Peripheral nervous system disorder
MONDO:0003620A disease involving the peripheral nervous system.
Also known as: PNS (peripheral nervous system) diseases, PNS disease, PNS diseases, disease of peripheral nervous system, disease or disorder of peripheral nervous system, disorder of peripheral nervous system, disorder of the peripheral nervous system, peripheral nervous system disease
2293 clinical trials for this condition and its sub-types, 121 tagged with Peripheral nervous system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Peripheral nervous system disorder
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Peripheral neuropathy 93 trials · 1,473 incl. sub-types
30 sub-types
- Hereditary peripheral neuropathy 6 trials · 479 incl. sub-types Sub-types →
- Neuralgia 238 trials · 384 incl. sub-types Sub-types →
- Nerve compression syndrome 24 trials · 207 incl. sub-types Sub-types →
- Diabetic neuropathy 182 trials · 193 incl. sub-types Sub-types →
- Chemotherapy-induced neuropathy 171 trials
- Polyneuropathy 32 trials · 133 incl. sub-types Sub-types →
- Mononeuropathy 4 trials · 112 incl. sub-types Sub-types →
- Acquired peripheral neuropathy 0 trials · 95 incl. sub-types Sub-types →
- Nerve plexus disorder 0 trials · 75 incl. sub-types Sub-types →
- Sensory peripheral neuropathy 4 trials · 58 incl. sub-types Sub-types →
- Traumatic neuropathy 55 trials
- Neuritis 18 trials · 29 incl. sub-types Sub-types →
- Peripheral nerve lesion 1 trial · 12 incl. sub-types Sub-types →
- Autonomic neuropathy 7 trials · 10 incl. sub-types Sub-types →
- Chronic idiopathic neuropathy 5 trials
- Axonal neuropathy 1 trial · 4 incl. sub-types Sub-types →
- Neuropathy, small fiber 4 trials
- Infectious neuropathy 2 trials
- Vasculitic neuropathy 2 trials
- Autoimmune neuropathy 1 trial
- Idiopathic small fibers neuropathy 1 trial
- Ischemic neuropathy 1 trial
- Motor peripheral neuropathy 0 trials · 1 incl. sub-types Sub-types →
- Radiation-induced neuropathy 0 trials · 1 incl. sub-types Sub-types →
- Sarcoid neuropathy 1 trial
- Neuropathy in cryoglobulinemia 0 trials
- Neuropathy in endocrine disorder 0 trials
- Paraproteinemia-associated neuropathy 0 trials
- Uremic neuropathy 0 trials
- Vitamin deficiency related neuropathy 0 trials
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Autonomic nervous system disorder 59 trials · 209 incl. sub-types
13 sub-types
- Dysautonomia 16 trials · 64 incl. sub-types Sub-types →
- Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Sympathetic nervous system disorder 8 trials · 28 incl. sub-types Sub-types →
- Pure autonomic failure 18 trials
- Autonomic dysreflexia 11 trials
- Autonomic neuropathy 7 trials · 10 incl. sub-types Sub-types →
- Central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease 5 trials
- Baroreflex failure 1 trial
- Frey syndrome 0 trials
- Chronic hiccup 0 trials
- Harlequin syndrome 0 trials
- Idiopathic peripheral autonomic neuropathy 0 trials
- Parasympathetic nervous system disorder 0 trials Sub-types →
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Peripheral nervous system neoplasm 3 trials · 197 incl. sub-types
9 sub-types
- Nerve sheath neoplasm 8 trials · 123 incl. sub-types Sub-types →
- Peripheral nervous system cancer 0 trials · 67 incl. sub-types Sub-types →
- Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Cranial nerve neoplasm 0 trials · 8 incl. sub-types Sub-types →
- Benign neoplasm of peripheral nervous system 0 trials Sub-types →
- Mediastinal neural neoplasm 0 trials Sub-types →
- Nerve plexus neoplasm 0 trials Sub-types →
- Nerve root neoplasm 0 trials Sub-types →
- Peripheral ganglioneuroblastoma 0 trials Sub-types →
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Autoimmune disorder of peripheral nervous system 0 trials · 195 incl. sub-types
4 sub-types
- Myasthenia gravis 159 trials · 160 incl. sub-types Sub-types →
- Guillain-Barre syndrome 23 trials · 39 incl. sub-types Sub-types →
- Autoimmune neuropathy 1 trial
- Autoimmune optic neuritis 0 trials
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Radiculopathy 163 trials
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Third cranial nerve disorder 1 trial · 87 incl. sub-types
2 sub-types
- Oculomotor nerve paralysis 1 trial · 87 incl. sub-types Sub-types →
- Oculomotor nerve neoplasm 0 trials Sub-types →
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Trigeminal nerve disorder 3 trials · 63 incl. sub-types
4 sub-types
- Trigeminal neuralgia 37 trials
- Trigeminal autonomic cephalalgia 8 trials · 27 incl. sub-types Sub-types →
- Ophthalmic herpes zoster 0 trials
- Trigeminal nerve neoplasm 0 trials Sub-types →
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Facial nerve disorder 4 trials · 53 incl. sub-types
9 sub-types
- Bell's palsy 29 trials Sub-types →
- Facial neuralgia 16 trials
- Clonic hemifacial spasm 4 trials
- Facial hemiatrophy 3 trials
- Mobius syndrome 2 trials Sub-types →
- Melkersson-Rosenthal syndrome 0 trials
- Facial nerve neoplasm 0 trials
- Geniculate ganglionitis 0 trials
- Isolated facial myokymia 0 trials
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Neuroma 20 trials · 27 incl. sub-types
2 sub-types
- Morton neuroma 7 trials
- Multiple mucosal neuroma 0 trials
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Olfactory nerve disorder 8 trials · 12 incl. sub-types
1 sub-type
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
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Vestibulocochlear nerve disorder 2 trials · 11 incl. sub-types
2 sub-types
- Vestibular neuronitis 9 trials
- Vestibulocochlear nerve neoplasm 0 trials Sub-types →
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Glossopharyngeal nerve disorder 2 trials · 8 incl. sub-types
5 sub-types
- Vagus nerve disorder 4 trials Sub-types →
- Glossopharyngeal neuralgia 2 trials
- Glossopharyngeal motor neuropathy 0 trials
- Glossopharyngeal nerve neoplasm 0 trials Sub-types →
- Glossopharyngeal nerve paralysis 0 trials
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Cauda equina syndrome 2 trials
1 sub-type
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Abducens nerve disorder 0 trials · 2 incl. sub-types
2 sub-types
- Abducens nerve palsy 2 trials
- Abducens nerve neoplasm 0 trials
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Accessory nerve disorder 1 trial
1 sub-type
- Spinal accessory nerve neoplasm 0 trials
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Hypoglossal nerve disorder 1 trial
1 sub-type
- Hypoglossal nerve neoplasm 0 trials Sub-types →
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Trochlear nerve disorder 1 trial
2 sub-types
- Fourth cranial nerve palsy 1 trial Sub-types →
- Trochlear nerve neoplasm 0 trials
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Peroneal nerve paralysis 0 trials
Most studied deeper sub-types
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New combo therapy targets nerve pain in rare blood cancers
Disease control OngoingThis study tests whether combining acalabrutinib with rituximab is safe and effective for people with nerve damage (neuropathy) linked to two blood conditions: IgM MGUS or Waldenstrom macroglobulinemia. The main goal is to see if the treatment lowers a key protein (IgM) in the bl…
Phase 2 • Sponsor: Shayna Sarosiek, MD • Aim: Disease control
Last updated Jun 27, 2026 08:02 UTC
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Promising nerve pain drug trial for MGUS patients withdrawn before start
Disease control CancelledThis study aimed to test if daratumumab could improve nerve damage (peripheral neuropathy) in people with a blood condition called MGUS. Participants would have received weekly injections for two months, then biweekly for four more months. However, the trial was withdrawn before …
Phase 2 • Sponsor: Georgetown University • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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New screening tool aims to catch diabetic nerve damage early
Diagnosis OngoingThis study tests a short questionnaire called ACT to see if it can accurately detect nerve damage in the feet and legs of people with diabetes. Researchers will compare it to standard screening tools and an eye test that looks at tiny nerve fibers. The goal is to find a simple, n…
Sponsor: Weill Cornell Medical College in Qatar • Aim: Diagnosis
Last updated Jun 26, 2026 14:24 UTC
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Wearable insoles warn of foot pressure to stop diabetic ulcers
Prevention OngoingThis trial tests a wearable insole system that monitors foot pressure, temperature, and movement, giving real-time alerts to help users shift weight and avoid injury. The study includes people with type 1 or 2 diabetes who have nerve damage and a recent history of healed foot ulc…
Sponsor: Johns Hopkins University • Aim: Prevention
Last updated Jul 16, 2026 00:00 UTC
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Cold hands, healthy nerves? study tests cryotherapy to block chemo side effect
Prevention PausedThis study tests whether wearing cold gloves during chemotherapy can prevent peripheral neuropathy (nerve damage causing numbness, tingling, or pain) in colon cancer patients. Forty adults with stage III colon cancer who are about to start a common chemo regimen (CAPOX) will be r…
Sponsor: NYU Langone Health • Aim: Prevention
Last updated Jun 27, 2026 09:10 UTC
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Massage may ease chemo nerve damage
Symptom relief OngoingThis study looks at whether massage therapy can reduce nerve problems like pain, numbness, and tingling caused by chemotherapy in people with breast or digestive system cancers. About 90 participants will receive massage sessions to see if it improves symptoms and quality of life…
Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Sep 20, 2026 00:00 UTC
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New shot aims to quiet chemo nerve pain
Symptom relief OngoingThis study tests an injected drug called Halneuron to see if it can safely reduce nerve pain caused by chemotherapy. About 240 adults who have nerve pain from platinum or taxane chemo will receive either Halneuron or a placebo shot. The goal is to measure pain relief, sleep, fati…
Phase 2 • Sponsor: Dogwood Therapeutics Inc. • Aim: Symptom relief
Last updated Sep 18, 2026 00:00 UTC
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Vitamin B3 derivative may soothe Chemotherapy's lingering nerve damage
Symptom relief OngoingThis phase 2 trial tests whether nicotinamide riboside (NIAGEN), a form of vitamin B3, can reduce persistent nerve pain and numbness in cancer survivors who completed chemotherapy with taxane or platinum drugs 1 to 12 months earlier. Participants take either NIAGEN or a placebo d…
Phase 2 • Sponsor: Donna Hammond, PhD • Aim: Symptom relief
Last updated Aug 22, 2026 00:00 UTC
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Brain training offers new hope for chemo nerve pain
Symptom relief OngoingThis study tests whether a non-invasive therapy called neurofeedback can help people with chemotherapy-induced nerve pain learn to change their own brain waves to feel less pain. About 80 participants will be assigned to either receive neurofeedback training or a control conditio…
Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Aug 13, 2026 00:00 UTC
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Needles vs. nerve pain: can acupuncture shield breast cancer patients from chemotherapy side effects?
Symptom relief OngoingThis trial tests whether acupuncture can prevent taxane-induced peripheral neuropathy (TIPN) — nerve damage causing pain and tingling in arms and legs — from worsening in breast cancer patients receiving weekly taxane chemotherapy. Participants with early-stage breast cancer who …
Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Symptom relief
Last updated Aug 07, 2026 00:00 UTC
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Exercise and diet may ease nerve damage and fatigue during chemo
Symptom relief OngoingThis study tests whether a tailored exercise program and nutritional guidance can reduce peripheral neuropathy (nerve damage) and fatigue in people with colorectal cancer receiving chemotherapy. Participants follow a supervised exercise routine and monthly nutrition check-ins dur…
Sponsor: St. Olavs Hospital • Aim: Symptom relief
Last updated Jul 22, 2026 00:00 UTC
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Scrambler therapy offers hope for young cancer survivors with nerve pain
Symptom relief OngoingThis study looks at whether Scrambler therapy can safely reduce painful nerve damage caused by chemotherapy in adolescents and young adults (ages 15-39) who have finished active cancer treatment. Participants are randomly assigned to receive the therapy right away or after a wait…
Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jul 10, 2026 00:00 UTC
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Laser light shows promise for rare nerve pain
Symptom relief By invitation onlyThis study tests whether photobiomodulation (low-level laser therapy) can reduce pain and disability in people with anti-MAG neuropathy, a rare nerve condition. Ten participants will receive 16 laser sessions over six weeks. Researchers will measure changes in disability, pain, a…
Sponsor: Centre Hospitalier de Cornouaille • Aim: Symptom relief
Last updated Jun 27, 2026 14:01 UTC
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Exercise program aims to ease chemo nerve damage in cancer survivors
Symptom relief OngoingThis study tests whether a 10-week, at-home exercise program is safe and helpful for cancer survivors who have ongoing nerve pain, numbness, or tingling from chemotherapy. About 40 participants will do remote exercise sessions and health coaching calls. The goal is to see if the …
Phase 1 • Sponsor: University Health Network, Toronto • Aim: Symptom relief
Last updated Jun 27, 2026 13:02 UTC
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Nerve cap aims to ease pain after limb loss
Symptom relief OngoingThis study tests a special nerve cap (Axoguard Large-Diameter Nerve Cap) in 15 adults who have had a limb injury or amputation. The cap is placed over the cut nerve end to protect it and may help reduce chronic nerve pain. The goal is to see if the cap is safe and works well befo…
Sponsor: Axogen Corporation • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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New hope for chemo pain: nerve zap study launches
Symptom relief OngoingThis study tests a treatment called neuromodulation to see if it can reduce nerve pain caused by chemotherapy. About 24 adults with nerve pain in their legs from certain chemo drugs will take part. Researchers will check for side effects and measure changes in pain and nerve func…
Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:38 UTC
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Could a daily 5-Minute mask soothe nerve pain?
Symptom relief OngoingThis phase 2 trial tests a special hand and foot mask designed to ease nerve pain caused by chemotherapy or diabetes. Sixty adults will apply the mask daily for 5 minutes over one week. Researchers will measure changes in symptoms and quality of life using questionnaires.
Phase 2 • Sponsor: SHIANG-SUO HUANG • Aim: Symptom relief
Last updated Jun 27, 2026 12:32 UTC
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New nerve patch could ease pain after biopsy
Symptom relief OngoingThis study tests a biodegradable tube that is placed over a cut nerve during a leg biopsy. The goal is to see if it is safe and reduces common side effects like pain, redness, and swelling. Twenty adults with various nerve conditions are taking part, and half will get the tube wh…
Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Soundwave therapy shows promise for chemo nerve damage
Symptom relief OngoingThis study tests a device called SensoniQ® Treatment Station that uses low frequency soundwaves to prevent or reduce nerve pain caused by chemotherapy in people with gynecologic cancer. The trial includes 80 participants, some starting chemo and others with lasting nerve pain. Re…
Sponsor: Augusta University • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Micro-Implant zaps nerve pain: new hope for chronic sufferers?
Symptom relief OngoingThis study tests a small, implantable device that stimulates nerves to relieve chronic pain after injury or surgery. About 185 adults with peripheral neuralgia will either receive the stimulator plus standard medical care or standard care alone. The goal is to see if the device p…
Sponsor: Nalu Medical, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 09:11 UTC
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New pain relief for diabetic nerves? trial pulled before start
Symptom relief CancelledThis study was designed to test a new drug called N0750 against two standard pain medications (Cymbalta and Lyrica) for painful diabetic peripheral neuropathy. It planned to enroll adults with diabetes and nerve pain for at least 3 months. However, the trial was withdrawn before …
Phase 3 • Sponsor: Eurofarma Laboratorios S.A. • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Researchers track rare nerve disease to unlock future treatments
Knowledge-focused OngoingThis study follows 20 people with a rare nerve disease called CMT4J for up to 2 years. Researchers will track symptoms and health changes to better understand how the disease progresses. The goal is to find better ways to measure the disease, which could help design future treatm…
Sponsor: Elpida Therapeutics SPC • Aim: Knowledge-focused
Last updated Jul 10, 2026 00:00 UTC
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Can your genes predict chemo nerve pain?
Knowledge-focused OngoingThis study looks at how a person's genes and medical history might help predict nerve damage caused by chemotherapy. Researchers will follow 300 people with certain cancers who are scheduled for specific chemo drugs. The goal is to find patterns that could help prevent or reduce …
Sponsor: National Cheng-Kung University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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New study tracks nerve pain from breast cancer drug
Knowledge-focused OngoingThis study follows 36 people with HER2-positive breast cancer who are receiving the drug T-DM1. Researchers want to learn how often and how severely the drug causes nerve damage (peripheral neuropathy), such as numbness, tingling, or pain. Participants will report their symptoms …
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC