise with cognitive training, delivered via interactive 'exergames' at home, can help prevent Alzheimer's in older adults who have memory concerns but no diagnosed dementia. Participants will be randomly assigned to either an exergam…

This study tests an 8-week group program called My Healthy Brain for adults aged 50 and older who have memory concerns but not dementia. The program teaches about lifestyle factors like exercise, sleep, and diet that may help prevent dementia. Researchers want to see if the progr…

This study tests whether a combination of aerobic exercise, cognitive training, and turmeric (with black pepper) can prevent memory decline in adults aged 55-70 who have insulin resistance and self-reported memory concerns. Participants will follow a 24-week program, repeated aft…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory in older adults with mild cognitive impairment or subjective memory complaints. About 70 participants will be randomly assigned to receive either …

This study tests a rideshare service where drivers are specially trained to assist older adults, including those with Alzheimer's or memory problems. The drivers help riders from door to door, even handing them off to clinic staff. The goal is to see if this service reduces misse…

This study tests whether trained older adult peer coaches can help people aged 60+ who have both depressive symptoms and subjective cognitive decline (memory concerns). Participants take part in 8 weekly video chats focused on emotional and practical support. The goal is to see i…

This study tests a tablet-based app called the Digital Memory Notebook (DMN) to help older adults with mild memory problems or early Alzheimer's manage everyday tasks like appointments and medications. Twenty participants will learn to use the app over six weekly sessions, then c…

This study tests if learning memory techniques (like mnemonics) can improve thinking and memory in adults over 50 who have mild memory concerns. 80 participants will either take memory training or just get information. The goal is to see if training helps and if benefits last up …

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can improve memory and mood in adults aged 60-80 who have subjective cognitive decline (worries about memory) and depression. Eighty-six participants will receive either real or sham e…

This study tests whether a probiotic called PS23 can improve thinking and quality of life in people aged 50-85 who feel their memory is slipping but don't have dementia. Forty participants will take one capsule daily for 12 weeks, and researchers will measure changes in computer-…

This study tests if shining a special near-infrared light on the head and through the nose can improve memory and brain function in older adults at risk for Alzheimer's disease. The treatment, called photobiomodulation, is low-risk and aims to boost brain cell energy. 168 partici…

This study tests whether teaching memory strategies and promoting exercise, mental activities, and stress management can help older adults with memory concerns keep their thinking sharp. About 263 people aged 65 and older with normal cognition but subjective memory worries will j…

This study looks at whether giving older adults (ages 60-79) personalized advice and extra support helps them follow brain-healthy habits like a Mediterranean diet, exercise, and staying socially active. Participants have mild memory concerns or are at risk for cognitive decline.…

This study looks at whether adults aged 65 and older with memory concerns can collect a small blood sample at home to check for Alzheimer's disease risk. Participants will use a simple device to draw blood, mail it to a lab, and get results from a doctor over video. The goal is t…

This study looks at whether people with memory problems will wear and use digital devices like smartwatches, sleep headbands, and smartphone apps to collect health data. Researchers will combine this data with clinical information to build machine learning models that might one d…

This study tests a 4-month program that combines memory strategies with fun leisure activities like music or Spanish lessons, plus brain games. It involves 144 adults who feel their memory is getting worse but still test in the normal range. The goal is to see if this approach ca…

This study uses MRI scans to track how blood vessels in the brain change over time in people with early Alzheimer's disease and healthy volunteers. Researchers aim to understand if reduced blood vessel reactivity is an early sign of dementia. The study involves 120 participants a…