Subjective cognitive decline

This study follows 121 people who carry the APOE-ε4 gene variant and have noticed subtle memory slips—a group at higher risk for Alzheimer's. They previously completed a 12-month program combining diet, exercise, cognitive training, and a green tea extract (EGCG). Now, researcher…

This study tests a brain health service designed to assess and reduce dementia risk in people aged 55 to 85 who have subjective cognitive decline (memory concerns without objective impairment). Participants are randomly assigned to either a personalized 6-month program—combining …

This pilot study tests whether a personalized lifestyle program combining workshops, remote coaching, and a smartphone app can help adults aged 55-75 at risk for dementia adopt healthier habits. 300 participants will either receive tailored guidance or standard advice. The main g…

This trial tests whether a daily conversation platform powered by artificial intelligence can support cognitive health in older adults at high risk of dementia. Participants engage in voice-based conversations tailored to their interests, designed to exercise memory, attention, l…

This pilot study explores whether a personalized telerehabilitation program can help adults who notice cognitive slips in daily life. Participants include older adults and adults with Ehlers-Danlos Syndrome who report subjective cognitive complaints. Over six weeks, they receive …

This study tests whether a handheld robot that guides meditation with touch and voice can improve sleep quality in older adults with mild memory concerns. 100 participants will either use the robot or a standard meditation app for daily sessions. The goal is to see if the robot h…

This study will test whether using a virtual reality (VR) headset for cognitive and physical exercises is practical and well-liked by people with mild cognitive impairment. Ten participants will do three supervised VR sessions per week for six weeks. The goal is to see if they ca…

This pilot study tests whether simple bedroom changes and sleep tips can improve sleep for older adults (65+) who live alone, have memory concerns, and struggle with insomnia. Over 8 weeks, researchers will visit participants' homes to adjust the bedroom environment and provide s…

This study tests whether an artificial intelligence (AI)-guided sleep program is practical and well-liked by adults aged 60 and older who have both insomnia and mild memory concerns. Researchers will enroll 60 participants to check how many people join, stick with the program, an…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce a group of common symptoms—pain, tiredness, sleep problems, anxiety, depression, and memory fogginess—in breast cancer survivors who are on hormone therapy. About 228 women …

This study tests whether a 6-month program of reciting Chinese classics can improve memory in people aged 60+ who feel their memory is slipping. Sixty participants will be split into two groups: one does the recitation training, the other does not. Researchers will use brain scan…

This study tests whether shining red and near-infrared light on the forehead, inside the nose, and on the neck can improve memory and mood in older adults who feel their thinking is slipping. Eighty participants will use a light device at home twice daily for five weeks. Research…

This study tests a gentle, non-invasive brain stimulation technique called so-tDCS in 80 older adults who have mild memory and sleep complaints. Participants will receive either real or sham stimulation over 4 weeks. Researchers will track changes in memory, sleep quality, and br…

This study tests two different supervised exercise programs in 350 adults aged 60 and older in Angola. One program includes strength, balance, and coordination exercises, while the other focuses on basic strengthening and daily activities. Both are done three times a week for 12 …

The AHEAD study is testing whether artificial intelligence can help detect early signs of Alzheimer's disease in people who feel their memory is slipping but still test normal. Researchers will use brain scans, eye tests, and blood markers to identify those at highest risk. High-…

This study will test an Italian version of a questionnaire called the dynamic Neurocognitive Adaptation (dNA) scale in 265 older adults, including those with normal aging, mild memory complaints, or dementia. The goal is to see if higher scores on the scale—reflecting more engage…

This study tests a group program for older adults living in the community who feel their memory is slipping. The program includes social activities, brain games, physical exercise, healthy eating advice, and emotional support. Researchers will measure memory, thinking, and mood o…

This study will follow 1,000 older adults from under-resourced communities who have early memory concerns or mild cognitive impairment. Participants will be monitored through phone or video visits, with data collected on thinking skills, brain scans, and blood samples. The goal i…